Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells

Jiang, Hua; Hou, Chun; Zhang, Shu Bing; Xie, Hai; Zhou, Wenchen; Qi, Jin; Cheng, Xiuwen; Qian, Ruo Lan; Zhang, Xue Jun

doi:10.1016/j.ejphar.2006.12.017

Cited by 86 publications

(68 citation statements)

References 31 publications

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“…In K562 cells, matrine was shown to inhibit cell proliferation and induce apoptosis via the mitochondrial pathway in a time-and dose-dependent manner. Analyses showed that E2F-1 and Apaf-1 were upregulated and that caspase-9 and -3 were activated after the exposure to matrine [21] . Li et al [22] identified 128 miRNAs exhibiting >2-fold expression changes in matrine-treated cells relative to their expression levels in untreated cells.…”

Section: Introductionmentioning

confidence: 99%

Anti-tumor activities of active ingredients in Compound Kushen Injection

Wang¹,

et al. 2015

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Kushen (Radix Sophorae Flavescentis) has a long history of use for the treatment of tumors, inflammation and other diseases in traditional Chinese medicine. Compound Kushen Injection (CKI) is a mixture of natural compounds extracted from Kushen and Baituling (Rhizoma Smilacis Glabrae). The main principles of CKI are matrine (MT) and oxymatrine (OMT) that exhibit a variety of pharmacological activities, including anti-inflammatory, anti-allergic, anti-viral, anti-fibrotic and cardiovascular protective effects. Recent evidence shows that these compounds also produce anti-cancer actions, such as inhibiting cancer cell proliferation, inducing cell cycle arrest, accelerating apoptosis, restraining angiogenesis, inducing cell differentiation, inhibiting cancer metastasis and invasion, reversing multidrug resistance, and preventing or reducing chemotherapy-and/or radiotherapy-induced toxicity when combined with chemotherapeutic drugs. In this review, we summarize recent progress in studying the anti-cancer activities of MT, OMT and CKI and their potential molecular targets, which provide clues and references for further study.

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Section: Introductionmentioning

confidence: 99%

Anti-tumor activities of active ingredients in Compound Kushen Injection

Wang¹,

et al. 2015

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“…Cumulative data have demonstrated that matrine exerts anticancer effect on many series of human cancer cells including lung cancer (16), hepatoma (16), breast cancer (17), pancreatic cancer (18), prostate cancer (19,20) and colon cancer (21). Upregulation of protein E2F-1 and activation of caspases contribute to matrine-induced leukemia cell proliferation inhibition and apoptosis (15). For MDA-MB-231 breast cancer cells, matrine has been demonstrated to inhibit cell proliferation by reducing the ratios of Bcl-2/Bax protein and mRNA levels Matrine induction of reactive oxygen species activates p38 leading to caspase-dependent cell apoptosis in non-small cell lung cancer cells…”

Section: Introductionmentioning

confidence: 99%

“…Quinolizidine alkaloids have been found to be its chief active components in Sophora flavescens including matrine, oxymatrine, sophocarpine, sophoridine and other alkaloids (9). Basic and clinical studies have shown that these alkaloids possess a variety of pharmacological effects including anti-inflammation (10,11), immunity-regulation (12), antivirus (6) and antitumor action (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Matrine induction of reactive oxygen species activates p38 leading to caspase-dependent cell apoptosis in non-small cell lung cancer cells

et al. 2013

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Abstract. Non-small cell lung carcinoma (NSCLC) is one of the most refractory cancers in the clinic; it is insensitive to chemotherapy and is usually excised. However, screening natural compounds from herbs is also considered a possible method for its therapy. In the present study, we investigated whether matrine, a natural compound isolated from Sophora flavescens Ait. and exerting an inhibitory effect on lung cancer cells, also indicates inhibition on NSCLC cells and elucidated its molecular mechanism. Firstly, it is confirmed that matrine induces apoptosis of human NSCLC cells with anti-apoptotic factors inhibited and dependent on caspase activity. In addition, we found that matrine increases the phosphorylation of p38 but not its total protein, and inhibition of the p38 pathway with SB202190 partially prevents matrine-induced apoptosis. Furthermore, matrine generates reactive oxygen species (ROS) in a dose-and time-dependent manner, which is reversed by pretreatment with N-acetyl-L-cysteine (NAC). Additionally, inhibition of cell proliferation and increase of phosphorylation of p38 was also partially reversed by NAC. Collectively, matrine activates p38 pathway leading to a caspase-dependent apoptosis by inducing generation of ROS in NSCLC cells and may be a potential chemical for NSCLC.

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“…Recently, some studies displayed that matrine had potent anti-tumor bioeffect against various cancer cell lines by inhibiting and inducing apoptosis of gastric and cervical cancer cells, prostate cancer cells, leukemia and glioma cells (Hu et al, 2005;Liu et al, 2006;Jiang et al, 2007;Luo et al, 2007;Zhang et al, 2007;Liu et al, 2008;Zhang et al, 2009;Zhang et al, 2012a;Tan et al, 2013;), and also suppressed invasiveness and malignant of melanoma cell line A375 in vitro (Croce and Calin, 2005).…”

Section: Introductionmentioning

confidence: 99%