Matrix metalloproteinase-10 and microvascular complications of type 1 diabetes: might vitamin D status be relevant?

Boucher, Barbara J

doi:10.1007/s00125-014-3189-9

Cited by 5 publications

(4 citation statements)

References 7 publications

(7 reference statements)

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“…In addition, although in chronic human hypertension elevated activity of MMP-3 has been reported (45), MMP-10 experimentally has been shown to regulate tumor cell migration, invasion and EC tube formation (46). In a recent report, Toni et al documented that increased circulating MMP-10 was associated with increased microvascular disease risks including diabetic retinopathy in type 1 diabetes (47). In addition, MMP-10 has been reported to play a critical role in muscle regeneration during injury and muscular dystrophy (48).…”

Section: Types Of Mmps and Their Involvement In Diseasesmentioning

confidence: 99%

Regulation and involvement of matrix metalloproteinases in vascular diseases

et al. 2016

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Matrix metalloproteinases (MMPs) are a family of zinc dependent endopeptidases whose main function is to degrade and deposit structural proteins within the extracellular matrix (ECM). A dysregulation of MMPs is linked to vascular diseases. MMPs are classified into collagenases, gelatinases, membrane-type, metalloelastase, stromelysins, matrilysins, enamelysins, and unclassified subgroups. The production of MMPs is stimulated by factors such as oxidative stress, growth factors and inflammation which lead to its up- or down-regulation with subsequent ECM remodeling. Normally, excess activation of MMPs is controlled by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). An imbalance of MMPs and TIMPs has been implicated in hypertension, atherosclerotic plaque formation and instability, aortic aneurysms and varicose vein wall remodeling. Also, recent evidence suggests epigenetic regulation of some MMPs in angiogenesis and atherosclerosis. Over the years, pharmacological inhibitors of MMPs have been used to modify or prevent the development of the disease with some success. In this review, we discuss recent advances in MMP biology, and their involvement in the manifestation of vascular disease.

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Section: Types Of Mmps and Their Involvement In Diseasesmentioning

confidence: 99%

Regulation and involvement of matrix metalloproteinases in vascular diseases

et al. 2016

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“…MMP10 has been associated with inflammatory pathology, wound healing, and vascular remodelling [ 13 , 14 , 15 , 16 , 17 ]. In ocular vascular pathology, elevated vitreous concentrations of MMP10 have been described in patients with venous occlusions with ischaemic manifestations [ 18 ], and the plasma levels correlate with vascular complications in patients with diabetic retinopathy [ 16 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Matrix Metalloproteinase 10 Contributes to Choroidal Neovascularisation

et al. 2022

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Age-related macular degeneration (AMD) is currently the main cause of severe visual loss among older adults in developed countries. The pathophysiology has not been clarified, but oxidative stress is believed to play a major role. Matrix metalloproteinases (MMP) may play a prominent role in several steps of the pathophysiology of AMD, especially in its neovascular form; therefore, there is of great interest in understanding their role in choroidal neovascularisation. This study aimed to elucidate the role of MMP10 in the development of choroidal neovascularisation (CNV). We have demonstrated that MMP10 was expressed by retinal pigment epithelium cells and endothelial cells of the neovascular membrane, in cell culture, mouse and human retina. MMP10 expression and activity increased under oxidative stress conditions in ARPE-19 cells. MMP10-/- mice developed smaller laser-induced areas of CNV. Furthermore, to exclude a systemic MMP10 imbalance in these patients, plasma MMP10 concentrations were assessed in an age- and sex-matched sample of 52 control patients and 52 patients with neovascular AMD and no significant differences were found between the groups, demonstrating that MMP10 induction is a local phenomenon. Our findings suggest that MMP10 participates in the development of choroidal neovascularisation and promotes MMP10 as a possible new therapeutic target.

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“…In addition, MMP‐10 may be closely related to inflammation, immunity and tumor progression . Clinical findings have suggested that abnormal expression of MMP‐10 may be involved in the pathophysiological process of various diseases, such as ischemic stroke, head and neck squamous cell carcinoma (HNSCC), and diabetes . Moreover, previous studies have shown that genetic polymorphisms in the MMP‐10 gene may affect the expression levels of MMP‐10 , which may be implicated in the development of diseases .…”

Section: Introductionmentioning

confidence: 99%