Matrix metalloproteinase expression in cytokine stimulated human dermal fibroblasts

Polymorphisms in Genes Involved in Inflammatory and Angiogenic Pathways and the Risk of Hemorrhagic Presentation of Brain Arteriovenous Malformations

“…1 Local IL6 release by endothelial cells within the BAVM nidus may therefore contribute to vascular wall instability by stimulating release and activation of MMP. 23,24 If the IL6-174G allele increases local IL6 production, then BAVM hemorrhage may result from MMPmediated weakening of the vascular wall already compromised by hemodynamic stress.…”

Induction of Host Matrix Metalloproteinases byBorrelia burgdorferiDiffers in Human and Murine Lyme Arthritis

“…Fibroblasts and pulmonary artery cells contain the machinery to produce at least some MMPs (MMP-1, -2, and -19 and TIMP-1, etc.) (18,21); the lack of induction in the presence of B. burgdorferi suggests either that these cells may lack a specific receptor for recognizing B. burgdorferi or that other critical elements in B. burgdorferi-related induction pathways of MMPs are absent. Cell-specific induction of MMPs may help to explain why pathological inflammation and degradation are seen in certain tissues but not in others despite the fact that B. burgdorferi is typically widely disseminated and can be recovered from multiple sites.…”

Potential Role of Fibroblast-Like Synoviocytes in Joint Damage Induced by Brucella abortus Infection through Production and Induction of Matrix Metalloproteinases

“…Since GM-CSF and IL-6 are also known to induce MMP production by different cell types (8,26,46) and both factors are produced by Brucella-infected FLS ( Fig. 2A and B), we decided to test their potential role as mediators of the MMP-9 induction by culture supernatants from infected FLS.…”