Matrix-assisted DOSY

Day, Iain J.

doi:10.1016/j.pnmrs.2019.09.001

Cited by 14 publications

(3 citation statements)

References 170 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By means of this method relatively small differences of the order of 1% in diffusion coefficient can be resolved. Matrix-assisted DOSY improved diffusion resolution by the addition of a co-solute (e.g., polymer micelles, surfactants), which modulates the diffusion properties of components of interest [52,71]. The selection of the appropriate matrix plays a key role in this technique, due to the fact that the modulation of the observed diffusion coefficient depends on differential interaction between the matrix and analytes.…”

Section: Diffusion Ordered Spectroscopy (Dosy)mentioning

confidence: 99%

The Application of NMR Spectroscopy and Chemometrics in Authentication of Spices

Pacholczyk-Sienicka,

Ciepielowski,

Albrecht

2023

Analysis of Food Spices

View full text Add to dashboard Cite

show abstract

Section: Diffusion Ordered Spectroscopy (Dosy)mentioning

confidence: 99%

The Application of NMR Spectroscopy and Chemometrics in Authentication of Spices

Pacholczyk-Sienicka,

Ciepielowski,

Albrecht

2023

Analysis of Food Spices

View full text Add to dashboard Cite

show abstract

“…A possible way to resolve this problem is to use additives, including surfactants, polymers, lanthanide shift reagents, and chromatographic stationary phases to modify the diffusion properties of mixtures. , The interaction between the additive and analytes amplifies the differences in the apparent diffusion coefficients among analytes. These approaches are useful in obtaining the NMR spectra of pure components from mixtures.…”

Section: Introductionmentioning

confidence: 99%

Retrieving Spectra of Pure Components from the DOSY-NMR Experiment via a Comprehensive Approach Involving the 2D Asynchronous Spectrum, 2D Quotient Spectrum, and Genetic Algorithm Refinement

et al. 2022

Anal. Chem.

View full text Add to dashboard Cite

When diffusion coefficients of different components in a mixture are similar, NMR spectra of pure individual components are difficult to be obtained via a diffusion-ordered spectroscopy (DOSY) experiment. Two-dimensional correlation spectroscopy (2D-COS) is used to analyze the data from the DOSY experiment. Through the properties of the systematic absence of cross-peak (SACP) in the 2D asynchronous spectra, spectra of pure components can be obtained even if their diffusion coefficients are similar. However, fluctuations in peak-position and peak-width are often unavoidable in NMR spectra, which makes SACPs unrecognizable. To address the problem, a 2D quotient spectrum is used to identify the masked SACPs. However, undesirable interference peaks due to the fluctuations in peak-position and peak-width are still present when we extract a spectrum of a component by slicing the 2D asynchronous spectrum across the SACP. A genetic algorithm (GA) is used to select a suitable subset of spectra where the diversities of peak-position and peak-width are significantly reduced. Then, we used the selected spectra to construct a refined 2D asynchronous spectrum so that the spectra of pure components with significant attenuated interference can be obtained. The above approach has been proven to be effective on a model system and a real-world example, demonstrating that 2D-COS possesses a bright perspective in the analysis of the bilinear data from DOSY experiments.

show abstract

“…In liquid chromatography, the translation speed of each component of mixtures can be selectively changed by interacting with the stationary phase [25,26]. Research has found that adding a conventional stationary phase used in HPLC as a matrix to the NMR tube, such as silica gel, can enhance the separation performance of the NMR method and achieve the purpose of differentiation [27][28][29][30][31][32][33]. The reason is that the interaction between the matrix and analytes can be used to enlarge the apparent diffusion coefficient differences between similar analyte molecules.…”

Section: Introductionmentioning

confidence: 99%

Matrix-Assisted DOSY for Analysis of Indole Alkaloid Mixtures

You

Wang

et al. 2021

Molecules

View full text Add to dashboard Cite

Diffusion-ordered spectroscopy (DOSY) is a powerful tool for investigating mixtures and identifying peaks of chemical components. However, similar diffusion coefficients of the components, particularly for complex mixtures that contain crowded resonances, limit resolution and restrict application of the DOSY technique. In this paper, matrix-assisted DOSY were used to explore whether the diffusion resolution of a complex model involving indole alkaloid mixtures can be realized. Furthermore, we investigated the influence of different factors on the separation effect. The results showed that the changes in diffusion coefficient differences were achieved more obviously when using sodium dodecyl sulfate (SDS) micelles as the matrix. In addition, we also found that increasing the concentration of SDS can improve the resolution of the DOSY spectrum. Finally, after investigating the influence factors and NMR conditions, we demonstrated the applications of the SDS-assisted DOSY on analyzing the total alkaloid extract of Alstonia Mairei, and the virtual separation of mixtures was achieved.

show abstract

Matrix-assisted DOSY

Cited by 14 publications

References 170 publications

The Application of NMR Spectroscopy and Chemometrics in Authentication of Spices

The Application of NMR Spectroscopy and Chemometrics in Authentication of Spices

Retrieving Spectra of Pure Components from the DOSY-NMR Experiment via a Comprehensive Approach Involving the 2D Asynchronous Spectrum, 2D Quotient Spectrum, and Genetic Algorithm Refinement

Matrix-Assisted DOSY for Analysis of Indole Alkaloid Mixtures

Contact Info

Product

Resources

About