MATLAB language assisted data acquisition and processing in liquid chromatography Orbitrap mass spectrometry: Application to the identification and differentiation of Radix Bupleuri from its adulterants

Shen, Xuan-jing; Zhang, Jian-qing; An, Ya-ling; Yang, Lin; Li, Xiao-lan; Hu, Yun-shu; Sha, Fei; Yao, Chang-liang; Bi, Qi-rui; Qu, Hua; Guo, De-an

doi:10.1016/j.chroma.2023.464544

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…More seriously, B. longiradiatum Turcz. has been reported by Heilongjiang Institute for Drug Control for mistakenly confusing commercial Radix Bupleuri preparations and causing poisoning incidents ( Shen et al, 2024 ). Therefore, identifying and classifying Radix Bupleuri and its adulterants are particularly important in order to prevent similar incidents.…”

Section: Introductionmentioning

confidence: 99%

Feasibility study on the introduction of Micro-CT technology for the identification of Radix Bupleuri and its adulterants

Chen,

Zhuang

et al. 2024

Front. Pharmacol.

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Background:Radix Bupleuri, a kind of Chinese herbal medicine with great clinical use, is often confused with its adulterants, and it is difficult to identify it without certain knowledge. The existing identification methods have their own drawbacks, so a new method is needed to realize the identification of Radix Bupleuri and its adulterants.Methods: We used Micro Computed Tomography (Micro-CT) to perform tomography scans on Radix Bupleuri and its adulterants, performed data screening and data correction on the obtained DICOM images, and then applied 3D reconstruction, data augmentation, and ResNext deep learning model for the classification study.Results: The DICOM images after data screening, data correction, and 3D reconstruction can observe the differences in the microstructure of Radix Bupleuri and its adulterants, thus enabling effective classification and analysis. Meanwhile, the accuracy of classification using the ResNext model reached 75%.Conclusion: The results of this study showed that Micro-CT technology is feasible for the authentication of Radix Bupleuri. The pre-processed and 3D reconstructed tomographic images clearly show the microstructure and the difference between Radix Bupleuri and its adulterants without damaging the internal structure of the samples. This study concludes that Micro-CT technology provides important technical support for the reliable identification of Radix Bupleuri and its adulterants, which is expected to play an important role in the quality control and clinical application of herbs.

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Section: Introductionmentioning

confidence: 99%