Matrix metalloproteinase-responsive collagen-oxidized hyaluronic acid injectable hydrogels for osteoarthritic therapy

Yi, Xueling; Xu, Zhilang; Liu, Qisong; Zhou, Hongmei; Long, Yuan; Li, Defu; Zhao, Lei; Mu, Changdao; Ge, Liming

doi:10.1016/j.bioadv.2022.212804

Cited by 19 publications

(5 citation statements)

References 53 publications

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“…The 1 H NMR spectra of OHA revealed that new peaks appeared at 4.90, 5.00, and 5.10 ppm, which corresponded to the hemiacetalic proton between the aldehydes and the neighboring hydroxyl groups. The proton signal at 9.50 ppm belonged to the proton in the aldehyde 31 (Fig. S2A, ESI †).…”

Section: Resultsmentioning

confidence: 99%

Metal-phenolic self-assembly shielded probiotics in hydrogel reinforced wound healing with antibiotic treatment

Zhou

Zou

et al. 2023

Mater. Horiz.

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Section: Resultsmentioning

confidence: 99%

Metal-phenolic self-assembly shielded probiotics in hydrogel reinforced wound healing with antibiotic treatment

Zhou

Zou

et al. 2023

Mater. Horiz.

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“…The hydrophilic group of the gelatin and hyaluronate polymers and high porosity in the fabricated hydrogel can effectively retain moisture. 52 These features absorb wound exudate, maintaining a moist environment and promoting epithelialization. 53 All hydrogels showed a high swelling capacity of more than 1300% (Fig.…”

Section: Preparation and Characterization Of Foh Hydrogelsmentioning

confidence: 99%

Multifunctional hydrogel dressing based on fish gelatin/oxidized hyaluronate for promoting diabetic wound healing

Park,

Kim,

Jang

et al. 2024

J. Mater. Chem. B

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“…OHA was prepared by the periodate oxidation assay. 33 ε-PL-SH was prepared by a previously reported method with appropriate modification. 34 All details are shown in Supporting Information.…”

Section: Preparation Of Oxidized Hyaluronic Acid (Oha) and Cysteine-m...mentioning

confidence: 99%

Antibacterial Conductive Collagen-Based Hydrogels for Accelerated Full-Thickness Wound Healing

Lin

et al. 2023

ACS Appl. Mater. Interfaces

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Antibacterial conductive hydrogels have been extensively utilized in tissue repair and regeneration on account of their unique electrochemical performances and advantages of anti-pathogenic bacterial infection. Here, multi-functional collagen-based hydrogels (CHLY) with adhesivity, conductivity, and antibacterial and antioxidant activities were developed by introducing cysteine-modified ε-poly(l-lysine) (ε-PL-SH) and in situ-polymerized polypyrrole (PPy) nanoparticles to induce full-thickness wound healing. CHLY hydrogels have a low swelling ratio, good compressive strength, and viscoelasticity due to chemical crosslinking, chelation, physical interaction, and nano-reinforcements in the matrix network of hydrogels. CHLY hydrogels possess excellent tissue adhesion ability, low cytotoxicity, enhanced cell migration ability, and good blood coagulation performance without causing hemolysis. Interestingly, the chemical conjugation of ε-PL-SH in the hydrogel matrix gives hydrogels an inherently robust and broad-spectrum antibacterial activity, while the introduction of PPy endows hydrogels with superior free radical scavenging capacity and good electroactivity. Significantly, CHLY hydrogels have advantages in alleviating persistent inflammatory response as well as promoting angiogenesis, epidermis regeneration, and orderly collagen deposition at the wound sites through their multi-functional synergies, thus effectively accelerating full-thickness wound healing and improving wound healing quality. Overall, our developed multi-functional collagen-based hydrogel dressing demonstrates promising application prospects in the field of tissue engineering to induce skin regeneration.

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Matrix metalloproteinase-responsive collagen-oxidized hyaluronic acid injectable hydrogels for osteoarthritic therapy

Cited by 19 publications

References 53 publications

Metal-phenolic self-assembly shielded probiotics in hydrogel reinforced wound healing with antibiotic treatment

Metal-phenolic self-assembly shielded probiotics in hydrogel reinforced wound healing with antibiotic treatment

Multifunctional hydrogel dressing based on fish gelatin/oxidized hyaluronate for promoting diabetic wound healing

Antibacterial Conductive Collagen-Based Hydrogels for Accelerated Full-Thickness Wound Healing

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