Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study

Javaid, M K; Crozier, Sarah; Harvey, Nicholas C.; Gale, Catharine R.; Dennison, Elaine; Boucher, Barbara J.; Arden, N K; Godfrey, Keith M.; Cooper, Cyrus

doi:10.1016/s0140-6736(06)67922-1

Cited by 694 publications

(451 citation statements)

References 31 publications

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“…Subsequently, the Endocrine Society issued slightly different guidelines, defining vitamin D insufficiency as being serum 25(OH) D levels below 30 ng/mL (75 nM) (Holick et al 2011). Against this backdrop, several recent publications have highlighted the prevalence of low serum concentrations of 25(OH)D (less than 25 nM) in pregnant women: 20% of pregnant women in the UK (Javaid et al 2006), 25% in the UAE (Dawodu et al 1997), 80% in Iran (Bassir et al 2001, 45% in northern India (Sachan et al 2005), 60% in New Zealand (Eagleton & Judkins 2006) and 60-84% of pregnant non-Western women in the Netherlands (van der Meer et al 2006). It remains unclear if this reflects simply a normal physiological drop in vitamin D concentrations during pregnancy or if pregnancy is a stress test that can exacerbate and unmask pathological vitamin D deficiency.…”

Section: Vitamin D and Trophoblast Function: Clinical Implicationsmentioning

confidence: 99%

“…These include preeclampsia (Bodnar et al 2007b), fetal growth restriction, small-for-gestational-age fetus (Bodnar et al 2010), bacterial vaginosis (Bodnar et al 2009) and gestational diabetes mellitus (Maghbooli et al 2008, Zhang et al 2008. Maternal vitamin D deficiency has also been linked to adverse effects in offspring, including reduced bone density (Javaid et al 2006) and childhood rickets (Wagner & Greer 2008), as well as increased risk of asthma (Camargo et al 2007) and schizophrenia (McGrath 2001).…”

Section: Vitamin D and Trophoblast Function: Clinical Implicationsmentioning

confidence: 99%

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Vitamin D, the placenta and early pregnancy: effects on trophoblast function

Ganguly

Tamblyn

Finn-Sell

et al. 2018

Journal of Endocrinology

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Pregnancy is associated with significant changes in vitamin D metabolism, notably increased maternal serum levels of active vitamin D, 1,25-dihydroxyvitamin (1,25(OH) 2 D). This appears to be due primarily to increased renal activity of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) that catalyzes synthesis of 1,25(OH) 2 D, but CYP27B1 expression is also prominent in both the maternal decidua and fetal trophoblast components of the placenta. The precise function of placental synthesis of 1,25(OH) 2 D remains unclear, but is likely to involve localized tissue-specific responses with both decidua and trophoblast also expressing the vitamin D receptor (VDR) for 1,25(OH) 2 D. We have previously described immunomodulatory responses to 1,25(OH) 2 D by diverse populations of VDR-expressing cells within the decidua. The aim of the current review is to detail the role of vitamin D in pregnancy from a trophoblast perspective, with particular emphasis on the potential role of 1,25(OH) 2 D as a regulator of trophoblast invasion in early pregnancy. Vitamin D deficiency is common in pregnant women, and a wide range of studies have linked low vitamin D status to adverse events in pregnancy. To date, most of these studies have focused on adverse events later in pregnancy, but the current review will explore the potential impact of vitamin D on early pregnancy, and how this may influence implantation and miscarriage.

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Section: Vitamin D and Trophoblast Function: Clinical Implicationsmentioning

confidence: 99%

Section: Vitamin D and Trophoblast Function: Clinical Implicationsmentioning

confidence: 99%

Vitamin D, the placenta and early pregnancy: effects on trophoblast function

Ganguly

Tamblyn

Finn-Sell

et al. 2018

Journal of Endocrinology

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“…Changes in fetal femoral development with maternal vitamin D insufficiency can be observed as early as 19-week gestation using 3D ultrasound (Mahon et al 2010) and such changes in bone structure may occur well into early childhood (Javaid et al 2006). Although vitamin D may have a role in fetal skeletal development, other dominant pregnancy hormones such as prolactin, estradiol and lactogen are also key to this process (Kirby et al 2013).…”

Section: Vitamin D Deficiency and Placental Development And Functionmentioning

confidence: 99%

“…There is evidence that the increased maternal intestinal calcium absorption that occurs in pregnancy and calcium supply to the fetus is regulated by mechanisms independent of the typical vitamin D pathway. Thus, maternal vitamin D deficiency is associated with reduced fetal cord blood calcium and bone mineralization in some (Cockburn et al 1980, Maghbooli et al 2007), but not all (Javaid et al 2006) studies. Indeed, a systematic review of vitamin D supplementation in pregnancy found limited evidence for an association between maternal vitamin D status and offspring birthweight, bone mass or serum calcium concentrations (Harvey et al 2014).…”

Section: Vitamin D Deficiency and Placental Development And Functionmentioning

confidence: 99%

Vitamin D deficiency and impaired placental function: potential regulation by glucocorticoids?

Yates¹,

Crew²,

Wyrwoll³

2017

Reproduction

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Maternal vitamin D deficiency has been implicated in a range of pregnancy complications including preeclampsia, preterm birth and intrauterine growth restriction. Some of these adverse outcomes arise from alterations in placental function. Indeed, vitamin D appears critical for implantation, inflammation, immune function and angiogenesis in the placenta. Despite these associations, absence of the placental vitamin D receptor in mice provokes little effect. Thus, interactions between maternal and fetal compartments are likely crucial for instigating adverse placental changes. Indeed, maternal vitamin D deficiency elicits changes in glucocorticoid-related parameters in pregnancy, which increase placental and fetal glucocorticoid exposure. As in utero glucocorticoid excess has a well-established role in eliciting placental dysfunction and fetal growth restriction, this review proposes that glucocorticoids are an important consideration when understanding the impact of vitamin D deficiency on placental function and fetal development.Reproduction (2017) 153 R163-R171

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“…In a longitudinal study of 198 children in the UK, reduced 25(OH)D levels in their mothers during late pregnancy was associated with reduced whole-body (r = 0.21, p = 0.009) and lumbar spine (r = 0.17, p = 0.03) bone mineral content in children at age 9 years [15]. This may in part be explained by some data from observational studies [16,17,18,19] and small clinical trials [20,21] suggesting that a higher vitamin D status among pregnant women correlates positively with the birth weight of their offspring, although some observational studies showed a neutral association [22,23,24,25,26].…”

Section: Why Is It Important To Avoid Vitamin D Deficiency In Pregnanmentioning

confidence: 99%

Vitamin D – Role in Pregnancy and Early Childhood

Bischoff‐Ferrari¹

2011

Ann Nutr Metab

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Several studies in pregnant women and early childhood suggest that vitamin D deficiency (serum 25-hydroxyvitamin D levels <50 nmol/l) is common in both population groups. Recent recommendations have therefore reviewed the literature regarding the role of vitamin D in pregnant women and in early childhood. The Institute of Medicine, in their most recent assessment in 2010, recommended 600 IU per day in pregnant and lactating women. In 2011, the US Endocrine Task Force on Vitamin D commented that 600 IU per day may not be sufficient to correct vitamin D deficiency in pregnant and lactating women. Their recommendation was 1,500–2,000 IU vitamin D per day in pregnant and lactating women with vitamin D deficiency. For infants, the recommendation from both societies is consistently 400 IU vitamin D per day, and also in children both societies recommend 600 IU vitamin D per day. This review will summarize the scientific basis that led to the most recent recommendations.

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Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study

Cited by 694 publications

References 31 publications

Vitamin D, the placenta and early pregnancy: effects on trophoblast function

Vitamin D, the placenta and early pregnancy: effects on trophoblast function

Vitamin D deficiency and impaired placental function: potential regulation by glucocorticoids?

Vitamin D – Role in Pregnancy and Early Childhood

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