Abstract:The release of extractables from multi‐layered plastic films such as those used in containers for liquid drug products has been investigated. Targeted extractables were chosen from the film's extractable profile, as elucidated by a controlled extraction study. The total available pool of targeted extractables was ascertained via exhaustive sequential extraction of the film and the film layer responsible for the target extractables was established. This information, along with the film's structure, was used to … Show more
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