Mathematical description of synergistic interaction of hyperthermia and lonizing radiation

Петин, В.Г.; Komarov, V.P.

doi:10.1016/s0025-5564(97)00078-3

Cited by 16 publications

(2 citation statements)

References 30 publications

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“…Specifically, they combine by addition, with this being disguised by the intervention of the function f . Factors that combine in some other way, such as via the minimum, as in a weakest link theory, fall outside the scope of this model: an example is in Petin and Komarov (1997). There is no guarantee that such a model will be a good fit to data, but it is worth investigating.…”

Section: Additivity Plus Nonlinearitymentioning

confidence: 99%

Beyond Interaction: Theories

Hutchinson

2006

Qual Quant

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Section: Additivity Plus Nonlinearitymentioning

confidence: 99%

Beyond Interaction: Theories

Hutchinson

2006

Qual Quant

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“…We were the first to apply PEF to intracerebrally implanted RG2 tumors, combined with bleomycin, which resulted in a significantly (p < 0.001) prolonged survival of the rats (9). PEF has been also been employed in vivo by a number of other groups to introduce anticancer agents into various experimental tumors (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

A Model for Evaluating Therapeutic Response of Combined Cancer Treatment Modalities: Applied to Treatment of Subcutaneously Implanted Brain Tumors (N32 and N29) in Fischer Rats with Pulsed Electric Fields (PEF) and ⁶⁰ Co-gamma Radiation (RT)

Persson

Koch

Grafström

et al. 2003

Technol Cancer Res Treat

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The aim of the present study is to develop a mathematical model for evaluating therapeutic response of combined treatment modalities. The study was performed in rats of the Fischer-344 strain with rat glioma N32 or N29 tumors implanted subcutaneously on the thigh of the hind leg. Pulsed electric fields, PEF, with 16 exponentially decaying pulses with a maximum electric field strength of 140 V/mm and t 1/e = 1 ms were first applied to the tumors. Then within 5 min radiation therapy with 60 Co-gamma radiation, RT, was given in daily fractions of 5 Gy. The animals were arranged into one group of controls and 3 groups of different kind of treatments: PEF only, RT only or combination of PEF + RT. At about 4 weeks after inoculation, the tumors were given the treatment sessions during one week.In 2 experimental series with totally 52 rats with N32 tumors, of which 16 were controls, were given 4 sessions of PEF treatments and RT (totally 20 Gy). In a special experimental series with totally 56 rats with N32 tumors, of which 10 were controls, the different groups were given 1, 2, 3 or 4 treatment sessions respectively. Another strain of glioma tumor, N29 with 62 tumors of which 14 were controls was studied in 2 series given 4PEF + 4RT and 2PEF + 4RT respectively. This work demonstrate the use of our model for analyzing the combination PEF + RT, but it can also be used for evaluation the therapeutic effects of combining RT with chemotherapy or immunogene-therapy.

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Arrhenius thermodynamics and birth defects: Chemical teratogen synergy. Untested, testable, and projected relevance

Miller

Church²

2013

Birth Defects Research Pt C

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This article addresses the issue of hyperthermia-induced birth defects with an accompanying additional teratogen, be it a chemical or a physical agent (i.e., a simultaneous "combinational" exposure to two teratogens, one of which is hyperthermia). Hyperthermia per se is a recognized human and animal teratogen. An excellent example of such combinational exposures is an epileptic woman who becomes pregnant while taking valproic acid (VPA) to control seizures. VPA is a recognized chemical teratogen, and fever (hyperthermia) is not an uncommon event during pregnancy. While VPA also may occasionally induce fever as a side effect, we are concerned here with fevers arising from other, unrelated causes. There is a small but internally consistent literature on these combinational-teratogen exposures involving hyperthermia plus a chemical teratogen; in each instance, the effect level has been observed to be synergistically elevated above levels induced by the separate teratogenic components. The data were empirical. The observed synergy is, however, consistent with Arrhenius thermodynamics, a well-known chemical rate equation. The need for information about combinational teratogen exposures is acute; fever is a common occurrence during pregnancy; and there are many instances whereby there is also the simultaneous presence of some other teratogen(s). Given that the rate of autism spectrum disorders in the United States was recently presented as 1 in 88 births, it seems reasonable to suspect that such combinational regimens are much more prevalent than previously thought. Our hypothesis is that synergistic birth defect levels from combinational regimens are consistent with Arrhenius thermodynamics.

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Mathematical description of synergistic interaction of hyperthermia and lonizing radiation

Cited by 16 publications

References 30 publications

Beyond Interaction: Theories

Beyond Interaction: Theories

A Model for Evaluating Therapeutic Response of Combined Cancer Treatment Modalities: Applied to Treatment of Subcutaneously Implanted Brain Tumors (N32 and N29) in Fischer Rats with Pulsed Electric Fields (PEF) and ⁶⁰ Co-gamma Radiation (RT)

Arrhenius thermodynamics and birth defects: Chemical teratogen synergy. Untested, testable, and projected relevance

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Mathematical description of synergistic interaction of hyperthermia and lonizing radiation

Cited by 16 publications

References 30 publications

Beyond Interaction: Theories

Beyond Interaction: Theories

A Model for Evaluating Therapeutic Response of Combined Cancer Treatment Modalities: Applied to Treatment of Subcutaneously Implanted Brain Tumors (N32 and N29) in Fischer Rats with Pulsed Electric Fields (PEF) and 60 Co-gamma Radiation (RT)

Arrhenius thermodynamics and birth defects: Chemical teratogen synergy. Untested, testable, and projected relevance

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A Model for Evaluating Therapeutic Response of Combined Cancer Treatment Modalities: Applied to Treatment of Subcutaneously Implanted Brain Tumors (N32 and N29) in Fischer Rats with Pulsed Electric Fields (PEF) and ⁶⁰ Co-gamma Radiation (RT)