Mathematical modeling unveils the timeline of CAR-T cell therapy and macrophage-mediated cytokine release syndrome
Daniela S. Santurio,
Luciana R. C. Barros,
Ingmar Glauche
et al.
Abstract:Chimeric antigen receptor (CAR)-T cell therapy holds significant potential for cancer treatment, although disease recurrence and cytokine release syndrome (CRS) remain as frequent clinical challenges. To better understand the underlying mechanisms and temporal dynamics during CAR-T cell therapy response we developed a novel multi-layer mathematical model that accurately describes 25 patient time-courses with diverse responses and IL-6 cytokine kinetics. We successfully link the dynamic shape of the response to… Show more
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