Maternal weight in pregnancy and offspring body composition in late adulthood: Findings from the Helsinki Birth Cohort Study (HBCS)

Eriksson, Johan G.; Sandboge, Samuel; Salonen, Minna K.; Kajantie, Eero; Osmond, Clive

doi:10.3109/07853890.2015.1004360

Cited by 118 publications

(86 citation statements)

References 31 publications

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Section: Discussioncontrasting

confidence: 64%

“…Maternal BMI has been associated with less favorable body compositions in later adulthood among the offspring, as well as with CAD, type 2 diabetes mellitus, stroke, and cancer. 19,20 We did not find the association to be influenced by intermediate hypertension, CAD, or type 2 diabetes mellitus, but we have not been able to adjust for adult body composition. Besides genetic and epigenetic factors, BMI could also be inherited in families through cultural factors resulting in women with high BMI transmitting habits to their offspring that result in high adult BMI.…”

Section: Maternal Factors and Afmentioning

confidence: 67%

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Early Life Risk Factors for Incident Atrial Fibrillation in the Helsinki Birth Cohort Study

Johnson

Salonen

Kajantie

et al. 2017

JAHA

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BackgroundEarly life risk factors are associated with cardiometabolic disease, but have not been fully studied in atrial fibrillation (AF). There are discordant results from existing studies of birth weight and AF, and the impact of maternal body size, gestational age, placental size, and birth length is unknown.Methods and ResultsThe Helsinki Birth Cohort Study includes 13 345 people born as singletons in Helsinki in the years 1934–1944. Follow‐up was through national registries, and ended on December 31, 2013, with 907 incident cases. Cox regression analyses stratified on year of birth were constructed for perinatal variables and incident AF, adjusting for offspring sex, gestational age, and socioeconomic status at birth. There was a significant U‐shaped association between birth weight and AF (P for quadratic term=0.01). The lowest risk of AF was found among those with a birth weight of 3.4 kg (3.8 kg for women [85th percentile] and 3.0 kg for men [17th percentile]). High maternal body mass index (≥30 kg/m2) predicted offspring AF; hazard ratio 1.36 (95% CI 1.07–1.74, P=0.01) compared with normal body mass index (<25 kg/m2). Maternal height was associated with early‐onset AF (<65.3 years), hazard ratio 1.47 (95% CI 1.24–1.74, P<0.0001), but not with later onset AF. Results were independent of incident coronary artery disease, hypertension, or diabetes mellitus.ConclusionsHigh maternal body mass index during pregnancy and maternal height are previously undescribed predictors of offspring AF. Efforts to prevent maternal obesity might reduce later AF in offspring. Birth weight has a U‐shaped relation to incident AF independent of other perinatal variables.

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Section: Discussioncontrasting

confidence: 64%

Section: Maternal Factors and Afmentioning

confidence: 67%

Early Life Risk Factors for Incident Atrial Fibrillation in the Helsinki Birth Cohort Study

Johnson

Salonen

Kajantie

et al. 2017

JAHA

Self Cite

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“…These studies were originally considered under the umbrella term of 'the fetal origins of adult disease' (FOAD), as the major focus was on the role of the intrauterine environment on later offspring outcomes, but the concept was later extended to include other aspects of developmental plasticity, including the early post-natal period and possible preconceptual and intergenerational influences. Since the initial papers were published, low birth weight has also been shown to be associated with offspring obesity (Eriksson et al, 2015), depression (Van Lieshout and Boylan, 2010) and intelligence (Eryigit Madzwamuse et al, 2014). However, studies to date have for the most part been conducted using observational data; therefore, while they provide suggestive evidence that these developmental influences affect later outcomes, they are limited in terms of providing strong enough evidence that a causal interpretation can be drawn.…”

Section: Introductionmentioning

confidence: 99%

Causal Inference in Developmental Origins of Health and Disease (DOHaD) Research

Gage

Munafò

Smith

2016

Annu. Rev. Psychol.

153

152

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Studies of the developmental origins of health and disease (DOHaD) often rely on prospective observational data, from which associations between developmental exposures and outcomes in later life can be identified. Typically, conventional statistical methods are used in an attempt to mitigate problems inherent in observational data, such as confounding and reverse causality, but these have serious limitations. In this review, we discuss a variety of methods that are increasingly being used in observational epidemiological studies to help strengthen causal inference. These methods include negative controls, cross-contextual designs, instrumental variables (including Mendelian randomization), family-based studies, and natural experiments. Applications within the DOHaD framework, and in relation to behavioral, psychiatric, and psychological domains, are considered, and the considerable potential for expanding the use of these methods is outlined.

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“…Experimental and clinical evidence arising from research into the developmental origins of health and disease (DoHAD) suggests that maternal obesity also has long-lasting consequences on the health of the offspring. It is now established that maternal obesity is associated with increased body-mass index (BMI) of offspring across infancy [9], adolescence [10], and into adulthood [11,12]. Obesity during gestation is also linked with increased risk of coronary heart disease, diabetes, stroke, asthma, and premature death in adult offspring [13,14,15].…”

Section: Introductionmentioning

confidence: 99%

A Review of the Impact of Maternal Obesity on the Cognitive Function and Mental Health of the Offspring

Contu

Hawkes

2017

IJMS

123

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Globally, more than 20% of women of reproductive age are currently estimated to be obese. Children born to obese mothers are at higher risk of developing obesity, coronary heart disease, diabetes, stroke, and asthma in adulthood. Increasing clinical and experimental evidence suggests that maternal obesity also affects the health and function of the offspring brain across the lifespan. This review summarizes the current findings from human and animal studies that detail the impact of maternal obesity on aspects of learning, memory, motivation, affective disorders, attention-deficit hyperactivity disorder, autism spectrum disorders, and neurodegeneration in the offspring. Epigenetic mechanisms that may contribute to this mother–child interaction are also discussed.

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Maternal weight in pregnancy and offspring body composition in late adulthood: Findings from the Helsinki Birth Cohort Study (HBCS)

Cited by 118 publications

References 31 publications

Early Life Risk Factors for Incident Atrial Fibrillation in the Helsinki Birth Cohort Study

Early Life Risk Factors for Incident Atrial Fibrillation in the Helsinki Birth Cohort Study

Causal Inference in Developmental Origins of Health and Disease (DOHaD) Research

A Review of the Impact of Maternal Obesity on the Cognitive Function and Mental Health of the Offspring

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