Matrix metalloproteinase-9 Gene-1562C&gt;T Gene Polymorphism and Coronary Artery Disease in the Chinese Han Population: A Meta-Analysis of 5468 Subjects

Li, Yanyan; Yang, Xinxing; Zhou, Yanhong; Gong, Ge; Geng, Hong‐yu; Kim, Hee Jin; Zhou, Chuanwei; Qian, Yun; Wang, Xiangming; Wu, Jun

doi:10.3389/fphys.2016.00212

Cited by 6 publications

(5 citation statements)

References 27 publications

(28 reference statements)

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“…In 2016, a metaanalysis was conducted on 10 case-control studies to assess the possible relationship between the MMP-9 (C1562T) SNP and CAD in the Chinese Han population. This study indicated that all genetic comparisons of the MMP-9 (C1562T) SNP increased the risk of CAD in the Chinese Han population [70]. In the current meta-analysis, association between SNPs of the MMP-9 gene family, including MMP-9 (C1562T), MMP-9 (R279Q), MMP-9 (P574R), and MMP-9 (R668Q) polymorphisms and risk of CAD was evaluated.…”

Section: Discussionmentioning

confidence: 93%

The association between Matrix Metallo-proteinases-9 (MMP-9) gene family polymorphisms and risk of Coronary Artery Disease (CAD): a systematic review and meta-analysis

Hassanzadeh-Makoui

Razi

Aslani

et al. 2020

BMC Cardiovasc Disord

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Background: We performed a systematic review and meta-analysis of the Matrix metalloproteinases (MMP)-9 (C1562T), MMP-9 (R279Q), MMP-9 (P574R) and MMP-9 (R668Q) polymorphisms and risk of Coronary Artery Disease (CAD). Methods: After a systematic literature search, pooled odds ratio (OR) and their corresponding 95% confidence interval (CI) were used to evaluate the strength of the association. Results: We identified 40 studies with 11,792 cases and 8280 controls for C1562T, 7 case-control studies with 5525 cases and 2497 controls for R279Q, 2 studies with 1272 cases and 785 controls for P574R, and 2 studies with 1272 cases and 785 controls for R668Q. MMP-9 (C1562T) polymorphism was associated with increased risk of CAD under dominant model (OR = 1.41, P < 0.001), recessive model (OR = 1.59, P < 0.001), allelic model (OR = 1.38, P < 0.001), TT vs. CC model (OR = 1.70, P < 0.001), and CT vs. CC model (OR = 1.35, P < 0.001). Moreover, the subgroup analysis based on the continent of the study populations in this SNP indicated strong significant association in Asians but not in Europeans. Subgroup analysis was not performed in Africa, America and Oceania, due to lack of sufficient data. Conclusions: Our meta-analysis revealed that MMP-9 (C1562T) SNP conferred a susceptibility risk for CAD in the overall analysis and Asian population. The overall analysis and subgroup analysis of the other three SNPs reject the association between MMP-9 polymorphisms and the risk of CAD. Although the results should interpret with caution because of small sample size of included studies in these three SNPs.

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Section: Discussionmentioning

confidence: 93%

The association between Matrix Metallo-proteinases-9 (MMP-9) gene family polymorphisms and risk of Coronary Artery Disease (CAD): a systematic review and meta-analysis

Hassanzadeh-Makoui

Razi

Aslani

et al. 2020

BMC Cardiovasc Disord

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“…Furthermore, environmental factors such as diet, smoking, diabetes, and metabolism diseases also play significant roles in CAD development. The microeffects of many other genes relating to CAD development have yet to be fully understood (i.e., matrix metalloproteinase-9 gene-1562C>T polymorphism, TGF- β 1 gene−509C/T Polymorphism) ( 33 , 34 ). PCSK9 gene D129G, S127R, R496W, and R218S polymorphisms also influence the PCSK9 activity and CAD susceptibility ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

PCSK9 Gene E670G Polymorphism and Coronary Artery Disease: An Updated Meta-Analysis of 5,484 Subjects

Wang

Yang

et al. 2020

Front. Cardiovasc. Med.

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“…Several studies also investigated the association between MMP-9 gene and CAD. Zhang et al 22 provided evidence that rs3918242 polymorphism may have modification effects on CAD susceptibility in Asians, but another meta-study 23 suggested that the MMP-9-rs3918242 was associated with an increased CAD trend in Chinese Han population. Therefore, the Han Chinese-1562T carriers may increase the risk of CAD.…”

Section: Discussionmentioning

confidence: 99%

Matrix metalloproteinase-9 gene polymorphisms and their interaction with environment on subarachnoid hemorrhage risk

Wang

Song

et al. 2018

Exp Biol Med (Maywood)

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The current study aimed to investigate the relations of three single nucleotide polymorphisms of matrix metalloproteinase-9 gene, and single nucleotide polymorphisms-smoking interaction to subarachnoid hemorrhage risk. The optimal pattern of the interaction among single nucleotide polymorphisms and smoking was selected by generalized multifactor dimensionality reduction. The association between the three single nucleotide polymorphisms within the matrix metalloproteinase-9 gene was analyzed by logistic regression test. As well as genetic risk of subarachnoid hemorrhage interactions with smoking, the risk of subarachnoid hemorrhage in carriers with the rs3918242 (T) was significantly higher than in carriers carrying CC (genotype: CT + TT vs. CC), adjusted OR (95% CI) = 1.58 (1.25-2.03), and in carriers carrying rs17576- (genotype: AG + GG vs. AA), adjust OR (95% CI) = 1.62 (1.19-2.13). However, after adjusting for covariates, we did not find any direct association between rs17577 and subarachnoid hemorrhage risk. The generalized multifactor dimensionality reduction model shows a potential relation between rs3918242 and smoking risk for subarachnoid hemorrhage ( P = 0.0010). After covariates adjustment, current smokers with rs3918242-CT or TT genotype, compared to never-smokers with rs3918242-CC genotype, OR (95% CI) = 2.57 (1.74-3.46), have a higher subarachnoid hemorrhage risk. Our study showed that the rs3918242 (T) and rs17576 (G), the cross reaction between rs3918242 and smoking increased the risk of subarachnoid hemorrhage. Impact statement Matrix metalloproteinase-9 ( MMP-9) is a possible candidate gene for some diseases, including metabolic syndrome, stroke, coronary artery disease (CAD). But to date, limited data focused on the relationship between MMP-9 gene SNPs and SAH susceptibility. The purpose of this study was to evaluate SNPs of MMP-9 gene and their interaction with environmental factors with SAH risk based on a Chinese population.

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Matrix metalloproteinase-9 Gene-1562C>T Gene Polymorphism and Coronary Artery Disease in the Chinese Han Population: A Meta-Analysis of 5468 Subjects

Cited by 6 publications

References 27 publications

The association between Matrix Metallo-proteinases-9 (MMP-9) gene family polymorphisms and risk of Coronary Artery Disease (CAD): a systematic review and meta-analysis

The association between Matrix Metallo-proteinases-9 (MMP-9) gene family polymorphisms and risk of Coronary Artery Disease (CAD): a systematic review and meta-analysis

PCSK9 Gene E670G Polymorphism and Coronary Artery Disease: An Updated Meta-Analysis of 5,484 Subjects

Matrix metalloproteinase-9 gene polymorphisms and their interaction with environment on subarachnoid hemorrhage risk

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