Maternal vitamin D and growth of under-five children: a systematic review and meta-analysis of observational and interventional studies

Tareke, Amare Abera; Alem, Addis; Debebe, Wondwosen; Bayileyegn, Nebiyou Simegnew; Abebe, Melese Shenkut; Abdu, Hussen; Zerfu, Taddese Alemu

doi:10.1080/16549716.2022.2102712

Cited by 4 publications

(2 citation statements)

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“…Thus, blood 25OHD levels reflect vitamin D status from both diet and sunlight exposure. 7 Numerous studies have confirmed associations between HT and trace elements such as iodine and selenium; 8–11 however, the association between HT and vitamin D remains debatable. A recent review proposed that vitamin D deficiency may contribute to the pathophysiology, hypothyroidism, and autoimmunity of HT.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Efficacy and Mechanism of Vitamin D2 in Treating Hashimoto’s Thyroiditis

Gan,

2024

JIR

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Objective Hashimoto’s thyroiditis (HT) is one of the most common autoimmune diseases, with the highest incidence rate among autoimmune thyroid disorders. Vitamin D2 may have therapeutic effects on HT. This study aimed to elucidate the molecular mechanisms underlying vitamin D2 therapy for HT. Methods Differentially expressed genes (DEGs) associated with vitamin D2-treated HT were identified, and the DEG-associated gene enrichment pathway was explored using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. The correlation between the hub genes and infiltrating immune cells was investigated, and the interactions among the hub genes and target drug and competing endogenous RNA (ceRNA; long non-coding RNA [lncRNA]–microRNA [miRNA]–messenger RNA [mRNA]) regulatory networks were determined. Results GO and KEGG enrichment analyses identified a total of 102 DEGs (6 upregulated and 96 downregulated) in the vitamin D2-treated group samples. The area under the curve values of the identified 10 hub genes was as follows: CCR1(0.920), CXCL1 (0.960), CXCL8 (0.960), EGR1 (0.960), FCGR3B (0.920), FOS (1.000), FPR1 (0.840), MMP9 (0.720), PTGS2 (0.960), and TREM1 (1.000). The immune enrichment scores of the mast cell (P = 0.008), neutrophil (P = 0.016), and plasmacytoid dendritic cell (P = 0.016) were significantly decreased in the vitamin D2-treated group (P < 0.05). The hub gene/drug regulatory network included 8 hub genes, 108 molecular drugs, and 114 interaction relationship pairs. The ceRNA regulatory network included 129 lncRNAs, 145 miRNAs, mRNAs (hub genes), and 324 interaction relationship pairs. Conclusion Vitamin D2 may play an immunomodulatory role by regulating the aforementioned immune-related molecules and immune cells, thereby improving its therapeutic effects on HT.

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Section: Introductionmentioning

confidence: 99%

“…Thus, blood 25OHD levels reflect vitamin D status from both diet and sunlight exposure. 7 Numerous studies have confirmed associations between HT and trace elements such as iodine and selenium; [8][9][10][11] however, the association between HT and vitamin D remains debatable.…”

Section: Introductionmentioning

confidence: 99%

Clinical Efficacy and Mechanism of Vitamin D2 in Treating Hashimoto’s Thyroiditis

Gan,

2024

JIR

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Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows

Giustina,

Bilezikian,

Adler

et al. 2024

Endocrine Reviews

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The 6th International Conference, “Controversies in Vitamin D,” was convened to discuss controversial topics, such as vitamin D metabolism, assessment, actions, and supplementation. Novel insights into vitamin D mechanisms of action suggest links with conditions that do not depend only on reduced solar exposure or diet intake and that can be detected with distinctive noncanonical vitamin D metabolites. Optimal 25-hydroxyvitamin D (25(OH)D) levels remain debated. Varying recommendations from different societies arise from evaluating different clinical or public health approaches. The lack of assay standardization also poses challenges in interpreting data from available studies, hindering rational data pooling and meta-analyses. Beyond the well-known skeletal features, interest in vitamin D's extraskeletal effects has led to clinical trials on cancer, cardiovascular risk, respiratory effects, autoimmune diseases, diabetes, and mortality. The initial negative results are likely due to enrollment of vitamin D-replete individuals. Subsequent post hoc analyses have suggested, nevertheless, potential benefits in reducing cancer incidence, autoimmune diseases, cardiovascular events, and diabetes. Oral administration of vitamin D is the preferred route. Parenteral administration is reserved for specific clinical situations. Cholecalciferol is favored due to safety and minimal monitoring requirements. Calcifediol may be used in certain conditions, while calcitriol should be limited to specific disorders in which the active metabolite is not readily produced in vivo. Further studies are needed to investigate vitamin D effects in relation to the different recommended 25(OH)D levels and the efficacy of the different supplementary formulations in achieving biochemical and clinical outcomes within the multifaced skeletal and extraskeletal potential effects of vitamin D.

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Strategies to build stronger bones in Indian children: Challenges for implementation

Mukhopadhyay,

Dutta

2024

IJMR

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Background & objectives Globally, vitamin D deficiency has been incriminated in poor bone health and growth retardation in children, impaired adult musculoskeletal health (classically described), increased risk of cardiovascular events, immune dysfunction, neurologic disorders, insulin resistance and its multiple sequelae, polycystic ovary syndrome (PCOS) and certain cancers. This review intends to holistically highlight the burden of vitamin D deficiency among children in India, the public health importance, and potential therapeutic and preventive options, utilizing the concept of implementation research. Methods A systematic search was carried out on PubMed, Embase, China National Knowledge Infrastructure (CNKI) and Cochrane database, clinicaltrials.gov, Google Scholar, and ctri.nic.in with the keywords or MeSH terms namely ‘vitamin D’, ‘cholecalciferol’, ‘ergocalciferol’, ‘children’, connected with appropriate boolean operators. Results Vitamin D deficiency/insufficiency prevalence varies from 70-90 per cent in Indian children. Rickets, stunting, impaired bone mineral health, and dental health are common problems in these children. Serum 25-hydroxy vitamin D (25(OH)D) should be maintained >20 ng/ml in children. Oral vitamin D supplementation has a high therapeutic window (1200-10,000 IU/d well tolerated). Fortification of grains, cereal, milk, bread, fruit juice, yogurt, and cheese with vitamin D has been tried in different countries across the globe. From Indian perspective, fortification of food items which is virtually used by everyone would be ideal like fortified milk or cooking oil. Fortification of “laddus” made from “Bengal gram” with vitamin D as a part of a mid-day meal programme for children can be an option. Interpretation & conclusions There is enough evidence from India to suggest the importance and utility of food fortification with vitamin D to address the epidemic of vitamin D deficiency/insufficiency in children.

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Maternal vitamin D and growth of under-five children: a systematic review and meta-analysis of observational and interventional studies

Cited by 4 publications

References 83 publications

Clinical Efficacy and Mechanism of Vitamin D2 in Treating Hashimoto’s Thyroiditis

Clinical Efficacy and Mechanism of Vitamin D2 in Treating Hashimoto’s Thyroiditis

Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows

Strategies to build stronger bones in Indian children: Challenges for implementation

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