Matrine- and oxymatrine-imprinted monodisperse polymers prepared by precipitation polymerization and their applications for the selective extraction of matrine-type alkaloids from Sophora flavescens Aiton

Extraction and identification of matrine‐type alkaloids from Sophora moorcroftiana using double‐templated molecularly imprinted polymers with HPLC–MS/MS

“…Because MT and OMT are both Lewis bases, acidic MAA was used as the functional monomer. Additionally, Funaya and Haginaka also reported that when the matrine and oxymatrine were used as the mono‐disperse template, the MAA was selected as functional monomer which exhibited good adsorption capacity and recognition performance to the target molecule . The UV‐Vis results (Figure ) were used to study interactions involved in the formation of D‐MIPs on addition of MAA in acetonitrile to 0.01 mmol of the two templates (also in acetonitrile).…”

“…Because MT and OMT are both Lewis bases, acidic MAA was used as the functional monomer. Additionally, Funaya and Haginaka also reported that when the matrine and oxymatrine were used as the mono-disperse template, the MAA was selected as functional monomer which exhibited good adsorption capacity and recognition performance to the target molecule [8].…”

“…There have been a few reports on the separation of these three compounds mainly from the root of Sophora flavescens Ait. [8], Sophora alopecuroides L. [9], and radix Sophorae tonkinesis [10,11]. Extractions of these components have been performed using SPE, CE, and pH-zone-refining CCC [12,13].…”

Transcriptome Analysis of Nine Tissues to Discover Genes Involved in the Biosynthesis of Active Ingredients in <i>Sophora flavescens</i>

“…1) As a widely distributed and effective herbal medicine, it severed as a cure for asthma, sores, gastrointestinal hemorrhage, diarrhea, allergy, inflammation in eastern Asian countries. 2,3) Main chemical components of S. flavescens include flavonoids (1.5%), alkaloids (3.3%), alkylxanthones, quinones, triterpene glycosides, fatty acids as well as essential oils and recently, several clinical studies reported that alkaloids of S. flavescens were efficacious in treating various types of solid tumors (including breast, lung, liver and gastrointestinal tract cancers), which drew close attention to this traditional herbal plant. 1,4) In 1889, the characteristic compound matrine was isolated from the dry roots of S. flavescens by Nagai 5) and then in 1966, Okuda et al confirmed the absolute structure of (+)-matrine.…”

Antipruritic Effect of Matrine

“…Our latest research has concentrated on another Chinese herbal medicine, Sophorae Flavescentis Radix (SFR) [12], which has been used in the treatment of viral hepatitis, cancer, enteritis, viral myocarditis, arrhythmia, and skin diseases in China, Japan and some European countries [13][14][15]. Since SFR has specific therapeutic effects on pruritus and allergic symptoms with less side effects [16,17], it has become an important candidate for researchers in studying antipruritic drugs.…”