Mathematical Modelling of Non‐Linear Solvent‐Gradient Simulated Moving Bed Chromatographic Separation Processes

Evaluation of the New Phi-Plot Modeling Approach Optimization by Stepwise Solvent Gradient Simulated Moving Bed (SG-SMB) Simulator

“…Such procedures usually increase the purity of products as well as the productivity, reducing solvent consumption. The application of gradients can be used in the performance improvement of simulated moving bed (SMB) as well as true moving bed (TMB) chromatography in which the most usual is the solvent-gradient method applied to SMB processes [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Other techniques include temperature gradients in SMB [16], micellar gradients in size-exclusion SMB [17], salt gradients in size-exchange SMB [18], pressure gradient in supercritical eluent SMB [19], voltage gradients in true moving bed (TMB) electrophoresis [20], etc.…”