Mathematical filtration of quaternary mixture to the zero order spectra of its individual components

Fahmy, Nesma M.; Hesham, Khaled; Tawakkol, Shereen M.; Abdel‐Aziz, Lobna M.; Abdelrahman, Mona H.

doi:10.1016/j.saa.2021.119999

Cited by 2 publications

(1 citation statement)

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“…Unfortunately, multicomponent mixtures, including this studied mixture, typically have highly overlapping spectra, which urged the buildup of various methods for determining each studied drug's concentration [ 25 ]. Recent incorporated spectrophotometer software that supports mathematical techniques is believed to be an optimal key to resolve complicated spectra, and to get as much analytical data as possible from the unresolved bands [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Utilizing two different sustainable and green spectrophotometric approaches using derivative ratio spectra for the determination of a ternary severely overlapped mixture: application to veterinary formulation

Abdullatif,

Abdelkawy,

Kamal

et al. 2024

BMC Chemistry

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Mathematical manipulation technique has proven to be a very powerful tool for efficient processing and handling of highly overlapped spectra. This work introduced two green and sustainable approaches for the successful recovery of the ternary mixture, Tylosin tartarate (TYL), Sulfadimdine (SLD), and Trimethoprim (TRI). The approaches were constructed using three different methods, derivative ratio spectrum zero-crossing method (DRSZ), double divisor ratio spectra derivative method (DDRD), and factorized derivative ratio method coupled with spectrum subtraction (FDRM-SS). The two approaches succeeded in recovering the three drugs (Linearity range achieved were 0.5–5 µg/mL for TYL, 0.3–1.3 µg/mL for SLD, and 0.3–5 µg/mL for TRI), giving convenient standard deviations and satisfactory recovery percentages. The recommended methods have been verified in accordance with (ICH) guidelines. When the results were statistically compared to the official methods, no significant difference was found. Both AGREE—Analytical GREEnness Metric Approach and Software, and White Analytical Chemistry (WAC) RGB model gave scores of 0.93 and 97.2%, respectively, which proved that the approaches were eco-friendly and abiding by the sustainability principles.

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Section: Introductionmentioning

confidence: 99%