Maternal vitamin D status in relation to infant BMI growth trajectories up to 2 years of age in two prospective pregnancy cohorts

Amberntsson, Anna; Bärebring, Linnea; Winkvist, Anna; Lissner, Lauren; Meltzer, Helle Margrete; Brantsæter, Anne‐Lise; Papadopoulou, Eleni; Augustin, Hanna

doi:10.1002/osp4.602

Cited by 4 publications

(6 citation statements)

References 49 publications

(101 reference statements)

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“…Genetic‐level studies have suggested that the genotype GC rs7041 modifies the effects of pregnancy on maternal and placental metabolism of vitamin D, with possible functional consequences for fetal bone development and childhood health 38 . A Scandinavian study (59‐60° N) found that maternal vitamin D deficiency was predictive of a higher infant body mass index growth trajectory, a finding that was significant only for women with lower levels of vitamin D 39 . A multicenter study in Spain, however, did not find a relationship between vitamin D deficiency and the risk of being overweight in fetuses, newborns, and infants aged up to one year 25 …”

Section: Resultsmentioning

confidence: 99%

The Effects of Latitude and Temperate Weather on Vitamin D Deficiency and Women's Reproductive Health: A Scoping Review

Vergara‐Maldonado,

Urdaneta‐Machado

2023

J Midwife Womens Health

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Introduction We conducted a scoping review to analyze the effects and implications of vitamin D deficiency on female reproductive health during the last decade, considering temperate planetary zones and climate change impacts. Methods We used a qualitative methodology for a panoramic database review of PubMed, Web of Science, and Scopus covering articles from the last decade focused on populations living at latitudes higher than 40° N and 40° S. As descriptors, we used the phrases climate change, cholecalciferol or vitamin d3, pregnancy, and woman health and the Boolean operators AND and OR. We excluded letters to the editor, reviews, protocols, and clinical trials without human participants, as well as duplicate articles. Results We included 35 studies in English, the majority of which were from North America or Europe. No studies were found from the Southern Hemisphere or having any direct relation with climate change, although studies demonstrated that latitude and environmental factors affected vitamin D deficiency, which had an impact on pregnant women and their children. Supplementation guidelines were not well developed, and there was a lack of studies among at‐risk groups of women (eg, darker skin, higher latitudes, immigrants) across the life span. Discussion Vitamin D deficiency is a global environmental problem that affects female reproductive health and depends on multiple environmental factors and human behavior. Therefore, we recommend consideration of environmental and sociocultural factors in public policy and clinical research and more research on the effectiveness of supplementation and fortification strategies. Health care professionals working in reproductive health need to generate actions for detection of, education on, and prevention of vitamin D deficiency among women across their life spans, considering the multicausality of the phenomenon, which includes environmental and climate factors in population health.

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Section: Resultsmentioning

confidence: 99%

The Effects of Latitude and Temperate Weather on Vitamin D Deficiency and Women's Reproductive Health: A Scoping Review

Vergara‐Maldonado,

Urdaneta‐Machado

2023

J Midwife Womens Health

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“…There has been controversy as to whether maternal vitamin D status has implications for the risk of offspring adiposity. We have previously seen that lower maternal 25OHD was associated with a higher BMI growth trajectory class during the first 2 years of life ( 18 ), possibly affecting the child’s health beyond infancy. The novelty of the current paper includes investigation of the association between maternal 25OHD and the child’s BMI and overweight at 5 years of age.…”

Section: Discussionmentioning

confidence: 99%

“…The blood sample drawn before gestational week 17 was used in the GraviD cohort. Additionally, the vitamin D Standardization Program protocol, compensating for assay variability, was applied in the GraviD study as previously described ( 18 ).…”

Section: Methodsmentioning

confidence: 99%

“…Maternal vitamin D status in pregnancy has also been associated with childhood growth and adiposity ( 17 ). For example, we previously found that maternal 25OHD ≤75 nmol/L was associated with a higher body mass index (BMI) growth trajectory class during the first 2 years of life ( 18 ). Several other observational studies have investigated the association between maternal vitamin D status during pregnancy and different outcome measures of childhood adiposity, at various ages, but the results are inconclusive ( 19–22 ).…”

Section: Introductionmentioning

confidence: 99%

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Maternal vitamin D status and risk of childhood overweight at 5 years of age in two Nordic cohort studies

et al. 2023

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IntroductionMaternal vitamin D status during pregnancy has been suggested to have a role in childhood adiposity development, but results are conflicting. Our aims were to investigate [1] the relationships between maternal 25-hydroxyvitamin D (25OHD) during pregnancy and the child’s body mass index (BMI) and risk of overweight at 5 years of age, and [2] maternal pre-pregnancy BMI as effect modifier for these associations.MethodsData sources included a subsample from the Norwegian Mother, Father and Child Cohort Study (MoBa sub-cohort; N = 2,744) and the Swedish GraviD cohort study (N = 891). Maternal 25OHD was analyzed in gestational week 18 in the MoBa sub-cohort and week 10 in the GraviD cohort. In the MoBa sub-cohort, parents reported their child’s documented measures of weight and length or height from the health card at routine check-up. In the GraviD cohort, this information was collected directly from medical records. Childhood overweight (including obesity) was identified using the International Obesity Task Force cut-offs. Linear and logistic regression models were used to investigate the association between maternal 25OHD and child’s BMI and risk of overweight at 5 years of age in each cohort separately, and in a pooled dataset.ResultsIn the pooled analysis, maternal 25OHD <30 nmol/L was associated with lower BMI in children at 5 years of age, but not with risk of overweight. Interaction analysis showed that the association was predominant among children of mothers with pre-pregnancy BMI ≥25 kg/m2.ConclusionLow maternal vitamin D status, particularly in mothers with overweight or obesity, predicted lower BMI in their five-year-old children. However, there was no evidence of an effect on overweight in these children.

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“…

In Amberntsson et al, 1 there was some incorrect information regarding the analyses of 25-hydroxyvitamin D in the Section 2.3

Blood sample analysis.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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mentioning

confidence: 99%

Correction to “Maternal vitamin D status in relation to infant BMI growth trajectories up to 2 years of age in two prospective pregnancy cohorts”

2023

Obesity Science & Practice

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Maternal vitamin D status in relation to infant BMI growth trajectories up to 2 years of age in two prospective pregnancy cohorts

Cited by 4 publications

References 49 publications

The Effects of Latitude and Temperate Weather on Vitamin D Deficiency and Women's Reproductive Health: A Scoping Review

The Effects of Latitude and Temperate Weather on Vitamin D Deficiency and Women's Reproductive Health: A Scoping Review

Maternal vitamin D status and risk of childhood overweight at 5 years of age in two Nordic cohort studies

Correction to “Maternal vitamin D status in relation to infant BMI growth trajectories up to 2 years of age in two prospective pregnancy cohorts”

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