Maternal zinc deficiency and congenital anomalies in newborns

Moghimi, Mahmood; Ashrafzadeh, Sahar; Rassi, Sepehr; Naseh, Ali

doi:10.1111/ped.13176

Cited by 13 publications

(6 citation statements)

References 22 publications

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“…Sever and Emmanuel 24 claimed that maternal zinc deficiency was related to congenital malformations of the central nervous system. Moghimi et al 25 conducted a case–control study in Iran involving mothers of 80 neonates with congenital anomalies. They also found an association between congenital malformation in newborns and maternal zinc deficiency.…”

Section: Discussionmentioning

confidence: 99%

Maternal and neonatal micronutrient levels in newborns with CHD

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Maternal and neonatal micronutrient levels in newborns with CHD

et al. 2018

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“…Moreover, zinc content was restored after zinc supplementation in the maternal diet. It has been reported that zinc deficiency during pregnancy is associated with increased risks of fetal malformation, including neural tube defects (Moghimi et al, 2017;Brion et al, 2021). Previous animal studies reported that prenatal caffeine consumption could induce altered sleep and locomotion, anxiety, and learning abilities, in addition, it may interfere with brain zinc absorption (Cortés-Albornoz et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

In utero exposure of green coffee extract alters rat fetal neurodevelopment in a dose dependent manner

Atallah

El-Gaber

2022

Journal of Bioscience and Applied Research

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Green coffee consumption has gained wide popularity, possibly due to its strong antioxidative activities and many beneficial effects in various human diseases. However, the effect of green coffee extract consumption on the development of the fetal central nervous system during pregnancy has not been elucidated. Consequently, the present study aimed to evaluate the effect of maternal administration of some doses of the green coffee extract on the development of the cerebral cortex, cerebellum, and spinal cord of rat fetuses in terms of histopathological, proliferation, astrogliosis, and ultrastructural investigations. Pregnant dams were divided into four groups; control group (administered distilled water) and three groups orally administered three different doses of green coffee extract, GC1 (200 mg/kg), GC2 (400 mg/kg), and GC3 (600 mg/kg) from the sixth day to the 15 th day of gestation.On the 20 th day, dams were sacrificed and fetal cerebral cortex, cerebellum, and spinal cord from different groups were fixed for subsequent investigations. The results showed that green coffee extract induced various histopathological changes in the three investigated organs including pyknosis, hemorrhage, and vacuolation.Immunohistochemical investigation revealed that green coffee extract decreased neuronal proliferation and increased reactive astrogliosis. Ultrastructurally, green coffee extract caused cytoplasmic rarefaction, neuronal degeneration, macrophage activation, and axon degeneration. Interestingly, the neurotoxic effects of green coffee on neuronal development were dose-dependent. Based on these results, the consumption of high doses of green coffee during pregnancy should be restricted. Moreover, further studies are needed to evaluate the long-term effects of green coffee ingestion on neuronal cognition and behavioral outcomes.

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“…This is consistent with what is observed in humans, as maternal Zn deficiency during pregnancy in humans increases the risk of fetal growth restriction [70], with a clear association between maternal Zn level during pregnancy and the risks of low birth weight and small gestation age infants (Figure 2). Additional studies on human populations have confirmed the effect of maternal Zn deficiency on growth retardation [71,72], but have also uncovered congenital abnormalities [73], immune system failures [74,75], reproductive defects [76,77], and more generally an increased susceptibility to complex pathologies [46,47]. Unfortunately, studies conducted on humans are intrinsically descriptive and those focusing on molecular impact of Zn on development are rare.…”

Section: Impact Of Zn Deficiency On Early Embryonic Developmentmentioning

confidence: 99%

Impact of Zinc Transport Mechanisms on Embryonic and Brain Development

Willekens

Runnels

2022

Nutrients

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The trace element zinc (Zn) binds to over ten percent of proteins in eukaryotic cells. Zn flexible chemistry allows it to regulate the activity of hundreds of enzymes and influence scores of metabolic processes in cells throughout the body. Deficiency of Zn in humans has a profound effect on development and in adults later in life, particularly in the brain, where Zn deficiency is linked to several neurological disorders. In this review, we will summarize the importance of Zn during development through a description of the outcomes of both genetic and early dietary Zn deficiency, focusing on the pathological consequences on the whole body and brain. The epidemiology and the symptomology of Zn deficiency in humans will be described, including the most studied inherited Zn deficiency disease, Acrodermatitis enteropathica. In addition, we will give an overview of the different forms and animal models of Zn deficiency, as well as the 24 Zn transporters, distributed into two families: the ZIPs and the ZnTs, which control the balance of Zn throughout the body. Lastly, we will describe the TRPM7 ion channel, which was recently shown to contribute to intestinal Zn absorption and has its own significant impact on early embryonic development.

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Maternal zinc deficiency and congenital anomalies in newborns

Abstract: There is an association between congenital malformation in newborns and maternal zinc deficiency.

Cited by 13 publications

References 22 publications

Maternal and neonatal micronutrient levels in newborns with CHD

Maternal and neonatal micronutrient levels in newborns with CHD

In utero exposure of green coffee extract alters rat fetal neurodevelopment in a dose dependent manner

Impact of Zinc Transport Mechanisms on Embryonic and Brain Development

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