Matrix metalloproteinase-1 expression in breast cancer and cancer-adjacent tissues by immunohistochemical staining

Abstract

Abstract. Although matrix metalloproteinase-1 (MMP-1) has been considered a factor of crucial importance for breast cancer cells invasion and metastasis, the expression of MMP-1 in different breast cancer and cancer-adjacent tissues have not been fully examined. In the present study, immunohistochemical staining was used to detect the MMP-1 expression in non-specific invasive ductal carcinoma of the breast, cancer-adjacent normal breast tissue, lymph node metastatic non-specific invasive ductal carcinoma of the breast and normal lymph node tissue. The results showed that MMP-1 expression is different in the above tissues. MMP-1 had a positive expression in normal lymph node tissue and lymph node metastatic non-specific invasive ductal carcinoma. The MMP-1 negative expression rate was only 6.1% in non-specific invasive ductal carcinoma of the breast and 2.9% in cancer-adjacent normal breast tissue respectively. MMP-1 expression is higher in non-specific invasive ductal carcinoma and lymph node metastatic non-specific invasive ductal carcinoma compared to cancer-adjacent normal breast tissue and normal lymph node tissue. In conclusion, higher expression of MMP-1 in breast cancer may play a crucial role in promoting breast cancer metastasis.

Biological significance of genome‐wide DNA methylation profiles in keloids

“…MMPs are a family of proteases whose function includes the degradation of extracellular matrix. MMP regulation has been implicated in keloid pathogenesis because of a lack of extracellular matrix degradation and has been associated with metastasis due to degradation of the basement membrane . Alterations of ACTR3C and the PLC pathway could be part of a common genetic profile that allows for tumorigenesis but stops short of transformation to malignancy in keloids.…”

IBI: Identification of Biomarker Genes in Individual Tumor Samples

“…Furthermore, OS and disease-free survival in the low CST1 expression subgroup were significantly superior to those in the high CST1 expression subgroup, indicating that CST1 could be a prognostic indicator and a potential therapeutic target for breast cancer (Dai et al, 2017). Xuan et al (2015) reported that higher expression of MMP1 in breast cancer might play a crucial part in promoting breast cancer metastasis. Powell et al (2018) demonstrated that CEACAM5 was a clinically relevant driver of breast cancer metastasis.…”

dBMHCC: A comprehensive hepatocellular carcinoma (HCC) biomarker database provides a reliable prediction system for novel HCC phosphorylated biomarkers

“…another novel HCC-related gene. MMP1 is involved in the breakdown of extracellular matrix during normal and disease processes, and has been identified as a crucial factor for invasion and metastasis in bladder cancer, stomach cancer, breast cancer, and esophageal squamous cell carcinoma [30][31][32][33]. According to these results, the top three predicted HCC markers are involved in HCC, and the following six predicted markers are involved in other cancers.…”