Matrine inhibits ovarian cancer cell viability and promotes apoptosis by regulating the ERK/JNK signaling pathway via p38MAPK

Liang, Xin; Jian-xin, JU

doi:10.3892/or.2021.8033

Cited by 10 publications

(8 citation statements)

References 34 publications

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“…Recent studies confirmed the antineoplasm effect of matrine on MCF-7 breast cancer and A549 non-small cell lung cancer cell lines by inhibiting AKT/mTOR axis [38,39]. Additionally, it reduced tumor growth of ovarian cancer cells in vivo by inducing the expression of ERK and JNK (c-Jun N-terminal kinase) pathways [40]. Matrine 30 also exerted a significant effect in drug-resistant tumors by inducing apoptosis and inhibiting efflux-pump activity [41,42].…”

Section: 6-naphthyridine Derivativesmentioning

confidence: 93%

“…They were documented to induce apoptosis in cancer cells in both p53-dependent and p53-independent manner [23,25,148,167]. Moreover, the compounds interfere with procytotoxic signaling pathways, i.a., AKT/mTOR, ERK, JNK, WNT [38][39][40]62]. Antineoplasm properties against drug-resistant tumors could be elucidated by inhibiting efflux-pumps activity, however, this topic requires further study [41,42].…”

Section: Naphthyridines Molecular Mechanisms Of Action-what Do We Know?mentioning

confidence: 99%

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Biological Activity of Naturally Derived Naphthyridines

2021

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Marine and terrestrial environments are rich sources of various bioactive substances, which have been used by humans since prehistoric times. Nowadays, due to advances in chemical sciences, new substances are still discovered, and their chemical structures and biological properties are constantly explored. Drugs obtained from natural sources are used commonly in medicine, particularly in cancer and infectious diseases treatment. Naphthyridines, isolated mainly from marine organisms and terrestrial plants, represent prominent examples of naturally derived agents. They are a class of heterocyclic compounds containing a fused system of two pyridine rings, possessing six isomers depending on the nitrogen atom’s location. In this review, biological activity of naphthyridines obtained from various natural sources was summarized. According to previous studies, the naphthyridine alkaloids displayed multiple activities, i.a., antiinfectious, anticancer, neurological, psychotropic, affecting cardiovascular system, and immune response. Their wide range of activity makes them a fascinating object of research with prospects for use in therapeutic purposes.

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Section: 6-naphthyridine Derivativesmentioning

confidence: 93%

Section: Naphthyridines Molecular Mechanisms Of Action-what Do We Know?mentioning

confidence: 99%

Biological Activity of Naturally Derived Naphthyridines

2021

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“…Xin et al 116 found that matrine significantly inhibited the viability, migration and invasion of ovarian cancer cells, and induced apoptosis. In addition, matrine treatment significantly upregulated the expression levels of p38MAPK, p-ERK/ERK, and p-JNK/JNK, while p38MAPK knockdown significantly downregulated the expression levels of p-ERK/ERK and p-JNK/JNK, promoting the viability, migration and invasion of ovarian cancer cells.…”

Section: Matrine Exerts Pharmacological Effects Through the Mapk Sign...mentioning

confidence: 99%

Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review

Lin¹,

He²,

Wu³

et al. 2022

DDDT

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As The main effective monomer of the traditional Chinese medicine Sophora flavescens Ait , matrine has a broad scope of pharmacological activities such as anti-tumor, anti-inflammatory, analgesic, anti-fibrotic, anti-viral, anti-arrhythmia, and improving immune function. These actions explain its therapeutic effects in various types of tumors, cardiopathy, encephalomyelitis, allergic asthma, rheumatoid arthritis (RA), osteoporosis, and central nervous system (CNS) inflammation. Evidence has shown that the mechanism responsible for the pharmacological actions of matrine may be via the activation or inhibition of certain key molecules in several cellular signaling pathways including the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR), transforming growth factor-β/mothers against decapentaplegic homolog (TGF-β/Smad), nuclear factor kappa B (NF-κB), Wnt (wingless/ integration 1)/β-catenin, mitogen-activated protein kinases (MAPKs), and Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathways. This review comprehensively summarizes recent studies on the pharmacological mechanisms of matrine to provide a theoretical basis for molecular targeted therapies and further development and utilization of matrine.

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“…The main component of Sophora flavescens preparations is matrine, which has broad pharmacological properties, including sedation, analgesia (9), antiviral (10), anti-inflammatory (11), antifibrotic (12) antitumor and immunoregulatory activity (13,14), as well as other effects (15). Previous studies have investigated the inhibitory effects of matrine on a variety of tumor cells including cervical cancer (16)(17)(18)(19)(20). Matrine combined with chemotherapy drugs, such as cisplatin, docetaxel and adriamycin, may have antitumor activity (21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

Matrine exerts antitumor activity in cervical cancer by protective autophagy via the Akt/mTOR pathway in vitro and in vivo

Zhang

et al. 2022

Oncol Lett

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Matrine is a quinazoline alkaloid extracted from Sophora flavescens. The aim of the present study was to determine whether matrine can induce autophagy in the human HeLa and SiHa cervical cancer cell lines in vitro and in vivo. Cell viability assay was used to assess the suppressive effect of matrine and cisplatin on the proliferation of HeLa and SiHa cells. A total of 28 4-week-old female BALB/c nude mice were used for the in vivo study. Autophagy and protein expression were observed via transmission electron microscopy, monodansylcadaverine and immunohistochemical staining and western blotting. The inhibitory effect of matrine on the proliferation of cervical cancer cells was time-and dose-dependent. The combination of matrine and cisplatin synergistically inhibited the proliferation of cervical cancer cells in vitro and in vivo. Transmission electron microscopy showed that after the addition of matrine, numerous autophagosomes and autophagolysosomes were observable in HeLa and SiHa cells, as demonstrated by monodansylcadaverine staining. Western blotting and immunohistochemical staining showed that as the concentration of matrine increased, the expression of the autophagy marker LC3A/B-II also increased significantly in vitro and in vivo. These findings suggested that matrine inhibited the proliferation of cervical cancer cells and induced autophagy by inhibiting the Akt/mTOR signaling pathway. Thus, matrine may represented a potential candidate in combination therapy for cervical cancer as an inducer of autophagy.

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Matrine inhibits ovarian cancer cell viability and promotes apoptosis by regulating the ERK/JNK signaling pathway via p38MAPK

Cited by 10 publications

References 34 publications

Biological Activity of Naturally Derived Naphthyridines

Biological Activity of Naturally Derived Naphthyridines

Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review

Matrine exerts antitumor activity in cervical cancer by protective autophagy via the Akt/mTOR pathway in vitro and in vivo

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