Matrix Effectors and Cancer

Piperigkou, Zoi; Karamanos, Nikos K.

doi:10.3390/cancers14010200

Cited by 2 publications

(3 citation statements)

References 25 publications

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“…11,30 Based on their subcellular distribution and specificity for the ECM components, MMPs are divided into membranetype matrix MMPs (MT-MMPs), collagenases, gelatinases, stromelysins and matrilysins. 10,31 A loss of MMP activity control can lead to development of several diseases, among them cancer, atherosclerosis and fibrosis. The activities of most MMPs are very low or negligible in normal tissues, but the expression is…”

Section: Functions Of Matrix Metalloproteinases and Their Endogenous ...mentioning

confidence: 99%

“…MMPs are also classified, according to their structure, into eight groups of which five are secreted and three are bound to membranes 11,30 . Based on their subcellular distribution and specificity for the ECM components, MMPs are divided into membrane‐type matrix MMPs (MT‐MMPs), collagenases, gelatinases, stromelysins and matrilysins 10,31 …”

Section: Functions Of Matrix Metalloproteinases and Their Endogenous ...mentioning

confidence: 99%

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Matrix‐based molecular mechanisms, targeting and diagnostics in oral squamous cell carcinoma

Mastronikolis,

Kyrodimos,

Piperigkou

et al. 2024

IUBMB Life

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Oral squamous cell carcinoma (OSCC) is a head and neck cancer (HNC) with a high mortality rate. OSCC is developed in the oral cavity and it is triggered by many etiologic factors and can metastasize both regionally and distantly. Recent research advances in OSCC improved our understanding on the molecular mechanisms involved in and the initiation of OSCC metastasis. The key roles of the extracellular matrix (ECM) in OSCC are an emerging area of intensive research as the ECM macromolecular network is actively involved in events that regulate cellular morphological and functional properties, transcription and cell signaling mechanisms in invasion and metastasis. The provisional matrix that is formed by cancer cells is profoundly different in composition and functions as compared with the matrix of normal tissue. Fibroblasts are mainly responsible for matrix production and remodeling, but in cancer, the tumor matrix in the tumor microenvironment (TME) also originates from cancer cells. Even though extensive research has been conducted on the role of ECM in regulating cancer pathogenesis, its role in modulating OSCC is less elucidated since there are several issues yet to be fully understood. This critical review is focused on recent research as to present and discuss on the involvement of ECM macromolecular effectors (i.e., proteoglycans, integrins, matrix metalloproteinases) in OSCC development and progression.

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Section: Functions Of Matrix Metalloproteinases and Their Endogenous ...mentioning

confidence: 99%

Section: Functions Of Matrix Metalloproteinases and Their Endogenous ...mentioning

confidence: 99%

Matrix‐based molecular mechanisms, targeting and diagnostics in oral squamous cell carcinoma

Mastronikolis,

Kyrodimos,

Piperigkou

et al. 2024

IUBMB Life

Self Cite

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“…The landscape by which the biology of ECM regulates cell functionality is complex. ECM effects on the cells can be differentially mediated either by the direct binding of cell surface receptors or co-receptors that modulates cell anchorage, mechanotransduction and intracellular signaling pathways, or by the remodeling due to aberrant presentation of growth factors and the actions of enzymes [ 41 , 42 ]. The various ECM macromolecules implicated in main diseases are presented in Table 2 .…”

Section: Ecm-mediated Cell Signaling and Functional Propertiesmentioning

confidence: 99%

Trends in extracellular matrix biology

et al. 2022

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Extracellular matrixes (ECMs) are intricate 3-dimensional macromolecular networks of unique architectures with regulatory roles in cell morphology and functionality. As a dynamic native biomaterial, ECM undergoes constant but tightly controlled remodeling that is crucial for the maintenance of normal cellular behavior. Under pathological conditions like cancer, ECM remodeling ceases to be subjected to control resulting in disease initiation and progression. ECM is comprised of a staggering number of molecules that interact not only with one another, but also with neighboring cells via cell surface receptors. Such interactions, too many to tally, are of paramount importance for the identification of novel disease biomarkers and more personalized therapeutic intervention. Recent advances in big data analytics have allowed the development of online databases where researchers can take advantage of a stochastic evaluation of all the possible interactions and narrow them down to only those of interest for their study, respectively. This novel approach addresses the limitations that currently exist in studies, expands our understanding on ECM interactions, and has the potential to advance the development of targeted therapies. In this article we present the current trends in ECM biology research and highlight its importance in tissue integrity, the main interaction networks, ECM-mediated cell functional properties and issues related to pharmacological targeting.

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Matrix Effectors and Cancer

Abstract: Extracellular matrices (ECMs) are highly dynamic three-dimensional structural meshworks composed of macromolecules, such as proteoglycans/glycosaminoglycans (PGs/GAGs), collagens, laminins, elastin, (glyco)proteins, and matrix-degrading enzymes, such as proteases and glycosidases [...]

Cited by 2 publications

References 25 publications

Matrix‐based molecular mechanisms, targeting and diagnostics in oral squamous cell carcinoma

Matrix‐based molecular mechanisms, targeting and diagnostics in oral squamous cell carcinoma

Trends in extracellular matrix biology

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