Matrix metalloproteinases and inflammatory markers in coronary artery ectasia: their relationship to severity of coronary artery ectasia

Doğan, Abdullah; Tüzün, Nurullah; Türker, Yasin; Akçay, Salaheddin; Kaya, Selçuk; Özaydın, Mehmet

doi:10.1097/mca.0b013e3283109079

Cited by 72 publications

(70 citation statements)

References 21 publications

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“…Koroner arter ektazisinin patogenezinde temel değişim media tabakasında meydana gelmektedir (24,25). KAE olgularının histopatolojik incelemesinde mediada yaygın dejenerasyon olduğu, metalloproteinaz enzim aktivitesinde artış olduğu, inflamatuvar süreçlerin etkili olabileceği belirtilmiştir (6,25).…”

Section: Discussionunclassified

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The relation of serum paraoxonase-1 activity with isolated coronary artery ectasia: an observational study

Altıparmak

Kaya²,

Sezen³

et al. 2012

Anadolu Kardiyol Derg

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Objective: Coronary artery ectasia (CAE) is a congenital or acquired anomaly characterized with localized or diffuse dilatations of coronary arteries. Paraoxonase (PON-1) is a high-density lipoprotein-cholesterol (HDLC) associated antioxidant enzyme that prevents atherosclerosis. The aim of this study was to investigate serum paraoxonase-1 enzyme activity (SPA) in patients with CAE in comparison patients with coronary artery disease (CAD) and normal coronary arteries. Methods: We have evaluated 44 patients with isolated IKAE, 40 cases with normal coronary arteries (NCA), 40 cases with critical CAD (CAD) and 40 cases with minimal CAD (MCAD) in this cross-sectional observational study. Demographic and biochemical data of patients were collected. SPA was determined spectrophotometrically. Among-group comparisons, ANOVA, Kruskal-Wallis and Chi-square tests were used; Bonferroni test was used for post-hoc analysis, Pearson's correlation analysis to determine the parameters associated with the SPA. Results: There were no differences among groups with regard to age, sex, presence of diabetes, hypertension and smoking (p>0.05 for all). The highest HDLC was detected in patients with NCA and lowest HDLC was detected in patients with CAD (respectively 52±15 mg/dL; 41±16 mg/d L, p=0.021). CAD and CAE groups were similar with respect to HDLC levels (p>0.05). The highest SPA level was detected in patients 307 ÖZET Amaç: Koroner arter ektazisi (KAE), konjenital veya edinsel olabilen koroner arter dilatasyonlarıdır. Paraoksonaz, yüksek-dansiteli lipoprotein-kolesterol (HDLK) aracılı antioksidan bir enzimdir ve düşük-dansiteli lipoprotein-kolesterol (LDLK)'ü bakır iyonu ve serbest radikallerin indüklemiş olduğu oksidasyondan koruyarak aterosklerozun önlenmesinde rol oynar. Bu çalışmada amaç izole KAE (İKAE) olan hastalarla normal koronerleri olan ve KAH olan hastalarda serum paroksanaz-1 enzim aktivitesini (SPA) açısından fark olup olmadığını araştırmak idi. Yöntemler: Bu enine-kesitli gözlemsel çalışmaya İKAE'si bulunan 44 hasta ile birlikte minimal koroner arter hastalığı (MKAH) olan 40; kritik koroner darlığı olan (KAH) 40 ve normal koroner arterleri olan (NKA) 40 olgu dâhil edildi. Tüm olgularda demografik veriler ve biyokimyasal veriler yanında SPA spektrofotometrik olarak değerlendirildi. Gruplar arası karşılaştırmalarda ANOVA, Kruskal-Wallis ve Ki-kare testleri, post-hoc analizler için Bonferroni testi, SPA'nın ilişkili parametrelerin belirlenmesinde Pearson korelasyon analizi kullanıldı. Bulgular: İKAE ve diğer gruplar arasında, yaş, cinsiyet, diyabet, hipertansiyon varlığı ve sigara içiciliği açısından istatistiksel anlamlı fark yoktu (hepsi için p>0.05). Gruplar arasında HDLK yönünden fark vardı (p=0.021). En yüksek SPA NKA grubunda saptanırken en düşük SPA KAH grubunda saptandı (sırası ile 250.78±59.37U/L; 163.39±49.28 U/L; p=0.005). Post-hoc analizlerde bu farkın İKAE grubu ile NKA grubu ve KAH grubu ile NKA grubu arasında olduğu gözlendi [p=0.005 (NKA ve İKAE); p=0.0045 (NKA ve MKAH ); p=0.007 (NKA ve KAH)]....

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Section: Discussionunclassified

“…KAE olgularının histopatolojik incelemesinde mediada yaygın dejenerasyon olduğu, metalloproteinaz enzim aktivitesinde artış olduğu, inflamatuvar süreçlerin etkili olabileceği belirtilmiştir (6,25). KAE olan olgularda ailevi hiperkolesteroleminin daha sık görüldüğü belirtilmiştir (8).…”

Section: Discussionunclassified

The relation of serum paraoxonase-1 activity with isolated coronary artery ectasia: an observational study

Altıparmak

Kaya²,

Sezen³

et al. 2012

Anadolu Kardiyol Derg

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“…However, today, various evidence, including the inverse correlation between diabetes mellitus, age and CAE, as well as higher levels of CRP, MMPs in the CAE than the CAD, the geater involvement of the right coronary artery in the CAE compared the anterior interventricular artery in CAD, lead us to think that the CAE could be a separate entity compared to coronary atherosclerosis, despite it determines similar symptoms and harmful insults to myocardial tissue [25].…”

Section: Discussion:-mentioning

confidence: 99%

“…Among these, an important role was attributed to MMPs [1,2,19,23,24] that determine, in response to biochemical and local hemodynamic insults, abnormal extracellular matrix degradation promoting an exuberant expansive remodeling of the vascular wall and thus the development of CAE [25].…”

Section: Discussion:-mentioning

confidence: 99%

Matrix Metalloproteinases and Coronary Artery Ectasia.

Levantino¹,

Raspanti²,

Evola³

et al. 2017

IJAR

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Background: Coronary artery ectasia is the abnormal dilatation of one or more coronary segments. Although the pathogenetic mechanisms underlying CAE are largely unknown, it seems that some of the extracellular matrix degrading enzymes such as matrix metalloproteinases (mmps) can play an important role in the development of this condition. The aim of our study was to evaluate the relationship between MMP-9 and the development of CAE as well as the role played by the inflammatory process in this condition. Materials And Methods: In our retrospective study we have enrolled a series of 79 patients: 47 presented, on coronary angiography, focal or diffuse ectasia of coronary arteries (cases), 32 had a free coronary tree or without hemodynamically significant stenosis (controls). All patients were subjected to blood sampling for the dosage of MMP-9 and Creactive protein (CRP). Results: In our study we found that the most involved coronary artery in CAE was the right coronary artery. Serum levels of MMP-9 were higher in the patients with CAE (5.011 mcg / ml vs. 3.93 mcg / ml, p = 0,07) although not statistically significant, in direct proportion to the number of involved vessels (p = 0.025). Serum CRP levels were higher in patients with CAE (5.12 mg / dl vs. 2.18 mg / dl, p = 0.4) although not statistically significant, in direct proportion to the number of involved vessels (p = 0.001). Conclusions: We found a possible relationship between elevated levels of MMP-9 and CAE, as well as the relationship between levels of MMP-9 and severity of the CAE. Furthermore we found a possible relationship between elevated CRP levels and CAE and there was a directly proportional relationship between the increase of CRP and extension of the CAE.

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“…16,18,21,24 Studies have documented well the role of chronic inflammation in triggering arterial ectasia and microaneurysm formation in the coronary artery. 7,21,24 Studies have also associated ICH with similar chronic inflammatory abbreviatioNs CKD = chronic kidney disease; COM = chronic osteomyelitis; HR = hazard ratio; ICH = intracerebral hemorrhage; IR = incidence rate; IRR = incidence rate ratio; NHI = National Health Insurance; RA = rheumatoid arthritis; SLE = systemic lupus erythematosus; VZV = varicella-zoster virus. obJect Inflammation may provoke cerebral arteriolar ectasia, inducing microaneurysm formation and further promoting intracerebral hemorrhage (ICH).…”

mentioning

confidence: 99%

Increased risk of intracerebral hemorrhage among patients with chronic osteomyelitis

Tseng¹,

Huang²,

Muo

et al. 2015

JNS

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Stroke, either ischemic stroke or intracerebral hemorrhage (ICH), is the leading cause of disability and one of the leading causes of death in adults. 10,28,31 Patients with ICH are at higher risk of disability than those with ischemic stroke, inclusive of greater economic and health care burdens. Exhibiting in 10%-20% of all strokes, ICH has been associated with both noninfectious and infectious factors. Studies have shown that intravenous drug use-related systemic infections increase the risk of cerebral vascular infection and subsequent rupture of mycotic aneurysms in cerebral arterioles. 9,15,32 Among noninfectious factors, pathological changes in the cerebral arterioles, including proliferation and death of arteriolar smooth muscle cells and arteriolar ectasia with microaneurysm formation 31 in the cerebral arterioles, may subsequently lead to the rupture of arteriolar microaneurysms, causing ICH. 10,28,31 These noninfectious pathological changes can be triggered by some conventional risk factors for ICH, such as hypertension, diabetes, hyperlipidemia, and chronic kidney disease (CKD). 16,18,20,21,24 However, risk factors for 10%-25% of ICH patients remain unclear, especially in the younger population. 16,18,21,24 Studies have documented well the role of chronic inflammation in triggering arterial ectasia and microaneurysm formation in the coronary artery. 7,21,24 Studies have also associated ICH with similar chronic inflammatory abbreviatioNs CKD = chronic kidney disease; COM = chronic osteomyelitis; HR = hazard ratio; ICH = intracerebral hemorrhage; IR = incidence rate; IRR = incidence rate ratio; NHI = National Health Insurance; RA = rheumatoid arthritis; SLE = systemic lupus erythematosus; VZV = varicella-zoster virus. obJect Inflammation may provoke cerebral arteriolar ectasia, inducing microaneurysm formation and further promoting intracerebral hemorrhage (ICH). Chronic osteomyelitis (COM) is an inflammatory disorder for which study of its role in ICH is lacking. This study explored whether COM increases the risk of ICH. methods From Taiwan national insurance inpatient claims, 22,052 patients who were newly diagnosed with COM between 1997 and 2010 were identified; 88,207 age and sex frequency-matched subjects without COM were selected at random for comparison. Risks of ICH associated with COM and comorbidities, including hypertension, diabetes, hyperlipidemia, chronic kidney disease, and drug abuse, were assessed by the end of 2010. results The incidence of ICH was 1.68 times higher in the COM cohort than in the comparison cohort, with an adjusted hazard ratio (HR) of 1.50 (95% CI 1.29-1.74) estimated in the multivariable Cox model. Age-specific analysis showed that the HR of ICH for COM patients decreased with age, with an adjusted HR of 3.28 (95% CI 1.88-5.75) in the < 40-year age group, which declined to 1.11 (95% CI 0.88-1.40) in the elderly. The incidence of ICH increased with the severity of COM; for those with severe COM the adjusted HR was 4.42 (95% CI 3.31-5.89). For subjects without comorbi...

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Matrix metalloproteinases and inflammatory markers in coronary artery ectasia: their relationship to severity of coronary artery ectasia

Abstract: Our results suggest that the increased level of MMP-3, MMP-9, and IL-6 may be responsible for ectasia formation in patients with CAE.

Cited by 72 publications

References 21 publications

The relation of serum paraoxonase-1 activity with isolated coronary artery ectasia: an observational study

The relation of serum paraoxonase-1 activity with isolated coronary artery ectasia: an observational study

Matrix Metalloproteinases and Coronary Artery Ectasia.

Increased risk of intracerebral hemorrhage among patients with chronic osteomyelitis

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