Mathematical Model for Malaria Disease Transmission

Abstract

Malaria is one of the fatal diseases caused by plasmodium parasites and transmitted to humans through biting of the female of {\it Anopheles} mosquitoes. We proposed a deterministic mathematical model for simulating Malaria disease transmission between humans and mosquitoes. The basic reproduction number $\mathcal{R}_{0}$ is determined by using the next-generation matrix approach. Stability conditions for the model equilibrium points with respect to $\mathcal{R}_{0}$ derived and we show that the forward bifurcation occurred. When $\mathcal{R}_{0} <1$ or $\mathcal{R}_{0} >1$ the Malaria disease dies out or spreads, respectively. The sensitivity analysis for the basic reproduction number $\mathcal{R}_{0}$ fulfilled locally and globally. The model simulation was found by using Runge--Kutta fourth order method in MATLAB. Furthermore, The effects of the important parameters were investigated, and the obtained results were presented in graphical forms. Also, we obtained that the simulation results agree with the stability analysis for $E_{def}$. We discussed the impacts of the Malaria disease control interventions on the important parameter for Malaria disease transmission. Recommendation for control and eradicating Malaria disease transmission provided.