Mathematical modeling of insulin sorption by ion‐exchange fiber

Medovic, Adela; Škundrić, Petar; Pajić‐Lijaković, Ivana; Kostić, Mirjana

doi:10.1002/app.25578

Cited by 6 publications

(6 citation statements)

References 14 publications

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“…Also, our former research [17][18][19] was oriented towards mastering a procedure for obtaining a biologically active, complex "ion-exchange fiber-insulin", as an artificial insulin depot and as a basis for medical treatment of insulin dependent diabeticals. For such needs, a cation-exchange polyacrilonytrile fiber saponified with sodium metasilicate has been developed.…”

Section: Introductionmentioning

confidence: 99%

Oxidized cotton as a substrate for the preparation of hormone-active fibers-characterization, efficiency and biocompatibility

et al. 2015

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Oxidized cellulose has a long history of safe and effective use in medical applications. In this paper, research has been directed towards obtaining hormone-active cellulose fibers in the form of an artificial insulin depot, and examination of its biocompatibility regarding cytotoxicity, sensitization, and irritation. The procedure of obtaining the fibrous insulin depot is based on the modification of cotton fibers with sodium periodate, followed by chemisorption of insulin from insulin aqueous solutions. In order to optimize the insulin chemisorption process, the influence of the fiber structure parameters, i.e. the aldehyde group content and iodine sorption value (ISV) on the chemisorption capacity was examined. The obtained artificial depot, containing ≈55 mg insulin/g of fibers, has been characterized in vitro by investigation of the desorption kinetics of the insulin from the fibrous depot. It has been shown that insulin is controllably released in quantities of 1.3-1.6 mg of insulin during 24 hours, in the course of 20 days. The results of biocompatibility tests have shown that the examined artificial depot neither shows irritating effects nor provokes sensitizing or cytotoxic effects. Therefore, these materials are acceptable for use in a direct contact with tissue of a living organism.

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Section: Introductionmentioning

confidence: 99%

Oxidized cotton as a substrate for the preparation of hormone-active fibers-characterization, efficiency and biocompatibility

et al. 2015

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“…[45][46][47][48][49][50] Usually, the drug-loaded ion exchangers are compressed into tablets, 16,51 suspended in liquids, 17,30,34 filled in the capsules, [52][53][54][55][56] used individually as powders, 15,31,32 suspended in matrices (such as gels 20,36 , gums 57 ), and incorporate into the implant formulations. 58 The detailed usage of ion exchangers is just like active pharmaceutical ingredients during the formulation preparation, only the drug-loaded ion exchangers are insoluble in water or oil. The drug in the ion exchangers will be released to play efficacy when contact with the ions in the body.…”

Section: Introductionmentioning

confidence: 99%

Loading and Release of Amine Drugs by Ion-Exchange Fibers: Role of Amine Type

Gao

Liu

Yuan

et al. 2014

Journal of Pharmaceutical Sciences

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“…The chemisorption process of insulin of ion-exchanged fibers, depends directly on the type and forms of fibrous, static ion-exchange capacity, concentration of insulin solution, pH value, temperature and duration of the contact between insulin and fiber, bath modulus, etc that have been shown in ours previous experimental research. [6][7][8][9] 2. Materials and Methods…”

Section: Introductionmentioning

confidence: 99%

Development of Hormone-Active Fiber in the Form of Artificial Insulin Depot

Baralic¹,

Škundrić²,

Sretkovic³

et al. 2012

ENG

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This study examines the phenomena of the hormone-active fibers obtaining process, in the form of artificial insulin depot. As a fibrous carrier of insulin cation-exchange polyacrylonitrile (PAN) fibers and biodegradable polysaccharide alginate fibers were used. The process of obtaining fibrous artificial insulin depot was based on the chemisorption of insulin from insulin aqueous solutions by these fibers. The parameters of insulin chemisorption reaction were determined and their influence on quantities of bonded insulin in the artificial depot was studied. The impact of fiber polymer nature on the intensity of insulin chemisorption was studied and determined. Also, the location and deposition of insulin in and onto the fiber, fiber topography were studied. The maximum amounts of bounded insulin for the cation-exchange PAN fibers were 395.0 mg porcine insulin chromatographic / g of fiber, and for the alginate fibers were about 300 mg of porcine insulin chromatographic / g of fiber.

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Mathematical modeling of insulin sorption by ion‐exchange fiber

Cited by 6 publications

References 14 publications

Oxidized cotton as a substrate for the preparation of hormone-active fibers-characterization, efficiency and biocompatibility

Oxidized cotton as a substrate for the preparation of hormone-active fibers-characterization, efficiency and biocompatibility

Loading and Release of Amine Drugs by Ion-Exchange Fibers: Role of Amine Type

Development of Hormone-Active Fiber in the Form of Artificial Insulin Depot

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