Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endometrium

Chung, Hye Won; Lee, Ji Young; Moon, Hye Sung; Hur, Sung Eun; Park, Mi Hye; Wen, Yan; Polan, Mary Lake

doi:10.1016/s0015-0282(02)03322-8

Cited by 163 publications

(127 citation statements)

References 29 publications

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“…For RT-PCR, the Gen Amp RNA PCR kit (Perkin-Elmer, Foster City, CA, USA) was used. Nineteen microliters of RT-mastermix for each sample were prepared containing 5 mmol/L MgCl 2 , 1X PCR buffer II, 1 mmol/L of each deoxy-NTP, 2.5 μL/L oligo (deoxythimidine) 16 , 20 IU ribonuclease inhibitor (all from Perkin-Elmer), 100 IU Moloney murine leukemia virus reverse transcriptase (Gibco BRL), and 1 μg total RNA diluted in 1 μL DEPC-treated H 2 O and placed into 0.2 mL thin wall PCR tube (Applied Scientifi c, South San Francisco, CA, USA). RT was carried out in the DNA Thermal Cycler 9600 (Perkin-Elmer) using a program with the following parameters: 42°C, 15 min; 99°C, 5 min; then quenched at 4°C.…”

Section: Rna Extractionmentioning

confidence: 99%

“…Previous reports showed that MT-MMPs play an important role in angiogenesis [10,12,13], especially MT1-MMP has received considerable attention as being involved in tumor angiogenesis [14,15]. Several MTMMPs have been demonstrated in whole endometrial extracts at mRNA level [16,17], and MT1-and MT2-MMP antigens have been demonstrated in various endometrial cell types [18,19]. MT-MMPs act at the cell surface where they can locally facilitate degradation of extracellular matrix, cell migration, invasion and angiogenesis.…”

mentioning

confidence: 99%

“…The abundance of all MT-MMP in cycling endometrium suggests that endometrial MT-MMPs play a role in remodeling of cycling endometrium in preparation for implantation [20]. MT-MMPs are inhibited by tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) [16]. The endometriosis-associated increase in proteolysis and imbalance between the secretion of MMP-9 and that of its natural inhibitor, TIMP-1, revealed in the culture medium of endometrial tissue [21].…”

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confidence: 99%

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Expression ofmembrane type-2and-3 matrix metalloproteinasesin eutopic endometrium of women with advanced endometriosis

Chung

Lee

Jeong

et al. 2011

Korean J Obstet Gynecol

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Section: Rna Extractionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Expression ofmembrane type-2and-3 matrix metalloproteinasesin eutopic endometrium of women with advanced endometriosis

Chung

Lee

Jeong

et al. 2011

Korean J Obstet Gynecol

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“…In a study, it was suggested that altered PRL secretion and decreased serum estradiol after thyrotrophinreleasing hormone administration in infertile women with endometriosis was strongly related to a dysfunction of the hypothalamic-hypophyseal-ovarian axis and could be the cause of infertility in these patients [90]. Matrix metalloproteinase-2 (MMP-2) has emerged as one of the key participants in the adhesion and proliferation of shed menstrual tissue in the pathogenesis of endometriosis [91]. Estradiol has been shown to up-regulate the MMP-2 action leading to formation of endometriosis, and progesterone has been associated with down-regulation of MMP-2 action inhibiting the development of endometriosis [92].…”

Section: Endometriosis and Immune-endocrine Interactionmentioning

confidence: 99%

Laparoscopic surgery for endometriosis-associated infertility: a pathophysiologic approach

Pahlajani

Falcone

2010

Gynecol Surg

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Endometriosis has been one of the most confusing gynecological diseases since it was first described. Whereas there is a reasonable body of evidence in literature to demonstrate an association between endometriosis and infertility, a definite cause and effect relationship has not been established. The mechanism by which endometriosis causes infertility remains an enigma. Virtually every aspect of reproduction in women with endometriosis has been investigated and purported to be impaired. Impairment of implantation and pregnancy rates seems to affect women with endometriosis. Whether this is due to poor quality embryos derived from impaired oocytes or endometrial defects or both has been argued. Structural abnormalities of the uterine wall and tube in women with endometriosis have also been described by other researchers. Adding more confusion to this topic is the altered immune function and the peritoneal environment and their detrimental effects on the sperm motility and morphology. This uncertain pathophysiology has resulted in the lack of consensus on the treatment of endometriosis-associated infertility. The aim of this review is to describe the current pathophysiology of endometriosis-related infertility, how laparoscopic surgery may influence fertility rates.

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“…Les MMPs interviennent également au niveau de l'angiogenèse, car elles permettent la protéolyse de la membrane basale sous-endothéliale et la migration des cellules endothéliales à travers la matrice extracellulaire. La détection des MMP-2 et MMP-9, au niveau des lésions d'endométriose, confirme cette hypothèse [29]. Des données impliquent une corrélation entre la surexpression de MMPs et la sous-expression de leurs inhibiteurs (TIMPs) d'une part, et l'importance de la vascularisation de la lésion d'autre part [30].…”

Section: Angiogenèseunclassified

Pathogenèse de l'endométriose

Nisolle

Álvarez

Colombo

et al. 2007

Gynécologie Obstétrique & Fertilité

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RésuméL'endométriose, définie par la présence ectopique de tissu endométrial, est une affection bénigne responsable d'infertilité ou de douleurs pelviennes. Un diagnostic précoce fondé sur une anamnèse minutieuse et un examen clinique bien conduit permet une prise en charge précoce. Le traitement médical n'est pas approprié dans tous les cas, faisant place à la coelioscopie opératoire dont la morbidité est en relation avec la sévérité de la lésion. L'implantation ectopique de cellules endométriales est possible grâce à des interactions complexes entre le tissu hôte et les cellules épithéliales endométriales. Les conditions nécessaires au développement de l'endométriose sont une prolifération estrogénodépendante des cellules endométriales, une induction d'angiogenèse et d'une lymphangiogenèse. Les principaux acteurs cellulaires et moléculaires de l'angiogenèse, de la lymphangiogenèse et de la fibrose doivent être identifiés afin de permettre le développement de nouvelles stratégies thérapeutiques de l'endométriose. Mots clés :Endométriose ; Angiogenèse ; Lymphangiogenèse ; Inflammation ; Fibrose Abstract Endometriosis, defined by the development of endometrial tisue outside the uterus, is a benign disease responsible for infertility and pelvic pain. The diagnosis based on a detailed gynecological history and a careful clinical examination should be done as early as possible in order to treat patients correctly. Medical treatment is not appropriate in all cases and surgical treatment should be proposed but morbidity is related to the severity of the lesion. Ectopic implantation of endometrial cells needs complex interactions between host tissue and epithelial endometrial cells. The conditions for the development of endometriosis are estrogeno-dependent growth of endometrial cells, induction of angiogenesis and lymphangiogenesis. Principal cellular and molecular factors of angiogenesis, lymphangiogenesis and fibrosis should be identified in order to develop new therapeutic strategies of endometriosis.

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Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endometrium

Cited by 163 publications

References 29 publications

Expression ofmembrane type-2and-3 matrix metalloproteinasesin eutopic endometrium of women with advanced endometriosis

Expression ofmembrane type-2and-3 matrix metalloproteinasesin eutopic endometrium of women with advanced endometriosis

Laparoscopic surgery for endometriosis-associated infertility: a pathophysiologic approach

Pathogenèse de l'endométriose

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