Matrix Metalloproteinase-2 Cleavage of the β1 Integrin Ectodomain Facilitates Colon Cancer Cell Motility

Kryczka, Jakub; Stasiak, Marta; Dziki, Łukasz; Mik, Michał; Dziki, Adam; Cierniewski, Czesław S.

doi:10.1074/jbc.m112.384909

Cited by 66 publications

(54 citation statements)

References 37 publications

(32 reference statements)

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“…These multi-functional degrading enzymes play a critical role in carcinogenesis but also in other stages of the invasion-metastasis cascade. CRC cells may induce the expression of MMP-2 and -9 by stromal cells, either directly or via a paracrine mechanism, thus modifying ECM and promoting tumour development [56][57][58] .…”

Section: Lymphocytesmentioning

confidence: 99%

Natural history of hepatic metastases from colorectal cancer - pathobiological pathways with clinical significance

Paschos

Majeed

Bird

2014

WJG

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Colorectal cancer hepatic metastases represent the final stage of a multi-step biological process. This process starts with a series of mutations in colonic epithelial cells, continues with their detachment from the large intestine, dissemination through the blood and/or lymphatic circulation, attachment to the hepatic sinusoids and interactions with the sinusoidal cells, such as sinusoidal endothelial cells, Kupffer cells, stellate cells and pit cells. The metastatic sequence terminates with colorectal cancer cell invasion, adaptation and colonisation of the hepatic parenchyma. All these events, termed the colorectal cancer invasion-metastasis cascade, include multiple molecular pathways, intercellular interactions and expression of a plethora of chemokines and growth factors, and adhesion molecules, such as the selectins, the integrins or the cadherins, as well as enzymes including matrix metalloproteinases. This review aims to present recent advances that provide insights into these cell-biological events and emphasizes those that may be amenable to therapeutic targeting. Paschos KA, Majeed AW, Bird NC. Natural history of hepatic metastases from colorectal cancer -pathobiological pathways with clinical significance.

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Section: Lymphocytesmentioning

confidence: 99%

Natural history of hepatic metastases from colorectal cancer - pathobiological pathways with clinical significance

Paschos

Majeed

Bird

2014

WJG

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“…It was reported that the critical step for invasion and metastasis is the breakdown of the basement membrane, which involved the activation of proteolytic enzymes such as MMPs. MMPs play an important role in tumor angiogenesis, metastasis and stimulation of growth factor release from the ECM (Kryczka et al, 2012). Numerous studies indicate that inhibition of MMP expression or enzyme activity can be used as early targets for preventing cancer metastasis (Zucker & Vacirca, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Matrix metalloproteinases (MMPs), a family of human zinc-dependent endopeptidases, degrade the ECM (Junttila et al, 2007;Liang, 2011). Among them, the gelatinases (MMP-2 and MMP-9) efficiently degrade native collagen types IV and V, fibronectin and elastin (Kryczka et al, 2012). MMP-9 activity can be stimulated by various growth factors and proinflammatory cytokines and agents, including phorbol 12-myristate 13-acetate (PMA) (Woo, Park, Choi, Kim, & Kim, 2008).…”

Section: Introductionmentioning

confidence: 99%

Phellinus linteus grown on germinated brown rice Suppress metastasis and Induce Apoptosis of Colon Cancer Cells by suppressing NF-κB and Wnt/β-catenin Signaling Pathways

Park

2015

Journal of Functional Foods

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“…MMP-2 was shown to be an important factor associated with the development and metastasis of gastric and colorectal cancer and may be used as a prognostic marker (108,109).…”

Section: Matrix Metalloproteinases (Mmps)mentioning

confidence: 99%

Research and clinical applications of molecular biomarkers in gastrointestinal carcinoma (Review)

2013

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Gastrointestinal (GI) carcinoma is a common malignant disease worldwide. Its development and progression is a multistage process involving a multifactorial etiology. Although the detailed mechanisms of the development of GI carcinoma remain controversial, the elucidation of its molecular biology over the last few years has resulted in a better perspective on its epidemiology, carcinogenesis and pathogenesis. More significantly, it is currently possible to use biological indicators or biomarkers in differential diagnosis, prognostic evaluation and specific clinical interventions. In this review, we aimed to describe the biomarkers of pathogenesis, invasion, metastasis and prognosis of GI carcinoma and discuss their potential clinical applications. The majority of these biomarkers, such as tumor-associated antigens, oncogenes and tumor suppressor genes, metastasis-associated genes, cell adhesion molecules, cytokines, growth factors and microRNAs, are currently broadly applicable.

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Matrix Metalloproteinase-2 Cleavage of the β1 Integrin Ectodomain Facilitates Colon Cancer Cell Motility

Cited by 66 publications

References 37 publications

Natural history of hepatic metastases from colorectal cancer - pathobiological pathways with clinical significance

Natural history of hepatic metastases from colorectal cancer - pathobiological pathways with clinical significance

Phellinus linteus grown on germinated brown rice Suppress metastasis and Induce Apoptosis of Colon Cancer Cells by suppressing NF-κB and Wnt/β-catenin Signaling Pathways

Research and clinical applications of molecular biomarkers in gastrointestinal carcinoma (Review)

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