Matricellular proteins in cutaneous wound healing

Cárdenas-León, Claudia Griselda; Mäemets-Allas, Kristina; Klaas, Mariliis; Lagus, Heli; Kankuri, Esko; Jaks, Viljar

doi:10.3389/fcell.2022.1073320

Cited by 6 publications

(11 citation statements)

References 283 publications

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“…S9A ). The C2_1 cluster contained chromatin regions associated with Tgfbi (Chr13:56582628-56583028), a gene strongly linked to tissue remodeling and repair 38,39 ( Fig. 3E ).…”

Section: Resultsmentioning

confidence: 99%

Matrix-rigidity cooperates with biochemical cues in M2 macrophage activation through increased nuclear deformation and chromatin accessibility

Shin,

Bayarkhangai,

Tsogtbaataar

et al. 2024

Preprint

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Macrophages encounter a myriad of biochemical and mechanical stimuli across various tissues and pathological contexts. Notably, matrix rigidity has emerged as a pivotal regulator of macrophage activation through mechanotransduction. However, the precise mechanisms underlying the interplay between mechanical and biochemical cues within the nuclear milieu remain elusive. Here we elucidate how the increased matrix rigidity drives macrophages to amplify alternatively-activated (M2 phenotype) signalings cooperatively with biochemical cues (e.g., IL4/13) through altered nuclear mechanics. Notably, we found that reconstructed podosome-like F-actins and contractility induced nucleus deformation, opening nuclear pores, which facilitates nuclear translocation of the key transcription factor STAT6. Furthermore, the altered nuclear mechanics increased chromatin accessibility induced by H3K9 methylation, particularly of M2-associated gene promoters. These cooperative events of the mechano-chemical signaling at the cytoskeletal-to-nuclear domains facilitated M2 transcriptional activation and cellular functions. We further evidenced the rigidity-primed M2 macrophages were immunosuppressive and accumulated in stiffened tumor tissues. This study proposes a mechanism by which matrix mechanics crosstalks with biochemical signals to potentiate macrophage activation through nuclear mechanosensing and chromatin modifications, offering insights into macrophage mechanobiology and its therapeutic modulations.

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“…S9A ). The C2_1 cluster contained chromatin regions associated with Tgfbi (Chr13:56582628-56583028), a gene strongly linked to tissue remodeling and repair 38,39 ( Fig. 3E ).…”

Section: Resultsmentioning

confidence: 99%

Matrix-rigidity cooperates with biochemical cues in M2 macrophage activation through increased nuclear deformation and chromatin accessibility

Shin,

Bayarkhangai,

Tsogtbaataar

et al. 2024

Preprint

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“…Skin wound healing is an intricate process involving the interactions of many ECMs, growth factors, and various cell types [ 3 , 145 , 146 ]. It begins with the injury site filling with blood clotting factors and chemokines to attract leukocytes, including neutrophils, to clean the wounded area.…”

Section: Matricellular Proteins In Stem Cell Regulation During Homeos...mentioning

confidence: 99%

“…The fasciclin family of matricellular proteins (periostin and TGFβ-Induced Protein (TGFBI)) is known to promote wound healing partly due to increased re-epithelialization [ 3 , 44 , 162 ]. Periostin-deficient mice exhibited delayed wound healing with defective re-epithelialization [ 108 ] and myofibroblast activation that facilitates wound contraction [ 158 , 159 ].…”

Section: Matricellular Proteins In Stem Cell Regulation During Homeos...mentioning

confidence: 99%

“…The term matricellular protein was first introduced by Paul Bornstein in the 1990s to describe thrombospondin 1 (TSP1/THBS1), secreted protein acidic rich in cysteine (SPARC), and tenascin C [ 1 ]. Since then, the list has substantially expanded and includes protein families of the cellular communication network (CCN) factors, the fasciclin family, tenascins, galectins, R-Spondins (RSPOs), fibulins, ecto-nucleotide pyrophosphatase/phosphodiesterases, small integrin-binding ligand N-linked glycoproteins, and olfactomedins [ 3 ]. Although matricellular proteins have no direct structural functions, they can bind to structural ECM proteins such as collagens [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin

Raja,

Clarin,

Yanagisawa

2023

IJMS

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Matricellular proteins are secreted extracellular proteins that bear no primary structural functions but play crucial roles in tissue remodeling during development, homeostasis, and aging. Despite their low expression after birth, matricellular proteins within skin compartments support the structural function of many extracellular matrix proteins, such as collagens. In this review, we summarize the function of matricellular proteins in skin stem cell niches that influence stem cells’ fate and self-renewal ability. In the epidermal stem cell niche, fibulin 7 promotes epidermal stem cells’ heterogeneity and fitness into old age, and the transforming growth factor-β—induced protein ig-h3 (TGFBI)—enhances epidermal stem cell growth and wound healing. In the hair follicle stem cell niche, matricellular proteins such as periostin, tenascin C, SPARC, fibulin 1, CCN2, and R-Spondin 2 and 3 modulate stem cell activity during the hair cycle and may stabilize arrector pili muscle attachment to the hair follicle during piloerections (goosebumps). In skin wound healing, matricellular proteins are upregulated, and their functions have been examined in various gain-and-loss-of-function studies. However, much remains unknown concerning whether these proteins modulate skin stem cell behavior, plasticity, or cell–cell communications during wound healing and aging, leaving a new avenue for future studies.

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“…In the proliferation phase, the newly formed ECM provides mechanical support and a survival environment for cells. Cells proliferate and differentiate extensively around the wound, filling the gap in the wound ( Figure 1 C) [ 36 ]. Finally, granulation tissue forms around the wound and new blood vessels are formed.…”

Section: Ecm Dynamics During Wound Healingmentioning

confidence: 99%

Electrospun Nanofiber Scaffolds Loaded with Metal-Based Nanoparticles for Wound Healing

Dang,

Ma,

Yang

et al. 2023

Polymers

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Failures of wound healing have been a focus of research worldwide. With the continuous development of materials science, electrospun nanofiber scaffolds loaded with metal-based nanoparticles provide new ideas and methods for research into new tissue engineering materials due to their excellent antibacterial, anti-inflammatory, and wound healing abilities. In this review, the stages of extracellular matrix and wound healing, electrospun nanofiber scaffolds, metal-based nanoparticles, and metal-based nanoparticles supported by electrospun nanofiber scaffolds are reviewed, and their characteristics and applications are introduced. We discuss in detail the current research on wound healing of metal-based nanoparticles and electrospun nanofiber scaffolds loaded with metal-based nanoparticles, and we highlight the potential mechanisms and promising applications of these scaffolds for promoting wound healing.

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Matricellular proteins in cutaneous wound healing

Cited by 6 publications

References 283 publications

Matrix-rigidity cooperates with biochemical cues in M2 macrophage activation through increased nuclear deformation and chromatin accessibility

Matrix-rigidity cooperates with biochemical cues in M2 macrophage activation through increased nuclear deformation and chromatin accessibility

Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin

Electrospun Nanofiber Scaffolds Loaded with Metal-Based Nanoparticles for Wound Healing

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