Matrix metalloproteinase (MMP)-7 in salivary gland cancer

Luukkaa, Heikki; Klemi, Pekka; Hirsimäki, Pirkko; Vahlberg, Tero; Kivisaari, Atte; Kähäri, Veli‐Matti; Grénman, Reidar

doi:10.3109/02841860903287197

Cited by 32 publications

(26 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is supported by similar results from other tumor types. Luukaa and coworkers showed that high expression of MMP-7 in acinic cell carcinomas and mucoepidermoid carcinomas of the salivary glands, was associated with a better overall survival [19]. In consistency, Ito et al found in papillary thyroid carcinoma that low tumor cell MMP-7 and MMP-11 expression was associated with aggressive tumor characteristics indicative of poor prognosis [20].…”

Section: Discussionmentioning

confidence: 92%

Overexpression of matrix metalloproteinase-7 and -9 in NSCLC tumor and stromal cells: Correlation with a favorable clinical outcome

et al. 2012

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 92%

Overexpression of matrix metalloproteinase-7 and -9 in NSCLC tumor and stromal cells: Correlation with a favorable clinical outcome

et al. 2012

View full text Add to dashboard Cite

“…MMP7 expression was associated with favorable prognosis of malignant neoplasms of ovary and salivary gland [11,20], while in cholangiocarcinoma and esophageal squamous cell carcinoma, CD133 negativity was related to advanced tumor stage and poor prognosis [4,16]. Negative Oct3/4 expression was correlated with invasion depth, lymph node metastasis, and lymphatic invasion of gastric cancer [13].…”

Section: Discussionmentioning

confidence: 99%

Predictive value for lymph node metastasis of epithelial-mesenchymal transition and cancer stem cell marker expression in early gastric cancer

Nam

Yoon

Lee

et al. 2017

Pathology - Research and Practice

View full text Add to dashboard Cite

“…However, the limit of detection (LOD) achieved by this assay was 5 nM, approximately equivalent to the critical level of MMP-7 related to salivary gland cancer. 12 Moreover, performance of this MMP-7 assay in clinical sample matrices was not demonstrated.…”

mentioning

confidence: 99%

Detection of Matrilysin Activity Using Polypeptide Functionalized Reduced Graphene Oxide Field-Effect Transistor Sensor

Chen

Huang

et al. 2016

Anal. Chem.

View full text Add to dashboard Cite

Detection of matrilysin (MMP-7) activity using polypeptide functionalized reduced graphene oxide field-effect transistor sensor.This item was submitted to Loughborough University's Institutional Repository by the/an author. Citation: CHEN, H. ... et al, 2016. Detection of matrilysin (MMP-7) activity using polypeptide functionalized reduced graphene oxide field-effect transistor sensor. Analytical Chemistry, 88 (6) Just Accepted "Just Accepted" manuscripts have been peer-reviewed and accepted for publication. They are posted online prior to technical editing, formatting for publication and author proofing. The American Chemical Society provides "Just Accepted" as a free service to the research community to expedite the dissemination of scientific material as soon as possible after acceptance. "Just Accepted" manuscripts appear in full in PDF format accompanied by an HTML abstract. "Just Accepted" manuscripts have been fully peer reviewed, but should not be considered the official version of record. They are accessible to all readers and citable by the Digital Object Identifier (DOI®). "Just Accepted" is an optional service offered to authors. Therefore, the "Just Accepted" Web site may not include all articles that will be published in the journal. After a manuscript is technically edited and formatted, it will be removed from the "Just Accepted" Web site and published as an ASAP article. Note that technical editing may introduce minor changes to the manuscript text and/or graphics which could affect content, and all legal disclaimers and ethical guidelines that apply to the journal pertain. ACS cannot be held responsible for errors or consequences arising from the use of information contained in these "Just Accepted" manuscripts. ABSTRACT: A novel approach for rapid and sensitive detection of matrilysin (MMP-7, a biomarker involved in the degradation of various macromolecules) based on polypeptide (JR2EC) functionalized reduced graphene oxide (rGO) field effect transistor (FET) is reported. MMP-7 specifically digests negatively charged JR2EC immobilized on rGO, thereby modulating the conductance of rGO-FET. The proposed assay enabled detection of MMP-7 at clinically relevant concentrations with a limit of detection (LOD) of 10 ng/mL (400 pM), attributed to the significant reduction of the net charge of JR2EC upon digestion by MMP-7. Quantitative detection of MMP-7 in human plasma was further demonstrated with a LOD of 40 ng/mL, illustrating the potential for the proposed methodology for tumor detection and carcinoma diagnostic (e.g. lung cancer and salivary gland cancer). Additionally, excellent specificity of the proposed assay was demonstrated using matrix metallopeptidase 1 (MMP-1), a protease of the same family. With appropriate selection and modification of polypeptides, the proposed assay could be extended for detections of other enzymes with polypeptide digestion capability. Detection of Matrilysin (MMP-7) Activity Using Polypeptide Functionalized Reduced Graphene Oxide Field-Effect Transistor Sensor

show abstract

Matrix metalloproteinase (MMP)-7 in salivary gland cancer

Abstract: MMP-7 is associated with the prognosis of patients with acinic cell and mucoepidermoid carcinoma.

Cited by 32 publications

References 22 publications

Overexpression of matrix metalloproteinase-7 and -9 in NSCLC tumor and stromal cells: Correlation with a favorable clinical outcome

Overexpression of matrix metalloproteinase-7 and -9 in NSCLC tumor and stromal cells: Correlation with a favorable clinical outcome

Predictive value for lymph node metastasis of epithelial-mesenchymal transition and cancer stem cell marker expression in early gastric cancer

Detection of Matrilysin Activity Using Polypeptide Functionalized Reduced Graphene Oxide Field-Effect Transistor Sensor

Contact Info

Product

Resources

About