Matricaria Chamomilla Extract Improves Diabetic Wound Healing in Rat Models

Nematollahi, Parisa; Aref, Nasrin Mohammadi; Meimandi, Farzaneh Zahmatkesh; Rozei, Seyede Laya; Zaree, Hamidreza; Mirlohi, Seyyed Mohammad Javad; Rafiee, Shima; Mohsenikia, Maryam; Soleymani, Ali; Ashkani-Esfahani, Soheil; Ebrahimi, Alireza; Noorafshan, Ali

doi:10.5812/traumamon.14318

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Previous research has shown that M. chamomilla contains compounds such as chamazulene, alpha‐bisabolol, bisabolol oxides, spiroethers, and flavonoids. These constituents exhibit anti‐inflammatory, antibacterial, and anti‐fungal properties, as highlighted in earlier studies 45 . The efficacy of chamomile in wound healing has been substantiated in studies involving both diabetic and nondiabetic rats.…”

Section: Discussionmentioning

confidence: 79%

“…These constituents exhibit anti‐inflammatory, antibacterial, and anti‐fungal properties, as highlighted in earlier studies. 45 The efficacy of chamomile in wound healing has been substantiated in studies involving both diabetic and nondiabetic rats. For instance, research demonstrated that the topical application of chamomile expedited the healing of burn wounds in rats.…”

Section: Discussionmentioning

confidence: 99%

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Short‐term effect of dressing with Dermaheal ointment in the treatment of diabetic foot ulcer: A double‐blinded randomized controlled clinical trial

Salahi,

Nasiri,

Yazdanpanah

et al. 2024

Health Science Reports

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Background and AimsDiabetic foot ulcers, a major cause of amputations in diabetics, could benefit from natural products as adjuncts to standard care, given the costs and adverse effects of typical therapies. This study aims to evaluate the short‐term effects of dressing with Dermaheal ointment in the treatment of DFUs through a double‐blinded randomized controlled clinical trial.MethodsThis double‐blinded, placebo‐controlled trial included 50 patients with Wagner's ulcer grade I or II, randomly assigned to Dermaheal and placebo groups (received standard treatment and placebo ointment). The ulcer site was dressed daily for four consecutive weeks with either Dermaheal or placebo ointment. Ulcer healing score (using DFU healing checklist), ulcer size with transparent ruler and largest dimension of ulcer, and pain severity using numerical pain rating score (were recorded at five‐time points, including baseline, and on weeks 1, 2, 3, and 4). Also, ulcer healing status was investigated at the trial ended in November 2021.ResultsBoth groups showed significant improvement in ulcer healing over 4 weeks (ptime < 0.001), with more remarkable progress in the Dermaheal group (pgroup = 0.03). At the trial end, complete ulcer healing was also significantly higher in the Dermaheal group compared to the placebo group (56% vs. 12%, p = 0.002). Both groups exhibited a decrease in ulcer size (ptime < 0.001). Considering the baseline ulcer size as a covariate, substantial changes in mean ulcer size were noted in the initial (p = 0.01), second (p = 0.001), third (p = 0.002), and fourth (p = 0.002) weeks of the intervention, showing a preference for the Dermaheal group. However, no significant between‐group difference was observed in pain severity levels.ConclusionDressing with Dermaheal as a topical treatment shows promise in improving healing and reducing the size of diabetic foot ulcers. Further research is needed to confirm these findings' long‐term efficacy.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Short‐term effect of dressing with Dermaheal ointment in the treatment of diabetic foot ulcer: A double‐blinded randomized controlled clinical trial

Salahi,

Nasiri,

Yazdanpanah

et al. 2024

Health Science Reports

View full text Add to dashboard Cite

show abstract

“…A higher wound closure ratio was noted after three days of treatment compared to the control group. No significant differences were observed between the treatment with the gel containing 5 and 10% of the extract [ 93 ]. The wound healing capacity of the methanolic extracts was tested in an excision wound model on the rats’ dorsum, using concentrations of 2.5, 5, and 10%.…”

Section: Phytotherapy In Skin Diseasesmentioning

confidence: 99%

Current Knowledge on Interactions of Plant Materials Traditionally Used in Skin Diseases in Poland and Ukraine with Human Skin Microbiota

Melnyk

Vlasova

Skowrońska

et al. 2022

IJMS

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Skin disorders of different etiology, such as dermatitis, atopic dermatitis, eczema, psoriasis, wounds, burns, and others, are widely spread in the population. In severe cases, they require the topical application of drugs, such as antibiotics, steroids, and calcineurin inhibitors. With milder symptoms, which do not require acute pharmacological interventions, medications, dietary supplements, and cosmetic products of plant material origin are gaining greater popularity among professionals and patients. They are applied in various pharmaceutical forms, such as raw infusions, tinctures, creams, and ointments. Although plant-based formulations have been used by humankind since ancient times, it is often unclear what the mechanisms of the observed beneficial effects are. Recent advances in the contribution of the skin microbiota in maintaining skin homeostasis can shed new light on understanding the activity of topically applied plant-based products. Although the influence of various plants on skin-related ailments are well documented in vivo and in vitro, little is known about the interaction with the network of the skin microbial ecosystem. The review aims to summarize the hitherto scientific data on plant-based topical preparations used in Poland and Ukraine and indicate future directions of the studies respecting recent developments in understanding the etiology of skin diseases. The current knowledge on investigations of interactions of plant materials/extracts with skin microbiome was reviewed for the first time.

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Insights into the mechanisms of diabetic wounds: pathophysiology, molecular targets, and treatment strategies through conventional and alternative therapies

Yadav,

Singh,

Grishina

et al. 2024

Inflammopharmacol

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Matricaria Chamomilla Extract Improves Diabetic Wound Healing in Rat Models

Cited by 4 publications

References 22 publications

Short‐term effect of dressing with Dermaheal ointment in the treatment of diabetic foot ulcer: A double‐blinded randomized controlled clinical trial

Short‐term effect of dressing with Dermaheal ointment in the treatment of diabetic foot ulcer: A double‐blinded randomized controlled clinical trial

Current Knowledge on Interactions of Plant Materials Traditionally Used in Skin Diseases in Poland and Ukraine with Human Skin Microbiota

Insights into the mechanisms of diabetic wounds: pathophysiology, molecular targets, and treatment strategies through conventional and alternative therapies

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