Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry of Synthetic Polymers, 5. Analysis of Poly(propylene oxide)s by Coupled Liquid Chromatography at the Critical Point of Adsorption and MALDI-TOF Mass Spectrometry

Keil, C.; Esser, E.; Pasch, H.

doi:10.1002/1439-2054(20010301)286:3<161::aid-mame161>3.3.co;2-q

Cited by 6 publications

(8 citation statements)

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“…Using a column size of 250 mm x 4.6 mm I.D. and a flow rate of 1 mL/min, analysis time is typically around 30 -40 min per sample [4,9,[10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Fast HPLC analysis of poly(ethylene oxide)s for highthroughput experimentation

Pasch¹,

Brüll²,

Cabrera³

2005

E-Polymers

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Liquid chromatography of polymers is traditionally a slow technique with analysis times of typically 30 min per sample. For the application of liquid chromatographic techniques in combinatorial materials research the analysis time per sample must be reduced considerably. For fast high performance liquid chromatography (HPLC) small columns and new stationary phases with improved separation efficiencies can be used. HPLC separations of poly(ethylene oxide)s with different end groups can be conducted in less than 4 min. Accordingly, with new column technology and optimized separation methods time savings of more than 90% can be achieved as compared to conventional technology.

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“…Using a column size of 250 mm x 4.6 mm I.D. and a flow rate of 1 mL/min, analysis time is typically around 30 -40 min per sample [4,9,[10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Fast HPLC analysis of poly(ethylene oxide)s for highthroughput experimentation

Pasch¹,

Brüll²,

Cabrera³

2005

E-Polymers

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“…These techniques enable the ionization of large nonvolatile molecules with good integrity, thus allowing determination of the weight of intact polymer molecules by MS. However, to study the heterogeneity of complex polymer systems at the molecular level, it is vital that MALDI or ESI-MS is combined with a suitable separation technique. − MALDI is the newest and reputedly most promising ionization method for synthetic polymers . Thanks to the emergence of MALDI, polymer scientists have taken a greater interest in MS .…”

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confidence: 99%

“…In polymer LC, critical conditions refer to a separation in which retention is independent of the number of monomeric units in a homopolymer chain . Under critical conditions, differences in retention (i.e., selectivity) are solely caused by the end groups and by other (functional) groups present in the polymer molecules.…”

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confidence: 99%

Mass Spectrometric Characterization of Functional Poly(methyl methacrylate) in Combination with Critical Liquid Chromatography

et al. 2003

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State-of-the-art techniques for the mass spectrometric characterization of synthetic polymers have been applied to functional poly(methyl methacrylate), synthesized by reversible addition-fragmentation chain-transfer (RAFT) polymerization. The polymers were first separated effectively according to functionality by liquid chromatography (LC) at the critical conditions (i.e., almost no influence of molecular weight on retention). The separated polymers were characterized off-line by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), and both off-line and on-line by LC-electrospray-ionization-quadrupole-TOF-MS (LC-ESI-QTOF- MS). The on-line ESI experiments confirmed a clear baseline separation of the hydroxyl-functional prepolymers according to the number of hydroxyl groups. Labile end groups of PMMA, such as the dithioester group, were lost in the MALDI-TOF-MS experiments, while they were observed intact in the ESI-QTOF-MS spectra. This indicates that in the present case ESI is a much softer ionization technique than is MALDI. The ESI-MS experiments provided direct evidence that the RAFT polymers still exhibited living characteristics in the form of the dithio moiety.

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“…In particular, the functionality type analysis of PEO can be conducted efficiently by liquid chromatography at the critical point of adsorption (LC‐CC). Under these conditions, the separation is independent of the oligomer chain length and occurs only according to the endgroups 2–5. The molar mass separation of the oligomers can be conducted by size‐exclusion chromatography (SEC) 6–8.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Fatty Alcohol Ethoxylates Regarding Chain Length and Endgroups by MALDI‐TOF MS Using Collision‐Induced Dissociation

Mass

Rode

Rittig

et al. 2012

Macro Chemistry & Physics

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MALDI-TOF MS is used to analyze the chain lengths and endgroups of fatty alcohol ethoxylates based on the fragmentation behavior in collision-induced dissociation. MALDI-CID-TOF 2 of the ethoxylates results in complex fragmentation patterns that mirror the fragmentation of the ethylene oxide oligomer chain and the fatty alocohol endgroups. Characteristic fragment patterns are obtained that facilitate the interpretation of the fragmentation behavior of the fatty alcohol ethoxylates. Linear and branched endgroups can be differentiated and specifi c fragments are identifi ed that are characteristic for the cleavage between the polymer chain and the endgroup. These "marker" fragments are used to determine the oligomer chain length and the number of carbons per endgroup.

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Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry of Synthetic Polymers, 5. Analysis of Poly(propylene oxide)s by Coupled Liquid Chromatography at the Critical Point of Adsorption and MALDI-TOF Mass Spectrometry

Cited by 6 publications

References 0 publications

Fast HPLC analysis of poly(ethylene oxide)s for highthroughput experimentation

Fast HPLC analysis of poly(ethylene oxide)s for highthroughput experimentation

Mass Spectrometric Characterization of Functional Poly(methyl methacrylate) in Combination with Critical Liquid Chromatography

Analysis of Fatty Alcohol Ethoxylates Regarding Chain Length and Endgroups by MALDI‐TOF MS Using Collision‐Induced Dissociation

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