Matrix metalloproteinase inhibitory properties of benzalkonium chloride stabilizes adhesive interfaces

Sabatini, Camila; Patel, Shaival K.

doi:10.1111/eos.12089

Cited by 33 publications

(35 citation statements)

References 20 publications

(25 reference statements)

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“…Inhibitors of endogenous dentin proteases other than CHX, such as the quaternary ammonium surface-acting benzalkonium chloride (BAC) 124,125,126,127 the tetracyclines (TCs) and their antimicrobially inactive analogs (minocycline, for now), 71,84,128,129,130 bisphosphonates (batimastat, galardin, and zoled ron ate), 93,129,131,132 g reen tea poly phenol epigallocatechin-3-gallate (EGCG), 40,133,134 and the chelating agent ethylenediaminetetraacetic acid (EDTA) 135,136,137 are being studied as better alternatives associated with dentin hybrid layer preservation.…”

Section: Enzymatic Inhibitorsmentioning

confidence: 99%

Bonding efficiency and durability: current possibilities

et al. 2017

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Bonding plays a major role in dentistry nowadays. Dental adhesives are used in association with composites to solve many restorative issues. However, the wide variety of bonding agents currently available makes it difficult for clinicians to choose the best alternative in terms of material and technique, especially when different clinical situations are considered. Moreover, although bonding agents allow for a more conservative restorative approach, achieving a durable adhesive interface remains a matter of concern, and this mainly due to degradation of the bonding complex in the challenging oral environment. This review aims to present strategies that are being used or those still in development which may help to prevent degradation. It is fundamental that professionals are aware of these strategies to counteract degradation as much as possible. None of them are efficient to completely solve this problem, but they certainly represent reasonable alternatives to increase the lifetime of adhesive restorations.

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Section: Enzymatic Inhibitorsmentioning

confidence: 99%

Bonding efficiency and durability: current possibilities

et al. 2017

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“…Commercially available BAC-containing etchants can be used without affecting immediate bond strength to enamel or dentin. 96 BAC also inhibits dentinal MMPs [97][98][99] and may also improve the durability of dentin bonding when incorporated either into the etchant or the adhesive. 99 Tetracyclines and their antimicrobially inactive analogs inhibit MMP with their cationic chelating properties and have been shown to inhibit salivary and dentinal MMPs as well.…”

Section: Enzyme Inhibitorsmentioning

confidence: 99%

Dentin Bonding: Can We Make it Last?

Tjäderhane

2015

Operative Dentistry

170

144

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Bond strength to dentin decreases with time because of the hydrolytic degradation of the hybrid layer components dentin collagen and adhesive resin. Inhibition of enzymes responsible for the collagen degradation may improve the bond strength durability. SUMMARYIn dentin bonding, contemporary dental adhesive systems rely on formation of the hybrid layer, a biocomposite containing dentin collagen and polymerized resin adhesive. They are usually able to create at least reasonable integrity of the hybrid layer with high immediate bond strength. However, loss of dentinbonded interface integrity and bond strength is commonly seen after aging both in vitro and in vivo. This is due to endogenous collagenolytic enzymes, matrix metalloproteinases, and cysteine cathepsins, responsible for the timedependent loss of hybrid layer collagen. In addition, the hydrophilic nature of adhesive systems creates problems that lead to suboptimal hybrid layers. These problems include, for example, insufficient resin impregnation of dentin, phase separation, and a low rate of polymerization, all of which may reduce the longevity of the bonded interface.Preservation of the collagen matrix integrity by inhibition of endogenous dentin proteases is key to improving dentin bonding durability. Several approaches to retain the integrity of the hybrid layer and to improve the long-term dentin bond strength have been tested. These include the use of enzyme inhibitors, either separately or as incorporated into the adhesive resins; increase of collagen resistance to enzymatic degradation; and elimination of water from the interface to slow down or eliminate hydrolytic loss of the hybrid layer components. This review looks at the principles, current status, and future of the different techniques designed to prevent the loss of hybrid layer and bond strength.

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“…40,56,85,86 Sabatini and Patel 86 evaluated the effects of different concentrations of BAC on the preservation of adhesive interfaces by using two etch-and-rinse adhesives (Optibond Solo Plus and All-Bond 3). They reported improvement in the bond strength in groups pretreated with 0.5% BAC and 1.0% BAC and using Optibond Solo Plus, and in groups pretreated with 0.25 and 0.5% BAC and using All-Bond 3.…”

Section: Effects On Restorative Treatmentmentioning

confidence: 99%

Effects and Effectiveness of Cavity Disinfectants in Operative Dentistry: A Literature Review

Bin-Shuwaish¹

2016

The Journal of Contemporary Dental Practice

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The degree of success in the elimination of bacteria during cavity preparation and prior to the insertion of a restoration may increase the longevity of the restoration and therefore the success of the restorative procedure. The complete eradication of bacteria in a caries-affected tooth, during cavity preparation, is considered a difficult clinical task. In addition to weakening the tooth structure, attempts to excavate extensive carious tissue completely, by only mechanical procedures, may affect the vitality of the pulp. Therefore, disinfection of the cavity preparation after caries excavation can aid in the elimination of bacterial remnants that can be responsible for recurrent caries, postoperative sensitivity, and failure of the restoration. However, the effects of disinfectants on the restorative treatment have been a major concern for dental clinicians and researchers. This review aims to explore existing literature and provide information about different materials and techniques that have been used for disinfecting cavity preparations and their effects and effectiveness in operative dentistry and, therefore, helps dental practitioners with clini cal decision to use cavity disinfectants during restorative procedures. Antimicrobial effectiveness and effects on the pulp and dental restorations, in addition to possible side effects, were all reviewed in this paper.

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Matrix metalloproteinase inhibitory properties of benzalkonium chloride stabilizes adhesive interfaces

Cited by 33 publications

References 20 publications

Bonding efficiency and durability: current possibilities

Bonding efficiency and durability: current possibilities

Dentin Bonding: Can We Make it Last?

Effects and Effectiveness of Cavity Disinfectants in Operative Dentistry: A Literature Review

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