Matrix metalloproteinase‐8 expression in periodontal tissues surgically removed from diabetic and non‐diabetic patients with periodontal disease

Hardy, D. C.; Ross, Jonathan H.; Schuyler, Corinne A.; Leite, Renata S.; Slate, Elizabeth H.; Huang, Yan

doi:10.1111/j.1600-051x.2011.01788.x

Cited by 23 publications

(26 citation statements)

References 38 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consistent with these findings, Hardy et al. reported significant differences in matrix metalloproteinase‐8 levels in periodontal tissue across their three study groups and a significant trend toward an increase in matrix metalloproteinase‐8 from patients without periodontitis or diabetes to patients with chronic periodontitis, to patients affected by both diseases.…”

Section: Changes In the Periodontal Tissuesmentioning

confidence: 58%

Local inflammatory reactions in patients with diabetes and periodontitis

Sonnenschein¹,

Meyle²

2015

Periodontology 2000

View full text Add to dashboard Cite

The impact of diabetes mellitus on the prevalence, severity and progression of periodontal disease has been known for many years and intense efforts have been made to elucidate the underlying mechanisms. It is widely reported that hyperglycemia causes numerous systemic changes, including altered innate immune‐cell function and metabolic changes. The aim of this review was to summarize and discuss the evidence for mechanisms that probably play a role in the altered local inflammatory reactions in the periodontium of patients with diabetes, focusing on local changes in cytokine levels, matrix metalloproteinases, reactive oxygen species, advanced glycation end‐products, immune‐cell functions, the RANKL/osteoprotegerin axis and toll‐like receptors. Apart from the systemic effects of diabetes, recent evidence suggests that local changes in the periodontal tissues are characterized by enhanced interactions between leukocytes and endothelial cells and by altered leukocyte functions [resulting in increased levels of reactive oxygen species and of proinflammatory cytokines (interleukin‐1β, interleukin‐6 and tumor necrosis factor‐α)]. These local changes are amplified by the enhanced accumulation of advanced glycation end‐products and their interaction with receptors for advanced glycation end‐products. Furthermore, the increased levels of proinflammatory cytokines lead to an up‐regulation of RANKL in periodontal tissues, stimulating further periodontal tissue breakdown.

show abstract

Section: Changes In the Periodontal Tissuesmentioning

confidence: 58%

Local inflammatory reactions in patients with diabetes and periodontitis

Sonnenschein¹,

Meyle²

2015

Periodontology 2000

View full text Add to dashboard Cite

show abstract

“…Increased MMP-8 levels in association with diabetes have earlier been shown in saliva, gingival crevicular fluid and in gingival tissues [29], [30], [31]. Increased concentrations of MMP-8 have been associated with an increased inflammatory process in patients with diabetes [32].…”

Section: Discussionmentioning

confidence: 90%

Salivary Biomarkers for Detection of Systemic Diseases

et al. 2013

View full text Add to dashboard Cite

Background and ObjectiveAnalysis of inflammatory biomarkers in saliva could offer an attractive opportunity for the diagnosis of different systemic conditions specifically in epidemiological surveys. The aim of this study was to investigate if certain salivary biomarkers could be used for detection of common systemic diseases.Materials and MethodsA randomly selected sample of 1000 adults living in Skåne, a county in the southern part of Sweden, was invited to participate in a clinical study of oral health. 451 individuals were enrolled in this investigation, 51% women. All participants were asked to fill out a questionnaire, history was taken, a clinical examination was made and stimulated saliva samples were collected. Salivary concentrations of IL-1β, -6, -8, TNF-α, lysozyme, MMP-8 and TIMP-1 were determined using ELISA, IFMA or Luminex assays.ResultsSalivary IL-8 concentration was found to be twice as high in subjects who had experience of tumour diseases. In addition, IL-8 levels were also elevated in patients with bowel disease. MMP-8 levels were elevated in saliva from patients after cardiac surgery or suffering from diabetes, and muscle and joint diseases. The levels of IL-1β, IL-8 and MMP-8, as well as the MMP-8/TIMP-1 ratio were higher in subjects with muscle and joint diseases.ConclusionBiomarkers in saliva have the potential to be used for screening purposes in epidemiological studies. The relatively unspecific inflammatory markers used in this study can not be used for diagnosis of specific diseases but can be seen as markers for increased systemic inflammation.

show abstract

“…Periodontal disease develops as a result of disturbances in the oral microbiota, leading to an immune response of the host, thus affecting periodontium protection and support . Systemic diseases and environmental and psychological factors are considered as periodontal disease modulators …”

Section: Introductionmentioning

confidence: 99%

Matrix metalloproteinase‐8 levels in periodontal disease patients: A systematic review

Morais

Pinheiro

Leite

et al. 2017

J of Periodontal Research

View full text Add to dashboard Cite

Periodontal disease is characterized as a disorder of the oral microbiota resulting in an immune response which, in turn, leads to the destruction of periodontal tissue. Matrix metalloproteinase-8 (MMP-8) has been reported as the major metalloproteinase involved in periodontal disease, being present at high levels in gingival crevicular fluid and salivary fluid (SF). The aim of this systematic review was to evaluate the scientific literature regarding the expression of MMP-8 in gingival crevicular fluid and SF in patients with periodontal disease, analyzing its validity as a possible biomarker in the diagnosis of periodontal disease. A systematic review of the literature was performed using the PubMed/Medline, CENTRAL and Science Direct databases. Studies concerning the use of MMP-8 in the diagnosis of periodontal disease that evaluated its effectiveness as a biomarker for periodontal disease were selected. The search strategy provided a total of 6483 studies. After selection, six articles met all the inclusion criteria and were included in the present systematic review. The studies demonstrated significantly higher concentrations of MMP-8 in patients with periodontal disease compared with controls, as well as in patients presenting more advanced stages of periodontal disease. The findings on higher MMP-8 concentrations in patients with periodontal disease compared with controls imply the potential adjunctive use of MMP-8 in the diagnosis of periodontal disease.

show abstract

Matrix metalloproteinase‐8 expression in periodontal tissues surgically removed from diabetic and non‐diabetic patients with periodontal disease

Cited by 23 publications

References 38 publications

Local inflammatory reactions in patients with diabetes and periodontitis

Local inflammatory reactions in patients with diabetes and periodontitis

Salivary Biomarkers for Detection of Systemic Diseases

Matrix metalloproteinase‐8 levels in periodontal disease patients: A systematic review

Contact Info

Product

Resources

About