Matrix metalloproteinases and their impact on sinusal extension in chronic rhinosinusitis with nasal polyps

Malinsky, Rafael Rossell; Valera, Fabiana Cardoso Pereira; Cavallari, Fransérgio E. M.; Küpper, Daniel; Milaneze, Cristiane; Silva, João; Tamashiro, Edwin; Anselmo‐Lima, Wilma Terezinha

doi:10.1007/s00405-012-2219-9

Cited by 36 publications

(35 citation statements)

References 14 publications

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“…In a study on tissue samples of CRSwNP and controls, a significantly higher messenger RNA (mRNA) gene expression of MMP-1, MMP-2, and MMP-9 was observed in the CRSwNP group when compared to controls. No significant correlation has been observed between MMP gene expression and sinonasal computed tomography (CT) scan extension [33]. This confirmed a previous report in which MMP-2 and MMP-9 expression intensity was not correlated with the endoscopic or radiological severity of CRSwNP [34].…”

Section: Metalloproteinasessupporting

confidence: 83%

Remodeling and Repair in Rhinosinusitis

Watelet

Dogné

Mullier

2015

Curr Allergy Asthma Rep

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Remodeling refers to the development of specific but potentially irreversible structural changes in tissue. Caucasian eosinophilic chronic rhinosinusitis (CRS) with polyps associated or not with cystic fibrosis was discriminated by edema from CRS without nasal polyps, characterized by extensive fibrotic fields. However, changes in epithelial and extracellular matrix structures are common findings in all types of chronic inflammatory diseases of upper airways, but rarely specific and highly variable in extend. Recent studies have shown that remodeling in CRS appears to occur in parallel, rather than purely subsequent to inflammation. Furthermore, some preferential remodeling associations can be recognized. Tremendous efforts have been put in research on coagulation factors, cytokines, growth factors, and proteases supporting all phases of upper airway remodeling. The current exploration of other CRS sub-groups and of the particular link with concomitant asthma aims to optimize the classification of CRS and its staging modes and to develop novel therapies.

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Section: Metalloproteinasessupporting

confidence: 83%

Remodeling and Repair in Rhinosinusitis

Watelet

Dogné

Mullier

2015

Curr Allergy Asthma Rep

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“…MMP1 cleaves fibrillar collagen, resulting in ECM disruption, and MMP2 and MMP9 degrade type IV collagen, the major structural component of basement membrane. A previous study reported a higher expression of MMP1 mRNA in patients with NPs than in healthy patients, suggesting that MMP1 could play an important role in CRSwNP . Also, several studies have shown that MMP2 and MMP9 values are higher in the CRSwNP and may result in fibrosis of the NPs .…”

Section: Discussionmentioning

confidence: 94%

Role of Toll‐like receptor 9 signaling on activation of nasal polyp–derived fibroblasts and its association with nasal polypogenesis

Park

Jin

Yeon

et al. 2018

Int Forum Allergy Rhinol

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“…36 However, the MMP-9 expression seems not to be correlated with the severity of nasal polyposis. 37,38 We have previously shown an increased MMP-9 concentration in the UAW of CF patients when compared to controls, and this concentration decreased after intravenous antibiotic therapy. 39 In the present study, if we consider that MMP-9 causes tissue damage and IgA is a protective antibody, 40 the IgA response in the UAW mucosa may counterbalance the MMP-9 production.…”

Section: Discussionmentioning

confidence: 96%

Antibody response against Pseudomonas aeruginosa and its relationship with immune mediators in the upper and lower airways of cystic fibrosis patients

Mauch

Hentschel

Aanæs

et al. 2020

Pediatric Pulmonology

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Background The upper airways (UAW) are a niche and a reservoir of Pseudomonas aeruginosa strains that cause chronic infection of the lower airways (LAW) in cystic fibrosis (CF). Here, we assessed the role of anti‐P. aeruginosa immunoglobulin A (IgA) and IgG antibodies in upper and lower airway infections in cystic fibrosis patients. Methods Nasal lavage fluid and induced sputum samples of 40 CF patients were microbiologically cultured. We searched for correlations between anti‐P. aeruginosa IgA and IgG levels, measured by enzyme‐linked immunosorbent assay (optical density), and unspecific immune mediators in both specimens. Results Anti‐P. aeruginosa IgA (median optical density: 0.953 vs 0.298) and IgG (0.120 vs 0.059) were significantly higher in nasal lavage than in sputum, but not significantly different between patients with and without chronic P. aeruginosa infection in UAW. Matrix metallopeptidase‐9 (MMP‐9) in nasal lavage and neutrophil elastase (NE) in sputum were predictors of IgA in nasal lavage and IgA in sputum, respectively. IgA was a predictor of myeloperoxidase (MPO) in nasal lavage. Tissue inhibitor of metalloproteinases‐1 (TIMP‐1) was a predictor of IgG in sputum. IgG, TIMP‐1, and NE in sputum were predictors of IgG in nasal lavage. Conclusion The anti‐P. aeruginosa IgA response was more prominent in CF patients' UAW, indicating a lower degree of inflammatory responses. Proteases may play a role in the anti‐P. aeruginosa humoral response in the upper and LAW, and anti‐P. aeruginosa IgG may be involved in the crosstalk between upper and lower airways in cystic fibrosis patients.

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Matrix metalloproteinases and their impact on sinusal extension in chronic rhinosinusitis with nasal polyps

Abstract: 2c.

Cited by 36 publications

References 14 publications

Remodeling and Repair in Rhinosinusitis

Remodeling and Repair in Rhinosinusitis

Role of Toll‐like receptor 9 signaling on activation of nasal polyp–derived fibroblasts and its association with nasal polypogenesis

Antibody response against Pseudomonas aeruginosa and its relationship with immune mediators in the upper and lower airways of cystic fibrosis patients

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