2023
DOI: 10.3390/math11184017
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Mathematical Model to Predict Polyclonal T-Cell-Dependent Antibody Synthesis Responses

Jagdish Thakur,
Archana Thakur,
Lawrence Lum

Abstract: Mathematical models are becoming indispensable tools to explore the complexities of biological systems at cellular levels. We present a model to explore the baseline immune cell interactions for in vitro polyclonal antibody synthesis via B-cells regulated by helper and regulatory T-cells. The model incorporates interactions of antigen-presenting cells, T-cells, regulatory T-cells, and B-cells with each other and predicts time-dependent trajectories of these cells and antibody synthesis stimulated by pokeweed m… Show more

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