Matrine exerts an anti‐tumor effect via regulating HN1 in triple breast cancer both in vitro and in vivo
Qiusheng Guo,
Yuan Yu,
Wanfen Tang
et al.
Abstract:The treatment of triple‐negative breast cancer (TNBC) cannot meet medical needs, and it is urgent to find new drugs for intervention. This study aimed to investigate the anti‐tumor effect of matrine on the proliferation and apoptosis of TNBC cells based on HN1 regulation in vitro and in vivo. TNBC cell lines (MDA‐MB‐453 and HCC‐1806) were treated with varying concentrations of matrine (0, 1.0, 2.0, 3.0, 4.0, and 5.0 mM). CCK‐8, colony formation assay, transwell assay, and flow cytometry assay were employed to … Show more
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