Matrix metalloproteinase-2 gene polymorphisms are associated with ischemic stroke in a Hainan population

Niu, Fanglin; Wei, Boping; Yan, Mengdan; Li, Jing; Ouyang, Yongri; Jin, Tianbo

doi:10.1097/md.0000000000012302

Cited by 10 publications

(15 citation statements)

References 34 publications

(32 reference statements)

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“…Manso et al 23 reported that MMP2 gene polymorphisms are associated with the outcome of ischemic stroke after 3 months; however, other studies have failed to show a significant association between MMP2 1306C/T and 735C/T sites and carotid intima-media thickness. 24 Liu et al demonstrated that the 735C/T polymorphism of MMP2 is associated with ischemic stroke in a Chinese population. 25 Additionally, Xu et al reported that the 1306C/T polymorphism of MMP2 is associated with atherosclerotic cerebral infarction.…”

Section: Discussionmentioning

confidence: 99%

Correlation between matrix metalloproteinase-2 polymorphisms and first and recurrent atherosclerotic ischemic stroke events: a case–control study

Liu

Ouyang

et al. 2021

J Int Med Res

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Objective To determine the associations between matrix metalloproteinase-2 (MMP-2, encoded by the MMP2 gene) 1306C/T and 735C/T polymorphisms and first and recurrent ischemic stroke in a Chinese population. Methods Patients with first and recurrent ischemic stroke were included. Serum MMP-2 was measured, and MMP2 1306C/T and 735C/T polymorphisms were detected. The associations between MMP2 1306C/T and 735C/T polymorphisms and first and recurrent ischemic stroke were analyzed. Results Serum MMP-2 in patients with first and recurrent ischemic stroke was significantly higher compared with controls, and patients with recurrent ischemic stroke had higher MMP-2 than those with first ischemic stroke. The frequency of the CC genotype and C allele of MMP2 735C/T was highest in patients with recurrent ischemic stroke, followed by patients with first ischemic stroke, and controls. Conversely, the genotype and allele of MMP2 1306C/T did not significantly differ between groups. The CC genotype of MMP2 735C/T was independently associated with first and recurrent ischemic stroke (odds ratios = 1.45 and 1.64, respectively), as was the C allele of MMP2 735C/T (odds ratios = 1.68 and 1.77, respectively). Conclusions The CC genotype and C allele of MMP2 735C/T were associated with first and recurrent ischemic stroke in a Chinese population.

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Section: Discussionmentioning

confidence: 99%

Correlation between matrix metalloproteinase-2 polymorphisms and first and recurrent atherosclerotic ischemic stroke events: a case–control study

Liu

Ouyang

et al. 2021

J Int Med Res

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“…The effects of MMP gene variations in various diseases with acute brain damage have been investigated. A significant relationship was found between the genetic variations identified in MMP genes and changes in MMP enzyme expression levels [7,17]. MMPs have been associated with various physiological and pathological processes.…”

Section: Discussionmentioning

confidence: 99%

“…Chronic inflammation promotes atherosclerotic plaque formation and plaque rupture, and thus can lead to the development of ischemic stroke (6). Clinical, environmental, and demographic risk factors have been associated with the development and pathogenesis of ischemic stroke [7]. In addition, ischemic stroke is accepted as a multifactorial disease in which genetic and environmental factors play together a role in its pathogenesis [5,6].…”

Section: Introductionmentioning

confidence: 99%

Determination of the role of Matrix Metalloproteinase-1 (-1607 1G/2G) gene variation in ischemic stroke development

Alkanlı¹

2021

Erciyes Med J

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Objective: Matrix Metalloproteinase (MMP) family is one of the potential genetic risk factors for the development of cerebrovascular disease such as ischemic stroke. Excessive MMP-1 protein production occurs and MMP-1 enzyme activity increases as a result of MMP-1 (-1607 1G/2G) gene variation. Thus, the sensitivity to ischemic stroke can be modulated. Therefore, the purpose of our study is to investigate the effect of MMP-1 (-1607 1G/2G) gene variation in development of ischemic stroke disease in the Thrace population of Turkey. Methods:Our study was performed with 87 ischemic stroke patients and 80 healthy controls.Polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLP) methods were used to determine genotype distributions of MMP-1 (-1607 1G/2G) gene variations.Results: In patient group, 1G/1G genotype (56.9%) and 1G/2G genotypes (55.1%) of MMP-1 (-1607 1G/2G) gene variation were observed higher compared to control group. However the significant difference was not determined between ischemic stroke patient and healthy control groups in terms of MMP-1 (-1607 1G/2G) gene variation genotype distributions (p=0.127, ns).Allele frequencies of MMP-1 (-1607 1G/2G) gene variation in ischemic stroke patient and healthy control groups were not found significantly different from the Hardy-Weinberg distribution (p= 0.6556, ns and p= 0.0501, ns respectively). Conclusion:1G/1G and 1G/2G genotypes of MMP-1 (-1607 1G/2G) gene variation were observed higher in ischemic stroke group compared to healthy control group. However, MMP-1 (-1607 1G/2G) gene variation was not determined as a genetic risk factor for development of ischemic stroke in Thrace population of Turkey.

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“…more specifically, ectopic vascular calcification has become an important topic in public health and over the last years, several studies have shown the important involvement of MMPs and TIMPs in cardiovascular diseases, including coronary artery disease, 107 myocardial infarction, 108 atherosclerosis, 109 and ischemic stroke. 110,111 In cardiovascular diseases, MMPs act in the weakening of vessels since they are able to degrade all their major components, essential for the maintenance of vascular tonus. 112 The main MMPs involved in cardiovascular diseases are MMP-2 and MMP-9.…”

Section: Mmps and Ectopic Vascular Calcificationmentioning

confidence: 99%

Updating the role of matrix metalloproteinases in mineralized tissue and related diseases

et al. 2019

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Updating the role of matrix metalloproteinases in mineralized tissue and related diseases Bone development and healing processes involve a complex cascade of biological events requiring well-orchestrated synergism with bone cells, growth factors, and other trophic signaling molecules and cellular structures. Beyond health processes, MMPs play several key roles in the installation of heart and blood vessel related diseases and cancer, ranging from accelerating metastatic cells to ectopic vascular mineralization by smooth muscle cells in complementary manner. The tissue inhibitors of MMPs (TIMPs) have an important role in controlling proteolysis. Paired with the post-transcriptional efficiency of specific miRNAs, they modulate MMP performance. If druggable, these molecules are suggested to be a platform for development of "smart" medications and further clinical trials. Thus, considering the pleiotropic effect of MMPs on mammals, the purpose of this review is to update the role of those multifaceted proteases in mineralized tissues in health, such as bone, and pathophysiological disorders, such as ectopic vascular calcification and cancer. Bone is a specialized, vascular, and dynamic connective tissue in constant remodeling to maintain physiological ion homeostasis, give support and protection for soft tissue, and be a reservoir of ions important to vertebrates. 1-3 Mechanistically, bone remodeling requires a coordinate and dynamic relationship between deposition/degradation of extracellular matrix (ECM), through growth factors and other signaling molecules, which results in ECM remodeling-an important prerequisite for cell adhesion, migration, proliferation, differentiation. 4 It is well known that osteoclasts resorb the mineralized matrix and further promote the remodeling of the organic fraction of the bone, while, conversely, osteoblasts are responsible for bone formation by depositing specialized ECM components prior to mineralizing it properly 2 . The balance between those specialized cells is crucial for maintaining appropriate bone mass, and the lack of this synchronism contributes to the occurrence of bone diseases, such as osteoporosis and Paget's. To date, ultimate bone cellular differentiation is known to depend on wellorchestrated communication between formation and resorption events. 2,5-7 More specifically, during bone repair after trauma, bone healing depends on interactions between specific signaling inflammatory cytokines and non-resident and eventual cells (such as polymorphonuclear leukocytes and monocyte-macrophage lineage), 8 requiring ECM remodeling by specific matrix metalloproteinases (MMPs). Generally, MMPs are an important family of zinc-dependent endopeptidases and are the major class of enzymes responsible for the degradation or resorption of all ECM components (Figure 1). 9-15 MMP targets include other proteases, protease inhibitors, blood coagulation factors, chemotactic molecules, latent growth factors, binding protein growth factor, cell surface receptors, and cell adhesion molecule...

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Matrix metalloproteinase-2 gene polymorphisms are associated with ischemic stroke in a Hainan population

Cited by 10 publications

References 34 publications

Correlation between matrix metalloproteinase-2 polymorphisms and first and recurrent atherosclerotic ischemic stroke events: a case–control study

Correlation between matrix metalloproteinase-2 polymorphisms and first and recurrent atherosclerotic ischemic stroke events: a case–control study

Determination of the role of Matrix Metalloproteinase-1 (-1607 1G/2G) gene variation in ischemic stroke development

Updating the role of matrix metalloproteinases in mineralized tissue and related diseases

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