Mathematical formulae for the prediction of the residual beta cell function during the first two years of disease in children and adolescents with insulin-dependent diabetes mellitus

Klipper-Aurbach, Yaffa; Wasserman, M; Braunspiegel-Weintrob, N.; Borstein, D.; Peleg, Sagit; Assa, S.; Karp, M; Benjamini, Yoav; Hochberg, Yosef; Laron, Zvi

doi:10.1016/0306-9877(95)90228-7

Cited by 229 publications

(185 citation statements)

References 23 publications

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“…Overrepresented PlantGOslim categories were identified using a hypergeometric test with a significance threshold of 0.05 for gene clusters and of 0.5 for organ-specific genes, after Benjamini and Hochberg false discovery rate correction (Klipper-Aurbach et al, 1995).…”

Section: Functional Category Distribution and Go Enrichment Analysismentioning

confidence: 99%

The Grapevine Expression Atlas Reveals a Deep Transcriptome Shift Driving the Entire Plant into a Maturation Program

et al. 2012

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We developed a genome-wide transcriptomic atlas of grapevine (Vitis vinifera) based on 54 samples representing green and woody tissues and organs at different developmental stages as well as specialized tissues such as pollen and senescent leaves. Together, these samples expressed ;91% of the predicted grapevine genes. Pollen and senescent leaves had unique transcriptomes reflecting their specialized functions and physiological status. However, microarray and RNA-seq analysis grouped all the other samples into two major classes based on maturity rather than organ identity, namely, the vegetative/ green and mature/woody categories. This division represents a fundamental transcriptomic reprogramming during the maturation process and was highlighted by three statistical approaches identifying the transcriptional relationships among samples (correlation analysis), putative biomarkers (O2PLS-DA approach), and sets of strongly and consistently expressed genes that define groups (topics) of similar samples (biclustering analysis). Gene coexpression analysis indicated that the mature/woody developmental program results from the reiterative coactivation of pathways that are largely inactive in vegetative/green tissues, often involving the coregulation of clusters of neighboring genes and global regulation based on codon preference. This global transcriptomic reprogramming during maturation has not been observed in herbaceous annual species and may be a defining characteristic of perennial woody plants.

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Section: Functional Category Distribution and Go Enrichment Analysismentioning

confidence: 99%

The Grapevine Expression Atlas Reveals a Deep Transcriptome Shift Driving the Entire Plant into a Maturation Program

et al. 2012

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“…P-values are adjusted to Q-values for multiple testing corrections by 2 alternative strategies. 57,58 Monocyte adhesion assay Monocyte adhesion assay was carried out as described previously with some modifications. 59 HUVECs in 12-well plates were treated with scramble or ANRIL siRNA for 24 h, followed by incubation with or without TNF-a (25 ng/mL) for another 6 h. U937 cells were then added for 1 h. Unbound cells were removed by gentle washing, and the number of U937 cells attached to HUVECs was counted under a phase-contrast microscope (Olympus).…”

Section: Rna Sequencingmentioning

confidence: 99%

Long non-coding RNA ANRIL regulates inflammatory responses as a novel component of NF-κB pathway

et al. 2015

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Antisense Noncoding RNA in the INK4 Locus (ANRIL) is the prime candidate gene at Chr9p21, the welldefined genetic risk locus associated with multiple human diseases including coronary artery disease (CAD), while little is known regarding its role in the pathological processes. Endothelial dysfunction triggers atherosclerotic processes that are causatively linked to CAD. To evaluate the function of ANRIL in human endothelial cells (ECs), we examined ANRIL expression under pathological stimuli and found ANRIL was markedly induced by pro-inflammatory factors. Loss-of-function and chromatin immunoprecipitation approaches revealed that NF-kB mediates TNF-a induced ANRIL expression. RNA sequencing revealed that ANRIL silencing dysregulated expression of inflammatory genes including IL6 and IL8 under TNF-a treatment. We explored the regulatory mechanism of ANRIL on IL6/8 and found that Yin Yang 1 (YY1), an ANRIL binding transcriptional factor revealed by RNA immunoprecipitation, was required for IL6/8 expression under TNF-a treatment. YY1 was enriched at promoter loci of IL6/8 and ANRIL silencing impaired the enrichment, indicating a cooperation between ANRIL and YY1 in the regulation of inflammatory genes. For the first time, we establish the connection between ANRIL and NF-kB pathway and show that ANRIL regulates inflammatory responses through binding with YY1. The newly identified TNF-a-NF-kB-ANRIL/YY1-IL6/8 pathway enhances understanding of the etiology of CAD and provides potential therapeutic target for treatment of CAD.

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“…p-values less than 0.001 with a fold change in expression of 2 are considered to be statistically significant. The Benjamini-Hochberg 41 method was used to estimate the false discovery rate (FDR) for the significant gene list. …”

Section: 31mentioning

confidence: 99%

Slug (SNAI2) expression in oral SCC cells results in altered cell-cell adhesion and increased motility

Katafiasz

Smith

Wahl³

2011

Cell Adhesion & Migration

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Mathematical formulae for the prediction of the residual beta cell function during the first two years of disease in children and adolescents with insulin-dependent diabetes mellitus

Cited by 229 publications

References 23 publications

The Grapevine Expression Atlas Reveals a Deep Transcriptome Shift Driving the Entire Plant into a Maturation Program

The Grapevine Expression Atlas Reveals a Deep Transcriptome Shift Driving the Entire Plant into a Maturation Program

Long non-coding RNA ANRIL regulates inflammatory responses as a novel component of NF-κB pathway

Slug (SNAI2) expression in oral SCC cells results in altered cell-cell adhesion and increased motility

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