Matrine induces papillary thyroid cancer cell apoptosis in vitro and suppresses tumor growth in vivo by downregulating miR-182-5p

Fu, Songbo; Zhao, Nan; Jing, Gaojing; Yang, Xiaomei; Liu, Jingfang; Zhen, Donghu; Tang, Xulei

doi:10.1016/j.biopha.2020.110327

Cited by 13 publications

(11 citation statements)

References 17 publications

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“…Likewise, miR-183 has been shown to act as an important target in the regulation of the Wnt/β-catenin pathway in different cancer types [43][44][45]. On the other hand, miR-182 has been associated with tumor progression and chemoresistance in various tumors [46][47][48] and with suppression of apoptosis in papillary thyroid cancer [49]. miR-375 and miR-96 were shown to affect various pathways in different tumors and have been reported to regulate the PI3K/Akt pathway in thyroid cancer [50,51].…”

Section: Discussionmentioning

confidence: 99%

Epigenetic Silencing of SOX15 Is Controlled by miRNAs rather than Methylation in Papillary Thyroid Cancer

et al. 2021

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Object. Thyroid cancer (TC) is a rare type of cancer which occurs as a result of environmental and genetic factors. Although different types of genetic and epigenetic changes are associated with TC, the molecular mechanism still remains unclear. SRY-box transcription factor 15 (SOX15) is an important transcription factor, and its expression is altered in many cancer types by epigenetic modifications. Recently, miR-147b overexpression has been associated with SOX15 silencing in TC. Methods. In this study, qRT-PCR was used to investigate the expression levels of the SOX15 gene and of miR-182, miR-183, miR-375, and miR-96 in thyroid tumors and adjacent noncancerous tissues. We also investigated the methylation status of the SOX15 promoter by methylation-specific PCR in tumors and adjacent noncancerous tissues. Results. We observed a statistically significant downregulation of SOX15 expression in tumors compared to noncancerous tissue samples. The methylation levels of tumors and matched noncancerous tissues were similar, but miR-182, miR-183, and miR-375 expression levels were elevated in tumor tissues compared to noncancerous tissue samples. Conclusions. Our results indicate that SOX15 gene expression is associated with the pathogenesis of papillary thyroid carcinoma (PTC), and the epigenetic control of the SOX15 gene is regulated by miRNAs rather than by promoter methylation.

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Section: Discussionmentioning

confidence: 99%

Epigenetic Silencing of SOX15 Is Controlled by miRNAs rather than Methylation in Papillary Thyroid Cancer

et al. 2021

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“…The matrine ( 246 ) has been proved in many studies to inhibit cancer cell proliferation and metastasis, arrest cell cycle, promote apoptosis, and reduce the toxicity of anticancer drugs with reversing effects on anticancer drug resistance (Chen et al 2019d ; Cao and He 2020 ; Fu et al 2020 ; Liu et al 2020a , b ; Zhang et al 2020a ). A nontoxic concentration of Matrine ( 246 ) also facilitated intrinsic apoptosis pathway and suppressed the expression of ATP-binding cassette subfamily B member 1 drug transport (Chen et al 2019d ).…”

Section: Biological Effectsmentioning

confidence: 99%

“…A nontoxic concentration of Matrine ( 246 ) also facilitated intrinsic apoptosis pathway and suppressed the expression of ATP-binding cassette subfamily B member 1 drug transport (Chen et al 2019d ). The same compound induced papillary thyroid cancer cell apoptosis in vitro and suppressed the in vivo tumor growth by downregulating miR-182-5p (Li et al 2019b ; Fu et al 2020 ). The inhibitory effect of 246 on human nasopharyngeal carcinoma CNE-2 cells was reported (Wang et al 2018c ).…”

Section: Biological Effectsmentioning

confidence: 99%

Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives

2021

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Sophora is deemed as one of the most remarkable genera of Fabaceae, and the third largest family of flowering plants. The genus Sophora comprises approximately 52 species, 19 varieties, and 7 forms that are widely distributed in Asia and mildly in Africa. Sophora species are recognized to be substantial sources of broad spectrum biopertinent secondary metabolites namely flavonoids, isoflavonoids, chalcones, chromones, pterocarpans, coumarins, benzofuran derivatives, sterols, saponins (mainly triterpene glycosides), oligostilbenes, and mainly alkaloids. Meanwhile, extracts and isolated compounds from Sophora have been identified to possess several health-promising effects including anti-inflammatory, anti-arthritic, antiplatelets, antipyretic, anticancer, antiviral, antimicrobial, antioxidant, anti-osteoporosis, anti-ulcerative colitis, antidiabetic, anti-obesity, antidiarrheal, and insecticidal activities. Herein, the present review aims to provide comprehensive details about the phytochemicals and biological effects of Sophora species. The review spotlighted on the promising phytonutrients extracted from Sophora and their plethora of bioactivities. The review also clarifies the remaining gaps and thus qualifies and supplies a platform for further investigations of these compounds.

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“…For example, matrine suppresses the migration and invasion capacities of lung, prostate, and breast cancer cells via downregulating the levels of C-X-C motif chemokine receptor 4 (CXCR4) [ 107 ]. In addition, it was demonstrated that matrine represses miR-182-5p and miR-93-5p levels in papillary thyroid and gastric cancer cells, respectively, and retards cancer growth in vivo [ 21 , 96 ] ( Figure 1 and Table 3 ). In particular, the overexpression of miR-182-5p (a member of the miR-183-96-182 cluster) can block the matrine-mediated activation of caspase-3 in papillary thyroid cancer cells [ 21 ].…”

Section: Oncogenic Mirnas Inhibited By Phytochemicals Currently Evmentioning

confidence: 99%

“…In addition, it was demonstrated that matrine represses miR-182-5p and miR-93-5p levels in papillary thyroid and gastric cancer cells, respectively, and retards cancer growth in vivo [ 21 , 96 ] ( Figure 1 and Table 3 ). In particular, the overexpression of miR-182-5p (a member of the miR-183-96-182 cluster) can block the matrine-mediated activation of caspase-3 in papillary thyroid cancer cells [ 21 ]. In addition, miR-93-5p (a member of the miR-106b-25 cluster) positively affects cell proliferation and the migration of gastric cancer cells via directly targeting AHNAK nucleoprotein (AHNAK), which is a negative regulator of the EMT process [ 96 , 108 ].…”

Section: Oncogenic Mirnas Inhibited By Phytochemicals Currently Evmentioning

confidence: 99%

Participation of MicroRNAs in the Treatment of Cancer with Phytochemicals

et al. 2020

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Cancer is a global health concern and one of the main causes of disease-related death. Even with considerable progress in investigations on cancer therapy, effective anti-cancer agents and regimens have thus far been insufficient. There has been compelling evidence that natural phytochemicals and their derivatives have potent anti-cancer activities. Plant-based anti-cancer agents, such as etoposide, irinotecan, paclitaxel, and vincristine, are currently being applied in medical treatments for patients with cancer. Further, the efficacy of plenty of phytochemicals has been evaluated to discover a promising candidate for cancer therapy. For developing more effective cancer therapy, it is required to apprehend the molecular mechanism deployed by natural compounds. MicroRNAs (miRNAs) have been realized to play a pivotal role in regulating cellular signaling pathways, affecting the efficacy of therapeutic agents in cancer. This review presents a feature of phytochemicals with anti-cancer activity, focusing mainly on the relationship between phytochemicals and miRNAs, with insights into the role of miRNAs as the mediators and the regulators of anti-cancer effects of phytochemicals.

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Matrine induces papillary thyroid cancer cell apoptosis in vitro and suppresses tumor growth in vivo by downregulating miR-182-5p

Cited by 13 publications

References 17 publications

Epigenetic Silencing of SOX15 Is Controlled by miRNAs rather than Methylation in Papillary Thyroid Cancer

Epigenetic Silencing of SOX15 Is Controlled by miRNAs rather than Methylation in Papillary Thyroid Cancer

Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives

Participation of MicroRNAs in the Treatment of Cancer with Phytochemicals

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