Mathematical Assessment of the Role of Three Factors Entangled in the Development of Glaucoma by Means of the Ocular Mathematical Virtual Simulator

Sala, Lorenzo; Prud'Homme, Christophe; Guidoboni, Giovanna; Szopos, Marcela; Harris, Alon

doi:10.1007/978-3-030-55874-1_84

Cited by 3 publications

(9 citation statements)

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“…Compartmental models have been used to investigate the relationships between intravascular and extravascular pressures and haemodynamics in the retina and choroid [64,93,120,205,226,233,254,256]. In these models, similar vessels are sorted into compartments, e.g.…”

Section: Effects Of Extravascular Pressure On Haemodynamicsmentioning

confidence: 99%

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Advancing treatment of retinal disease through in silico trials

2023

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Treating retinal diseases to prevent sight loss is an increasingly important challenge. Thanks to the configuration of the eye, the retina can be examined relatively easily in situ. Owing to recent technological development in scanning devices, much progress has been made in understanding the structure of the retina and characterising retinal biomarkers. However, treatment options remain limited and are often of low efficiency and efficacy.In recent years, the concept of in silico clinical trials has been adopted by many pharmaceutical companies to optimise and accelerate the development of therapeutics. In silico clinical trials rely on the use of mathematical models based on the physical and biochemical mechanisms underpinning a biological system. With appropriate simplifications and assumptions, one can generate computer simulations of various treatment regimens, new therapeutic molecules, delivery strategies and so forth, rapidly and at a fraction of the cost required for the equivalent experiments. Such simulations have the potential not only to hasten the development of therapies and strategies but also tooptimise the use of existing therapeutics.In this paper, we review the state-of-the-art in in silico models of the retina for mathematicians, biomedical scientists and clinicians, highlighting the challenges to developing in silico clinical trials. Throughout this paper, we highlight key findings from in silico models about the physiology of the retina in health and disease. We describe the main building blocks of in silico clinical trials and identify challenges to developing in silico clinical trials of retinal diseases.

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Section: Effects Of Extravascular Pressure On Haemodynamicsmentioning

confidence: 99%

“…Numerous models have been developed to explain alterations of blood flow observed in eyes presenting with those pathologies [65,119,252,254]. Elevated IOP, a hallmark of glaucoma, is expected to affect the retinal circulation, causing loss of sight.…”

Section: Models Of Glaucoma and Vessel Occlusionmentioning

confidence: 99%

Advancing treatment of retinal disease through in silico trials

2023

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“…The proposed results provide an extensive validation of the model, that paves the way for its utilization in the context of clinical research for glaucoma. By comprehensively modeling the lamina cribrosa's and the surrounding tissues behavior under varying conditions, 16,17,91,100 our framework could aid in predicting and understanding the hemodynamical and biomechanical changes associated with glaucomatous damage. This, in turn, may contribute to improved diagnostic and treatment strategies, enhancing patient care.…”

Section: Biomechanics Of Cornea Sclera Choroid and Retinamentioning

confidence: 99%

“…In this section we discuss several significant outcomes of the OMVS and compare our simulations with clinical or experimental data whenever available. The aim is to provide a thorough validation for the OMVS framework and to complement predictive results previously published in References 17,80, The verification of the numerical methods presented in Section 3 has been already extensively performed in Reference 15.…”

Section: Omvs Validationmentioning

confidence: 99%

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The ocular mathematical virtual simulator: A validated multiscale model for hemodynamics and biomechanics in the human eye

Sala,

Prud'homme,

Guidoboni

et al. 2023

Numer Methods Biomed Eng

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We present our continuous efforts from a modeling and numerical viewpoint to develop a powerful and flexible mathematical and computational framework called Ocular Mathematical Virtual Simulator (OMVS). The OMVS aims to solve problems arising in biomechanics and hemodynamics within the human eye. We discuss our contribution towards improving the reliability and reproducibility of computational studies by performing a thorough validation of the numerical predictions against experimental data. The OMVS proved capable of simulating complex multiphysics and multiscale scenarios motivated by the study of glaucoma. Furthermore, its modular design allows the continuous integration of new models and methods as the research moves forward, and supports the utilization of the OMVS as a promising non‐invasive clinical investigation tool for personalized research in ophthalmology.

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