Maternal vitamin D deficiency associated with neonatal hypocalcaemic convulsions

Camadoo, Laxmi; Tibbott, Rebecca; Isaza, Fernando

doi:10.1186/1475-2891-6-23

Cited by 59 publications

(42 citation statements)

References 6 publications

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“…With Previous studies demonstrate relation between vitamin D deficiency and various medical disorders like depression, type 1 diabetes, Syndrome X, as well as chronic widespread muscle and bone pain [6][7][8][9][10]. And even in infancy it causes rickets and hypocalcemic fits [11,12].…”

Section: Introductionmentioning

confidence: 99%

Awareness of Vitamin D and its Deficiency in Jeddah Population, Saudi Arabia

Agha¹,

Alorabi²

2016

J Comm Pub Health Nursing

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Introduction: Vitamin D deficiency considered to be the most common nutritional deficiency and one of the most common undiagnosed medical conditions in the world. It appears to be a widespread global problem prevalent in all age groups, with a reported prevalence of 30-80% in children and adults This significant decreased in vitamin D level worldwide in different age group shows lack of awareness about vitamin D importance and its resources.

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Section: Introductionmentioning

confidence: 99%

Awareness of Vitamin D and its Deficiency in Jeddah Population, Saudi Arabia

Agha¹,

Alorabi²

2016

J Comm Pub Health Nursing

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“…Congenital rickets and neonatal hypocalcemic seizures are the early neonatal findings of maternal vitamin D deficiency (1,2). In mothers with low vitamin D levels, in addition to the classical findings of vitamin D deficiency, the risks of preeclampsia, gestational diabetes, prematurity, and infants small for gestational age have been found to be high (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Incidence of maternal vitamin D deficiency in a region of Ankara, Turkey: a preliminary study

GÜR¹,

Abacı²,

KÖKSOY³

et al. 2014

Turk J Med Sci

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A greenhouse experiment was conducted to observe the effects of Bacillus megaterium strain TV-91C, Pantoea agglomerans strain RK-92, and B. subtilis strain TV-17C inoculation on the growth, nutrient, and hormone content of cabbage seedlings. The seeds of cabbage were incubated in flasks by shaking at 80 rpm for 2 h at 28 °C to coat the seeds with the rhizobacteria. Plant growth-promoting rhizobacteria (PGPR) treatments increased fresh and dry shoot and root weight, stem diameter, seedling height, chlorophyll reading values, and leaf area of cabbage seedlings compared with the control. Among the strains, B. megaterium TV-91C gave the greatest seedling nutrient content and growth parameters, although the maximum values for leaf area, gibberellic acid, salicylic acid, and indole acetic acid (IAA) contents of seedlings were obtained with the P. agglomerans RK-92 treatment. Seed inoculation with B. megaterium TV-91C increased fresh and dry shoot and root weight by 32.9%, 22.6%, 16.0%, and 35.69%, respectively. Inoculations also increased the stem diameter, seedling height, and SPAD chlorophyll values by 47.5%, 27.2%, and 5.8%, respectively. Furthermore, compared to the control, P. agglomerans RK-92 increased gibberellic acid, salicylic acid, IAA, and leaf area by 13.9%, 70.9%, 38.5%, and 27.3%, respectively. PGPR treatments may improve seedling growth and quality in cabbages.

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“…Vitamin D deficiency in neonates secondary to vitamin D deficiency in their mothers is not uncommon and may lead to hypocalcemia as vitamin D plays crucial role in calcium homeostasis (Camadoo, 2007). Maternal vitamin D deficiency results in poor transplacental transfer of vitamin D during pregnancy and reduced stores in the newborns.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Hypocalcemic Convulsions Secondary to Vitamin D Deficiency

Azzoug¹,

Bekkaye

Chentli³

et al. 2017

ijccr

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Vitamin D deficiency is a major public health issue affecting large proportions of the population. Therefore, maternal vitamin D deficiency is not uncommon. Infants born to mothers who are deficient in vitamin D are at risk of developing vitamin D deficiency and hypocalcaemia. We reported here a case of neonatal hypocalcaemic seizures secondary to vitamin D deficiency. A 25-day old, full term male infant presented two episodes of generalized seizures. Laboratory investigations in blood, revealed low calcium level at 5.5 mg/dl, elevated phosphatemia level at 9.6 mg/dl and high parathormone (PTH) level at 133.4 pg/ml. Unfortunately 25 hydroxy vitamin D assay was not available in the infant but it was low in the mother at 12.9 ng/ml. The infant was commenced on vitamin D and calcium supplements during some weeks which allowed normalization of calcium levels. After several months of treatment cessation, the infant was doing well, and his development was according to his chronological age. His calcium, phosphatemia and PTH levels were within normal ranges without any treatment. Hypocalcemia in this infant was presumably due to vitamin D deficiency as other causes were unlikely. Neonatal hypocalcaemic seizures are a rare presentation of vitamin D deficiency. This case could have been preventable had the mother been given vitamin D supplementation during pregnancy and early lactation.

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Maternal vitamin D deficiency associated with neonatal hypocalcaemic convulsions

Cited by 59 publications

References 6 publications

Awareness of Vitamin D and its Deficiency in Jeddah Population, Saudi Arabia

Awareness of Vitamin D and its Deficiency in Jeddah Population, Saudi Arabia

Incidence of maternal vitamin D deficiency in a region of Ankara, Turkey: a preliminary study

Neonatal Hypocalcemic Convulsions Secondary to Vitamin D Deficiency

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