A transient mathematical model is developed to study the transient response and analyze the distribution of heat load in a loop heat pipe. The model is based on the one-dimensional and time-dependent conservation equations for heat and fluid flow. The momentum and energy conservation equations for each of the loop heat pipe components are solved. The model results are compared against the data obtained from two miniature loop heat pipes using polytetrafluoroethylene wicks, ethanol, and acetone as working fluids. The mathematical model satisfactorily predicts the dynamic behavior of the loop heat pipe unit. It is shown that the percentage of heat leak across the wick decreases and the ratio of latent heat increases with increasing heat load. Some temperature overshoots observed in the calculation results are not observed in the experimental data. When a new power is applied, no time lag is observed in the loop heat pipe response between the simulation and experimental results. Nomenclature A = cross section area, m 2 A s = surface area, m 2 C = heat capacity, J∕kg c = constant in Chisholm correlation c p = specific heat at constant pressure, J∕kg K D = diameter, m f = Darcy's friction coefficient G A B = thermal conductance between A and B, W∕K Gr = Grashof number g = gravity, m∕s 2 h = heat transfer coefficient, W∕m 2 K h lat = latent heat, J∕kg k = thermal conductivity, W∕m K L = length, m _ m = mass flow rate, kg∕s Nu = Nusselt number Pr = Prandtl number p = pressure, Pa _ Q A B = rate of heat transfer from A to B, W _ Q apply = heat load, W q = amount of heat transfer per volume, W∕m 3 Re = Reynolds number T = temperature,°C u = velocity, m∕s V = volume, m 3 X = ratio between vapor and liquid frictional pressure loss Greek β = coefficient of volume expansion, 1∕K ε = porosity ν = kinematic viscosity coefficient, m 2 ∕s ρ = density, kg∕m 3 τ w = wall shear stress, Pa Φ i = square root of ratio between the frictional pressure loss in single phase i and two-phase flow Subscript amb = ambient bay = bayonet tube cc = compensation chamber e = evaporator eff = effective fc = forced convection gr = groove hb = heater block int = interface l = liquid nc = natural convection sat = saturation sub = subcooled v = vapor 2f = two phase