Matrix metalloproteinase-9 genetic variations affect MMP-9 levels in obese children

Belo, Vanessa A.; Souza-Costa, Debora C.; Luizon, Marcelo R.; Lanna, Carla Márcia Moreira; Carneiro, P.; Izidoro-Toledo, Tatiane C.; Ferraz, Karina Coutinho; Tanus‐Santos, José Eduardo

doi:10.1038/ijo.2011.169

Cited by 37 publications

(26 citation statements)

References 29 publications

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“…[10][11][12] Furthermore, MMP9 is highly expressed in the weak regions of atherosclerotic plaques and may be causally involved in plaque rupture. [13][14][15] The increase in plasma concentrations of MMP9 may be a predictor of cardiovascular disease risk and plasma MMP9…”

Section: Introductionmentioning

confidence: 99%

Association of MMP‐9 gene polymorphisms with nephrolithiasis patients

Mehde

Mehdi

Yusof

et al. 2017

Clinical Laboratory Analysis

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Background Nephrolithiasis is one of the causes which lead to chronic kidney disease (CKD). Matrix metalloproteinases (MMPs) are endopeptidases degrading extracellular matrix which correlate with the pathogenesis of atherosclerosis. The current study was designed to analyze the association of (R279Q, C1562T) polymorphism of MMP‐9 with nephrolithiasis patients. Methods Genotyping of MMP‐9/R279Q and of MMP‐9/C1562T polymorphism were carried out by PCR‐based restriction digestion method. Serum level of MMP‐9, oxidative stress marker, MDA, and uric acid were measured in patients and control. Results Allele frequencies of the MMP‐9/C1562T polymorphism for C and T allele were 71.25% and 28.75% in patients, 87.08% and 12.92% in control respectively. The homozygote TT was more frequent in the nephrolithiasis patients group, while T allele frequency was significantly higher in the nephrolithiasis patients group than in the control group. The patients with CT and TT genotype showed a significant increase in serum MMP‐9, Total Oxidant Status (TOS), Oxidative Stress Index (OSI), Malondialdehyde (MDA), and uric acid when compared to CC genotype in patients with nephrolithiasis. The R279Q polymorphism site with regard to the relationship with nephrolithiasis was not significant. Conclusion The result indicates that patients with TT genotype had an increased risk of stones. Also, the results demonstrate that TT allele of the C1562T polymorphism in the MMP‐9gene is related with an increase of oxidative stress in nephrolithiasis patients and may possibly impose a risk for cardiovascular diseases in patients with TT genotype of MMP‐9.

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Section: Introductionmentioning

confidence: 99%

Association of MMP‐9 gene polymorphisms with nephrolithiasis patients

Mehde

Mehdi

Yusof

et al. 2017

Clinical Laboratory Analysis

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“…Results were expressed as nanograms or picograms per mL. Values below detection limit were considered as 0 [15, 16]. …”

Section: Methodsmentioning

confidence: 99%

Expression of Adiponectin Receptors on Peripheral Blood Leukocytes of Hypertensive Children Is Associated with the Severity of Hypertension

Gackowska

Litwin

Trojanek

et al. 2015

BioMed Research International

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The aim of the study was to find out whether peripheral blood leukocyte adiponectin receptors 1 and 2 (AdipoR1, AdipoR2) protein expression patterns (flow cytometry) differ between the primary hypertension children (n = 57) and healthy controls (n = 19) and if their expression levels are related to selected clinical parameters. The group of 26 patients [AdipoR(−)] showed lower and the group of 31 patients [AdipoR(+)] showed higher AdipoRs protein expression than the control and each other (P < 0.01 for neutrophils, P < 0.05 for monocytes). The AdipoR(+) leukocytes expressed higher AdipoR1 mRNA levels (RT-PCR) than AdipoR(−) ones and controls (P = 0.022 and P = 0.007, resp.). Despite greater BMI, the AdipoR(−) patients had unchanged serum adiponectin levels. In contrast, AdipoR(+) patients had lower serum adiponectin concentrations than the AdipoR(−) ones and controls (P < 0.001). The AdipoR(+) patients had higher blood pressure (P = 0.042) and greater carotid intima-media thickness (P = 0.017) than the AdipoR(−) ones. The stage of hypertension was associated with increased neutrophil but not monocyte AdipoR1 density (AdipoR1 MFI) (P < 0.05). Severe ambulatory hypertension was presented more often in AdipoR(+) patients than in AdipoR(−) ones (51.6% versus 26.9%, resp.; P < 0.01). In conclusion, neutrophil AdipoRs upregulation was associated with early stages of vascular injury, hypertension severity, and low serum levels of adiponectin.

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“…Mounting evidence suggests that MMP-9 gene polymorphisms may affect MMP-9 levels, the progression of disease conditions and therapeutic responses (Demacq et al, 2009;Jacob-Ferreira et al, 2010b;Lacchini et al, 2010;Belo et al, 2012;Palei et al, in press). Relevant functional MMP-9 polymorphisms include the C(−1562)T polymorphism (Zhang et al, 1999), a microsatellite −90(CA) n (13-25 repeats) in promoter region (Shimajiri et al, 1999), and the Q279R in exon 6 (Allan et al, 1995).…”

Section: Introductionmentioning

confidence: 93%

Specific matrix metalloproteinase 9 (MMP-9) haplotype affect the circulating MMP-9 levels in women with migraine

Martins-Oliveira

Gonçalves

Speciali

et al. 2012

Journal of Neuroimmunology

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We investigated whether three relevant polymorphisms (C-1562T, microsatellite -90(CA)(14-24), and Q279R) in the MMP-9 gene, or MMP-9 haplotypes, are associated with migraine and affect MMP-9 and tissue inhibitor of MMPs (TIMP)-1 levels in patients with migraine. We studied 102 healthy women (controls) and 187 women with migraine (141 without aura - MWA, and 46 with aura - MA). Patients with MWA had higher plasma MMP-9 concentrations than patients with MA. Patients with MA had the highest TIMP-1 and lowest MMP-9/TIMP-1 ratios. The MMP-9 "C L Q" haplotype was associated with higher plasma MMP-9 concentrations in migraine patients.

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Matrix metalloproteinase-9 genetic variations affect MMP-9 levels in obese children

Cited by 37 publications

References 29 publications

Association of MMP‐9 gene polymorphisms with nephrolithiasis patients

Association of MMP‐9 gene polymorphisms with nephrolithiasis patients

Expression of Adiponectin Receptors on Peripheral Blood Leukocytes of Hypertensive Children Is Associated with the Severity of Hypertension

Specific matrix metalloproteinase 9 (MMP-9) haplotype affect the circulating MMP-9 levels in women with migraine

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