Matrix Metalloproteinase-2 Promoter Polymorphism Is Associated with Breast Cancer in a Mexican Population

Delgado‐Enciso, Iván; Cepeda-López, Friedman Rafael; Monrroy-Guizar, Elisa A.; Bautista-Lam, Jose R.; Andrade-Soto, Maricela; Jonguitud-Olguin, Gregorio; Rodríguez-Hernández, Alejandrina; Anaya-Ventura, Aristoteles; Baltazar-Rodríguez, Luz M.; Orozco-Ruiz, Martha; Soriano-Hernández, Alejandro D.; Rodríguez‐Sánchez, Iram P.; Lugo‐Trampe, Ángel; Espinoza-Gomez, Francisco; Michel-Peregrina, Martha L.

doi:10.1159/000108282

Cited by 48 publications

(39 citation statements)

References 40 publications

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“…The genotype variants were analyzed using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) methodology for all the SNPs. Primer sequences, PCR conditions and the restriction enzymes used have been described elsewhere for both MMP2 and TIMP2 [12][13][14][15]. Positive and negative controls were used in each genotyping assay, and 5 % of the samples were randomly selected and run in duplicates with 100 % concordance.…”

Section: Mmp-2 (-735c [ T) [Rs 2285053] and Timp-2 (-418g [ C) [Rs 81mentioning

confidence: 99%

No Association of Matrix Metalloproteinase [MMP]-2 (−735C > T) and Tissue Inhibitor of Metalloproteinase [TIMP]-2 (−418G > C) Gene Polymorphisms with Cervical Cancer Susceptibility

et al. 2012

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Genomic DNA extraction from peripheral blood samples, collected from the study subjects, was carried out using salting-out method. MMP-2 and TIMP-2 genotyping was performed using polymerase chain reaction-based restriction fragment length polymorphism. Our findings demonstrated no significant association between MMP-2 (-735C [ T) and TIMP-2 (-418G [ C) gene polymorphisms and the risk of developing cervical cancer in the study population. Further stratified analysis using a caseonly study approach revealed that there was no effect of MMP-2/TIMP-2 polymorphisms on early and advanced stages of cervical cancer. Further MMP-2 and TIMP-2 polymorphisms did not modulate the risk in cervical cancer patients who smoked tobacco/cigarettes. Overall, the present study demonstrated a lack of association between MMP-2 and TIMP-2 gene polymorphisms and cervical cancer susceptibility in women of Northern India.

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Section: Mmp-2 (-735c [ T) [Rs 2285053] and Timp-2 (-418g [ C) [Rs 81mentioning

confidence: 99%

No Association of Matrix Metalloproteinase [MMP]-2 (−735C > T) and Tissue Inhibitor of Metalloproteinase [TIMP]-2 (−418G > C) Gene Polymorphisms with Cervical Cancer Susceptibility

et al. 2012

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“…The DNA was resuspended in 100 ll water and stored at -20°C until analyzed. Polymerase chain reactions (PCR) for the MMP-2 gene promoter polymorphic region were carried out in a total volume of 25 ll, as previously described (Delgado-Enciso et al 2008). The solution contained 50 ng genomic DNA, 0.1 lM each primer, 1 9 Taq polymerase buffer (1.4 mM MgCl 2 ), 0.2 mM dNTP, and 0.25 U AmpliTaq DNA polymerase (Perkin Elmer, Foster City, CA).…”

Section: Polymorphism Analysismentioning

confidence: 99%

Polymorphism in the Matrix Metalloproteinase-2 Gene Promoter is Associated with Cervical Neoplasm Risk in Mexican Women

et al. 2008

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Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity on matrix proteins, and previous studies have revealed a strong association between the MMP-2 -1306C-->T polymorphism and the risk of several types of cancer. Our study looked at whether this polymorphism contributed to the development of cervical neoplasia by analyzing 54 patients with invasive squamous cell cervical cancer, 100 patients with cervical intraepithelial neoplasia, and 126 control subjects. The MMP-2 CC genotype was more frequent in the cancer patients when compared with the control group (OR 2.57; 95% CI 1.15-5.86). The association of cervical cancer with the CC genotype was more pronounced in women who had first coitus at an early age (OR 3.96; 95% CI 1.46-11.06). The CC genotype was associated with intraepithelial neoplasia only in women with first coitus at 19 years old or younger. The data suggest that the MMP-2 -1306C-->T polymorphism contributes to the development of squamous cell cervical cancer in the population studied, especially in women who had first coitus at an early age.

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“…It represents 16% of all cancers in women [2]. The risk for the development of breast cancer is the result of a combination of hereditary and environmental factors, the latter of which include aspects of lifestyle and diet [3,4,5]. The consumption of certain foods may modify the risk for the development of cancer.…”

Section: Introductionmentioning

confidence: 99%

The Protective Effect of Peanut, Walnut, and Almond Consumption on the Development of Breast Cancer

Soriano-Hernández

Madrigal-Pérez

Galvan-Salazar

et al. 2015

Gynecol Obstet Invest

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Background/Aims: Breast cancer is the most common gynecologic malignancy known worldwide. The consumption of certain foods may modify the risk for its development. Peanuts and other seeds have shown anticarcinogenic effects in vitro, but there are a few studies that evaluate the effect of their consumption on the development of breast cancer. The aim of the present study was to determine whether there is an association between the consumption of peanuts, walnuts, and almonds and the development of breast cancer. Methods: We analyzed 97 patients presenting with breast cancer and 104 control subjects that did not have the pathology (BIRADS 1-2). An analysis of the main clinical characteristics and lifelong seed consumption was carried out. The association between the consumption of these foods and the risk for breast cancer was estimated by odds ratios and 95% confidence intervals, controlling other risk factors, using the Mantel-Haenszel analysis. Results: The high consumption of peanuts, walnuts, or almonds significantly reduced the risk for breast cancer by 2-3 times. This protective effect was not found with low or moderate seed consumption when compared with null consumption. Conclusions: High consumption of peanuts, walnuts, and almonds appears to be a protective factor for the development of breast cancer.

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Matrix Metalloproteinase-2 Promoter Polymorphism Is Associated with Breast Cancer in a Mexican Population

Cited by 48 publications

References 40 publications

No Association of Matrix Metalloproteinase [MMP]-2 (−735C > T) and Tissue Inhibitor of Metalloproteinase [TIMP]-2 (−418G > C) Gene Polymorphisms with Cervical Cancer Susceptibility

No Association of Matrix Metalloproteinase [MMP]-2 (−735C > T) and Tissue Inhibitor of Metalloproteinase [TIMP]-2 (−418G > C) Gene Polymorphisms with Cervical Cancer Susceptibility

Polymorphism in the Matrix Metalloproteinase-2 Gene Promoter is Associated with Cervical Neoplasm Risk in Mexican Women

The Protective Effect of Peanut, Walnut, and Almond Consumption on the Development of Breast Cancer

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