Mathematical Modeling and Simulations for Developing Nanoparticle-Based Cancer Drug Delivery Systems: A Review

Sahai, Nitin; Gogoi, Manashjit; Ahmad, Nabeel

doi:10.1007/s40139-020-00219-5

Cited by 26 publications

(10 citation statements)

References 69 publications

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“…Nanotechnology has made great impacts in recent advances in all the major technological areas including biomedical engineering, food science, IT, etc. [10][11][12][13][14][15][16][17][18][19]. For precision agriculture, agrochemicals prepared in different formats of nanomaterials promise a variety of appealing characteristics, including controlled and stimulation-regulated release rate, location-or time-specific targeting, long-term stability and duration, increased solubility, enhanced compatibility, etc.…”

Section: Introductionmentioning

confidence: 99%

Recent development in functional nanomaterials for sustainable and smart agricultural chemical technologies

2022

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New advances in nanotechnology are driving a wave of technology revolution impacting a broad range of areas in agricultural production. The current work reviews nanopesticides, nano-fabricated fertilizers, and nano activity-based growth promoters reported in the last several years, focusing on mechanisms revealed for preparation and functioning. It appears to us that with many fundamental concepts have been demonstrated over last two decades, new advances in this area continue to expand mainly in three directions, i.e., efficiency improvement, material sustainability and environment-specific stimulation functionalities. It is also evident that environmental and health concerns associated with nano agrochemicals are the primary motivation and focus for most recent work. Challenges and perspectives for future development of nano agrochemicals are also discussed.

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Section: Introductionmentioning

confidence: 99%

Recent development in functional nanomaterials for sustainable and smart agricultural chemical technologies

2022

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“…Not only in cancer but also in endothelial biology, it is very crucial to evaluate the uptake of drug conjugated nanoparticles by the blood brain barrier (BBB) that can effectively cross the latter with minimal to no side effects [ 16 ]. These along with mathematical modeling and simulation studies have enabled the researchers to achieve significant strides in comprehending alteration in signaling mechanisms, cellular morphology and linear nanomechanical properties (NMPs) that include membrane stiffness, deformation and adhesion using atomic force microscope (AFM) [ 17 – 22 ]. Cell is largely composed of cytosolic fluid and is susceptible to both external and internal biomechanical stimuli, which triggers signaling pathways such as intracellular signal transduction, PI3K/AKT and kinase signalling that corresponds to the cell proliferation, differentiation and apoptosis [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Dynamic alteration of poroelastic attributes as determinant membrane nanorheology for endocytosis of organ specific targeted gold nanoparticles

2022

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Background Efficacy of targeted drug delivery using nanoparticles relies on several factors including the uptake mechanisms such as phagocytosis, macropinocytosis, micropinocytosis and receptor mediated endocytosis. These mechanisms have been studied with respect to the alteration in signaling mechanisms, cellular morphology, and linear nanomechanical properties (NMPs). Commonly employed classical contact mechanics models to address cellular NMPs fail to address mesh like structure consisting of bilayer lipids and proteins of cell membrane. To overcome this technical challenge, we employed poroelastic model which accounts for the biphasic nature of cells including their porous behavior exhibiting both solid like (fluid storage) and liquid like (fluid dissipate) behavior. Results In this study, we employed atomic force microscopy to monitor the influence of surface engineering of gold nanoparticles (GNPs) to the alteration of nonlinear NMPs such as drained Poisson’s ratio, effective shear stress, diffusion constant and pore dimensions of cell membranes during their uptake. Herein, we used pancreatic cancer (PDAC) cell lines including Panc1, AsPC-1 and endothelial cell (HUVECs) to understand the receptor-dependent and -independent endocytosis of two different GNPs derived using plectin-1 targeting peptide (PTP-GNP) and corresponding scrambled peptide (sPEP-GNP). Compared to untreated cells, in case of receptor dependent endocytosis of PTP-GNPs diffusion coefficient altered ~ 1264-fold and ~ 1530-fold and pore size altered ~ 320-fold and ~ 260-fold in Panc1 and AsPC-1 cells, respectively. Whereas for receptor independent mechanisms, we observed modest alteration in diffusion coefficient and pore size, in these cells compared to untreated cells. Effective shear stress corresponding to 7.38 ± 0.15 kPa and 20.49 ± 0.39 kPa in PTP-GNP treatment in Panc1 and AsPC-1, respectively was significantly more than that for sPEP-GNP. These results demonstrate that with temporal recruitment of plectin-1 during receptor mediated endocytosis affects the poroelastic attributes of the membrane. Conclusion This study confirms that nonlinear NMPs of cell membrane are directly associated with the uptake mechanism of nanoparticles and can provide promising insights of the nature of endocytosis mechanism involved for organ specific drug delivery using nanoparticles. Hence, nanomechanical analysis of cell membrane using this noninvasive, label-free and live-cell analytical tool can therefore be instrumental to evaluate therapeutic benefit of nanoformulations. Graphical Abstract

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“…Currently, various nanoscale agents, such as, noble metals (Ag, Au) [ 10 , 11 ], mesoporous silica [ 12 ], liposomes [ 13 ], polymers [ 14 ] and their hybrids, have been systematically investigated and have drawn increasing attention because they offer several favorable properties in the fields of drug delivery, tissue engineering, imaging sensors, etc. [ 15 , 16 ]. However, these nanoparticles (NPs) with particle sizes ranging from 50 to 500 nm are mostly internalized via endocytosis and trapped in recycling endosomes (pH 5.5–6.5) [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Amplified antitumor efficacy by a targeted drug retention and chemosensitization strategy-based “combo” nanoagent together with PD-L1 blockade in reversing multidrug resistance

Jiang

Meng

et al. 2021

J Nanobiotechnol

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Background Recent studies have demonstrated that multidrug resistance (MDR) is a critical factor in the low efficacy of cancer chemotherapy. The main mechanism of MDR arises from the overexpression of P-glycoprotein (P-gp), which actively enhances drug efflux and limits the effectiveness of chemotherapeutic agents. Results In this study, we fabricated a “combo” nanoagent equipping with triple synergistic strategies for enhancing antitumor efficacy against MDR cells. Tumor homing-penetrating peptide endows the nanosystem with targeting and penetrating capabilities in the first stage of tumor internalization. The abundant amine groups of polyethylenimine (PEI)-modified nanoparticles then trigger a proton sponge effect to promote endo/lysosomal escape, which enhances the intracellular accumulation and retention of anticancer drugs. Furthermore, copper tetrakis(4-carboxyphenyl)porphyrin (CuTCPP) encapsulated in the nanosystem, effectively scavenges endogenous glutathione (GSH) to reduce the detoxification mediated by GSH and sensitize the cancer cells to drugs, while simultaneously serving as a photoacoustic imaging (PAI) contrast agent for image visualization. Moreover, we also verify that these versatile nanoparticles in combination with PD-1/PD-L1 blockade therapy can not only activate immunological responses but also inhibit P-gp expression to obliterate primary and metastatic tumors. Conclusion This work shows a significant enhancement in therapeutic efficacy against MDR cells and syngeneic tumors by using multiple MDR reversing strategies compared to an equivalent dose of free paclitaxel. Graphic Abstract

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Mathematical Modeling and Simulations for Developing Nanoparticle-Based Cancer Drug Delivery Systems: A Review

Cited by 26 publications

References 69 publications

Recent development in functional nanomaterials for sustainable and smart agricultural chemical technologies

Recent development in functional nanomaterials for sustainable and smart agricultural chemical technologies

Dynamic alteration of poroelastic attributes as determinant membrane nanorheology for endocytosis of organ specific targeted gold nanoparticles

Amplified antitumor efficacy by a targeted drug retention and chemosensitization strategy-based “combo” nanoagent together with PD-L1 blockade in reversing multidrug resistance

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