Mathematical modeling for Delta and Omicron variant of SARS-CoV-2 transmission dynamics in Greece

Liossi, Sofia; Tsiambas, E.; Maipas, S.; Papageorgiou, E.; Lazaris, A.; Kavantzas, N.

doi:10.1016/j.idm.2023.07.002

Cited by 8 publications

(5 citation statements)

References 59 publications

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“…According to Six et al and Alay et al, circulating levels of Angiopoietin-2 as a marker of endothelial injury were higher in hospitalized patients with COVID-19 than in healthy controls [6,24]. Also, the study by Smadja et al indicated that Angiopoietin-2 is a relevant predictive factor for ICU direct admission in COVID-19 patients [25].…”

Section: Discussionmentioning

confidence: 98%

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Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves

Tsiatsiou,

Kouirouxis,

Tsaireli

et al. 2024

CIMB

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This study aimed to explore the correlation between Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) concentrations and the Angiopoietin-2/Angiopoietin-1 ratio (Ang-2/Ang-1) with clinical outcomes, potentially serving as disease severity and survival biomarkers. A study at AHEPA University Hospital involved 90 Coronavirus Disease 2019 (COVID-19) adult patients, 30 hospitalized intensive care units (ICU), 30 inward units (non-ICU), and 30 asymptomatic non-hospitalized individuals as controls. Estimated endothelial dysfunction markers related to angiogenesis were measured. There was a statistically significant difference only between outpatient and hospitalized patients (non-ICU–ICU groups) for the Ang-1 and Ang-2 indices. The Ang-2/Ang-1 ratio has differed significantly among the individual patient groups. An ROC analysis was conducted to find an optimal threshold for distinguishing between (outpatients–non-ICU) and (non-ICU–ICU) groups. It was based on Youden’s index of 0.1122 and 0.3825, respectively. The Ang-1, Ang-2 levels, and Ang-2/Ang-1 ratio were analyzed as severity indicators in COVID-19 patients. The Ang-2/Ang-1 ratio demonstrated better prognostic and diagnostic utility than individual biomarker levels. Monitoring the Ang-2/Ang-1 ratio can identify COVID-19 patients at risk and assist clinicians in tailoring treatment strategies to improve outcomes.

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Section: Discussionmentioning

confidence: 98%

“…Despite its milder severity, the Omicron variant is more contagious than the Delta variant [4,5]. During this period, immunity was based on protection from prior vaccination and infection [6].…”

Section: Introductionmentioning

confidence: 99%

Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves

Tsiatsiou,

Kouirouxis,

Tsaireli

et al. 2024

CIMB

View full text Add to dashboard Cite

show abstract

“…Despite the disease's milder severity, the Omicron variant is more contagious than the Delta variant [6,7]. In this period, immunity was based on protection due to prior vaccination and infection [8].…”

Section: Introductionmentioning

confidence: 99%

Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves

Tsiatsiou,

Kouirouxis,

Tsaireli

et al. 2024

Preprint

View full text Add to dashboard Cite

The study aimed to explore the correlation among Angiopoietin-1, (Ang-1) and Angiopoietin-2, (Ang-2) concentrations and the Angiopoietin-2/Angiopoietin-1 ratio, (Ang-2/Ang-1) with clinical outcomes, potentially serving as disease severity and survival biomarkers. A study at AHEPA University Hospital involved 90 COVID-19 adult patients, with 30 hospitalized in intensive care and 30 in ward units and 30 asymptomatic non-hospitalized individuals as controls. Estimated endothelial dysfunction markers related to angiogenesis were measured, and statistical analysis was performed using IBM SPSS Statistics software, version 29. There was a statistically significant difference only between outpatient and hospitalized patients (non-ICU -ICU groups) for the Ang-1 and Ang-2 indexes. The Ang-2/Ang-1 ratio has differed significantly among all individual patient groups. A ROC analysis was conducted to find an optimal threshold for distinguishing (outpatients – non-ICU) and (non-ICU –ICU) groups. It was based on Youden's Index and was 0.1122 and 0.3825, respectively. The Ang-1, Ang-2 levels, and Ang-2/Ang-1 ratio were analysed as indicators for severity in COVID-19 patients. The Ang-2/Ang-1 ratio demonstrated more excellent prognostic and diagnostic utility than individual biomarker levels. Monitoring the Ang-2/Ang-1 ratio can identify COVID-19 patients at risk and assist clinicians in tailoring treatment strategies for improved outcomes.

show abstract

“…Despite the disease's milder 2 severity, the Omicron variant is more contagious than the Delta variant [5,6]. In this period immunity was based on protection due to prior vaccination and infection [7].…”

Section: Introductionmentioning

confidence: 99%

Angiopoietins as Predictor Indexes in COVID COVID-19 Patients in Delta and Omicron Waves

Tsiatsiou,

Kouirouxis,

Tsaireli

et al. 2023

Preprint

View full text Add to dashboard Cite

The study aimed to explore the correlation among angiopoietin-1, (Ang-1) and Angiopoietin-2, (Ang-2) concentrations and the Angiopoietin-2/Angiopoietin-1 ratio, (Ang-2/Ang-1) with clinical outcomes, potentially serving as disease severity and survival biomarkers. A study at AHEPA University Hospital involved 90 COVID-19 adult patients, with 30 hospitalized in intensive care and 30 in ward units and 30 asymptomatic non-hospitalized individuals as controls. Estimated endothelial dysfunction markers related to angiogenesis were measured, and statistical analysis was performed using IBM SPSS Statistics software, version 29. There was a statistically significant difference only between outpatient and hospitalized patients (non-ICU -ICU groups) for the Ang-1 and Ang-2 indexes. The Ang-2/Ang-1 ratio has differed significantly among all individual patient groups. A ROC analysis was conducted to find an optimal threshold for distinguishing (outpatients – non-ICU) and (non-ICU – ICU) groups. It was based on Youden's Index and was 0.1122 or 0.1271 and 0.3825 or 0.4510, respectively. The Ang-1, Ang-2 levels, and Ang-2 / Ang-1 ratio were analysed as indicators for severity in COVID-19 patients. The Ang-2 / Ang-1 ratio demonstrated more excellent prognostic and diagnostic utility than individual biomarker levels. Monitoring the Ang-2/Ang-1 ratio can identify COVID-19 patients at risk and assist clinicians in tailoring treatment strategies for improved outcomes.

show abstract

Mathematical modeling for Delta and Omicron variant of SARS-CoV-2 transmission dynamics in Greece

Cited by 8 publications

References 59 publications

Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves

Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves

Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves

Angiopoietins as Predictor Indexes in COVID COVID-19 Patients in Delta and Omicron Waves

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