The optimal parameters for the degradation of pure terephthalic acid (PTA) wastewater by the white rot fungus Phanerochaete chrysosporium were investigated. The relative mathematical model, objective function equation, constraint equations, constraint conditions and computer program were established in the optimal method. The results showed that the optimal value of the reactor volume needed was 9798 m 3 . It could save 83.82% of the reactor volume, which was needed for the native bacterium YZ1. This optimal method is simple, useful and economical for average treatment plants. Using the optimal parameters and P. chrysosporium to design and operate the treatment process of PTA wastewater would increase the treatment efficiency and decrease the cost.