Matrix metalloproteinase-9 contributes to human atrial remodeling during atrial fibrillation

Nakano, Yukiko; Niida, Shumpei; Dote, Keigo; Takenaka, Sou; Hirao, Hidekazu; Miura, Fumiharu; Ishida, Mari; Shingu, Tetsuji; Sueda, Taijiro; Yoshizumi, Masao; Chayama, Kazuaki

doi:10.1016/j.jacc.2003.08.060

Cited by 135 publications

(104 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was postulated that activation of different MMPs can modulate extracellular matrix collagen disintegration, which can in turn cause the structural and hence electrical remodelling of human atria. 3,4) It was also proven that Hcy can upregulate the activity of MMPs 2 and 9. 5,6) Another experimental study showed that Hcy could cause electro-physiological disturbances of potassium currents in human atrial myocytes.…”

Section: Discussionmentioning

confidence: 98%

“…1,2) It has been proven in previous studies that enhanced activity of matrix metalloproteinases (MMPs) may also be one of the mechanisms responsible for this. 3,4) It has been shown in animal studies that metalloproteinases in endocardial cells could be activated by homocysteine (Hcy). 5,6) Elevated levels of Hcy are associated with an increased risk of coronary artery disease and cerebrovascular disease.…”

mentioning

confidence: 99%

See 1 more Smart Citation

High Homocysteine Levels Predict the Recurrence of Atrial Fibrillation After Successful Electrical Cardioversion

et al. 2010

View full text Add to dashboard Cite

SummaryRecent data suggest that elevated plasma levels of homocysteine could be associated with atrial fibrillation (AF). The aim of our study was to investigate whether elevated plasma Hcy levels were predictive of the recurrence rate of AF after successful electrical cardioversion.Eighty-three patients (63 ± 12 years, 61.4% men) with persistent AF lasting at least 7 days were included after successful electrical cardioversion. Echocardiography and plasma homocysteine assay were performed prior to cardioversion and patient baseline characteristics were obtained. Patients were monitored for a period of 18 months.The patients were divided into two groups using a cut-off value for the last quartile of plasma homocysteine concentration (> 14.4 μmol/L). Kaplan Meier analysis showed a statistically significant difference in AF recurrence rates between both groups after 18 months (P = 0.02, log rank test). Cox proportional hazards multivariate analysis showed that predictors of AF recurrence were the duration of AF (OR 1.05, 95% CI 1.02-1.08, P = 0.00), treatment with amiodarone (OR 0.39, 95% CI 0.21-0.72, P = 0.00), and homocysteine level ≤ 14.4 μmol/L (OR 0.39, 95% CI 0.21-0.73, P = 0.00).We found that the homocysteine levels determined prior to electrical cardioversion can predict recurrence of AF after successful restoration of sinus rhythm. (Int Heart J 2010; 51: 30-33)

show abstract

Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

High Homocysteine Levels Predict the Recurrence of Atrial Fibrillation After Successful Electrical Cardioversion

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Remodeling of the atrial extracellular matrix, manifested by selective downregulation of TIMP2 expression and up-regulation of MMP2 expression, has been associated with the development of sustained AF (43). The markedly increased expression of MMP2 in the atria of patients with AF thus suggests the importance of this enzyme not only in extracellular matrix remodeling but also in the development of atrial dilation during progression of AF (43,44). In this study we showed that the -1306C➝T polymorphism of MMP2 is associated with AF, with the T allele representing a risk factor for this condition.…”

Section: Discussionmentioning

confidence: 99%

Genetic factors for lone atrial fibrillation

Kato

Oguri²,

Hibino³

et al. 2007

Int J Mol Med

View full text Add to dashboard Cite

Abstract. Atrial fibrillation (AF) may result from an electric conduction disturbance, increased hemodynamic stress, ischemia, inflammation, or remodeling in atria. Although genetic epidemiological studies have identified several genetic variants as risk factors for AF, the genetic determinants of this condition remain largely unknown. The purpose of the present study was to identify gene polymorphisms that confer susceptibility to lone AF. The study population comprised 1069 unrelated Japanese individuals, including 196 subjects with chronic lone AF and 873 controls. The genotypes for 40 polymorphisms of 32 candidate genes were determined by a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. Multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of smoking, hypertension, diabetes mellitus, and hypercholesterolemia as well as a stepwise forward selection procedure revealed that the -1306C➝T polymorphism of the matrix metalloproteinase 2 gene (MMP2) and the -592A➝C polymorphism of the interleukin 10 gene (IL10) were significantly (false discovery rate of <0.05) associated with the prevalence of AF. The T allele of the MMP2 polymorphism and the C allele of the IL10 polymorphism were a risk factor for and protective factor against AF, respectively. Determination of the genotypes for these polymorphisms may thus prove informative for assessment of the genetic component of AF.

show abstract

“…13,14,17- 21 We previously demonstrated that MMP-9 expression increases in fibrillating atrial tissue, which may contribute to the atrial structural remodeling of AF. 22 However, the mechanism of the increase in MMP-9 expression in fibrillating atrial tissue remains unknown.…”

Section: Ogi H Et Almentioning

confidence: 99%

Is Structural Remodeling of Fibrillated Atria the Consequence of Tissue Hypoxia?

Ogi

Nakano

Niida

et al. 2010

Circ J

Self Cite

View full text Add to dashboard Cite

Matrix metalloproteinase-9 contributes to human atrial remodeling during atrial fibrillation

Abstract: We clearly showed that the expression of the MMP-9 increased in fibrillating atrial tissue, which may have contributed to the atrial structural remodeling and atrial dilatation during AF.

Cited by 135 publications

References 38 publications

High Homocysteine Levels Predict the Recurrence of Atrial Fibrillation After Successful Electrical Cardioversion

High Homocysteine Levels Predict the Recurrence of Atrial Fibrillation After Successful Electrical Cardioversion

Genetic factors for lone atrial fibrillation

Is Structural Remodeling of Fibrillated Atria the Consequence of Tissue Hypoxia?

Contact Info

Product

Resources

About