Mathematical modeling of alveolar clearance of chrysotile asbestos fibers from the rat lungs

Yu, C.P.; Asgharian, Bahman; Abraham, Joanna

doi:10.1016/0021-8502(90)90134-j

Cited by 9 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The data from the RCC studies of RCFs have been used in the model of pulmonary deposition, retention and clearance developed by Yu et al [37][38][39][40][41]. It appears that the estimated MTD was too high and pulmonary 'overload' occurred.…”

Section: Uses Of Mineral Fibresmentioning

confidence: 99%

Man-Made Mineral Fibres: Hazard, Risk and Regulation

Brown

1994

Indoor Environment

View full text Add to dashboard Cite

Exposure to asbestos dust can cause fibrosis and/or cancer of the lungs or pleura. Experiments have confirmed that this can occur in animals exposed to a variety of non-asbestos fibres. The man-made vitreous fibres are manufactured and used in vast quantities and the possibility that they pose some hazard has attracted particular attention. No epidemiological studies have caused concern over the health effects of these materials and there are reasons to believe that the animal experiments overestimate their hazard. This is particularly true when fibres are injected or implanted into the body cavities. Many regulatory agencies are attempting to devise regulations covering hazard labelling or risk reduction but none are yet scientifically satisfactory. Both the European Union and the German authorities have attempted to devise classification schemes based partly on the ability of fibres to persist in tissue but the more sophisticated German approach is flawed as it takes no account of many factors affecting solubility and relies on injection experiments to modify the classification generated by a crude composition index.

show abstract