Mating pair drives aggressive behavior in female Drosophila

Gaspar, Miguel; Dias, Sophie; Vasconcelos, Maria Luísa

doi:10.1016/j.cub.2022.09.009

Cited by 6 publications

(7 citation statements)

References 64 publications

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“…As in many areas of neuroscience, research on female behavior has been remarkably less extensive. However, recent progress has been made on the identification of female-specific circuitry, the intensity of female agonistic encounters, and the impact of reproductive state on female aggression (Palavicino-Maggio et al 2019;Bath et al 2020;Deutsch et al 2020;Schretter et al 2020;Chiu et al 2021;Gaspar et al 2022). The availability of a large portion of the female brain connectome has allowed the mapping of connections between subpopulations involved in female aggression-for example, aIPg and pC1d (Schretter 2020).…”

Section: Shove Femalesmentioning

confidence: 99%

Fighting Flies: Quantifying and AnalyzingDrosophilaAggression

Fernández

Trannoy

Certel

2023

Cold Spring Harb Protoc

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Aggression is an innate behavior that likely evolved in the framework of defending or obtaining resources. This complex social behavior is influenced by genetic, environmental, and internal factors.Drosophila melanogasterremains an effective and exciting model organism with which to unravel the mechanistic basis of aggression due to its small but sophisticated brain, an impressive array of neurogenetic tools, and robust stereotypical behavioral patterns. The investigations of many laboratories have led to the identification of external and internal state factors that promote aggression, sex differences in the patterns and outcome of aggression, and neurotransmitters that regulate aggression.

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Section: Shove Femalesmentioning

confidence: 99%

Fighting Flies: Quantifying and AnalyzingDrosophilaAggression

Fernández

Trannoy

Certel

2023

Cold Spring Harb Protoc

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“…The olfactory receptor Or47b, expressed ORNs located in at4 trichoid sensilla on the third antennal segment, is involved in several socio-sexual interactions, including male mating success, mating partner preference, and female aggression to mating pairs (12, 26–29). In males, Or47b senses fatty acid methyl ester and fatty acid that affect mating competition and copulation (30, 31).…”

Section: Introductionmentioning

confidence: 99%

“…In males, Or47b senses fatty acid methyl ester and fatty acid that affect mating competition and copulation (30, 31). While Or47b’s role in female aggression is established (12), its involvement in female sexual behaviors is uncertain. For both sexes, the Or47b ORNs project to the VA1v glomeruli, where the VA1v projection neurons receive their signal and project to the mushroom body calyx and lateral horn.…”

Section: Introductionmentioning

confidence: 99%

“…Many species also adapt their reproductive behaviors in response to the social sexual context change (SSCC), involving encounters with new sexual partners or competitors. Understanding the neuronal circuit mechanisms behind female responses to SSCC emerges as a central focus in neuroscience (9)(10)(11)(12). Drosophila melanogaster, the fruit fly, displays various social behaviors like aggregation, aggression, and sexual behavior (13)(14)(15).…”

Section: Main Text Introductionmentioning

confidence: 99%

“…Olfactory receptor neurons (ORNs) in the sensilla of the antennae and maxillary palp are responsible for the detection of long-range volatile pheromones like cVA, while short-range pheromones like 7-T are sensed by neurons on the fore-legs and labellum (16,17,24). The olfactory receptor Or47b, expressed ORNs located in at4 trichoid sensilla on the third antennal segment, is involved in several socio-sexual interactions, including male mating success, mate preference, and female aggression toward mating pairs (12,(26)(27)(28)(29). In males, Or47b senses fatty acid methyl esters and fatty acids that affect mating competition and copulation (30,31).…”

Section: Main Text Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Male cuticular pheromones stimulate removal of the mating plug and promote re-mating through pC1 neurons inDrosophilafemales

Yun,

Kim,

et al. 2023

Preprint

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In birds and insects, females uptake sperm for a specific duration post-copulation known as the ejaculate holding period (EHP) before expelling unused sperm and the mating plug through sperm ejection. Our study uncovered that encountering males or mated females after mating substantially shortens EHP, a phenomenon we term ‘male-inducedEHPshortening (MIES)’. MIES requires Or47b+ olfactory and ppk23+ gustatory neurons, activated by 2-methyltetracosane and 7-Tricosene, respectively. These odorants raise cAMP levels in pC1 neurons, responsible for processing male courtship and regulating female mating receptivity. Elevated cAMP levels in pC1 neurons reduce EHP and reinstate their responsiveness to male courtship cues, promoting re-mating with faster sperm ejection. This study establishes MIES as a genetically tractable model of sexual plasticity with a conserved neural mechanism.Significance StatementSexual plasticity, adapting reproductive behaviors to social changes, was explored in the fruit fly, a genetically tractable model insect. Findings revealed that inseminated females, encountering another courting male post-mating, shorten the ejaculate holding period (EHP). Specific olfactory and gustatory pathways regulating this phenomenon were identified, converging on the pC1 neurons in the brain-a conserved neural circuit regulating female mating activity. Odors associated with EHP shortening increased the second messenger cAMP. The elevated cAMP transiently heightened the excitability of pC1 neurons, enabling inseminated females to promptly remove the male ejaculate and engage in the subsequent mating more readily. This study establishes a behavioral model for sexual plasticity and provide a framework for understanding the involved neural processes.

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Predatory aggression evolved through adaptations to noradrenergic circuits

Eren,

Böger,

Roca

et al. 2024

Preprint

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Behaviors are adaptive traits evolving through natural selection. Crucially, the genetic, molecular, and neural modifications that shape behavioral innovations are poorly understood. Here, we identify specialized adaptations linked to the evolution of aggression in the predatory nematodePristionchus pacificus. Using machine learning, we identified robust behavioral states associated with aggressive episodes. These depend on modifications to the invertebrate noradrenergic pathway, with octopamine promoting predatory bouts, and tyramine antagonistically suppressing predation. Strikingly, aggression coincides with rewiring of key circuits across nematode evolution. We find additional octopaminergic neurons with morphological adaptations, including neurites extending to teeth-like structures, and expanded receptor expression throughout head sensory neurons gating prey detection. Thus, evolutionary adaptations in noradrenergic circuits facilitated the emergence of aggressive behavioral states associated with complex predatory traits.

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Mating pair drives aggressive behavior in female Drosophila

Cited by 6 publications

References 64 publications

Fighting Flies: Quantifying and AnalyzingDrosophilaAggression

Fighting Flies: Quantifying and AnalyzingDrosophilaAggression

Male cuticular pheromones stimulate removal of the mating plug and promote re-mating through pC1 neurons inDrosophilafemales

Predatory aggression evolved through adaptations to noradrenergic circuits

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