Maternal Vertical Transmission Affecting Early-life Microbiota Development

Wang, Shaopu; Ryan, C. Anthony; Boyaval, Patrick; Dempsey, Eugene M.; Ross, R. Paul; Stanton, Catherine

doi:10.1016/j.tim.2019.07.010

Cited by 136 publications

(129 citation statements)

References 116 publications

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“…It has been reported that mothers can be responsible for the transference of (some) these microbes to the fetus, as well as their metabolites and other molecules that shape the offspring's innate immune system. 17 Two mechanisms have been proposed to explain the mother-to-infant bacterial transmission: the hematogenous bacterial route of bacteria from the gastrointestinal tract (oral cavity and gut); and the ascension of bacteria from vaginal microbiota. Both routes argued that bacteria enter into the blood circulation and are incorporated into the placenta decidua and, consequently, into the developing fetus via cord blood and amniotic fluid.…”

Section: Discussionmentioning

confidence: 99%

Extremely preterm neonates have more Lactobacillus in meconium than very preterm neonates – the in utero microbial colonization hypothesis

et al. 2020

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Growing evidence suggests that maternal microbiota can influence the neonates' gut colonization. However, the mechanisms of vertical bacterial transmission remain poorly defined. We believed that the first colonizers of the newborn come from the mother's gut and vagina during pregnancy and that this is independent of the mode of delivery. We conducted an observational longitudinal study to evaluate the link between the maternal gut microbiota and the meconium's microbiota in extremely and very preterm neonates. Bacterial DNA was extracted from samples and specific bacterial groups were quantified by RT-PCR. In this cohort of 117 preterm neonates, we detected bacterial DNA in 88% of meconium samples. Meconium microbiota of neonates born after 28 gestational weeks (very preterm neonates) showed stronger correlations with their mothers' fecal microbiota. However, neonates born before 28 gestational weeks (extremely preterm neonates) had more Lactobacillusgenus that dominated the vaginal microbiota-than very preterm neonates, regardless of the mode of delivery. Collectively, these data support the hypothesis that maternal bacteria from the gut and vagina can play a role in shaping neonates' gut microbiota and that mother-to-infant bacterial transmission is a controlled and time-specific process. ClinicalTrials.gov Identifier: NCT03663556 ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Extremely preterm neonates have more Lactobacillus in meconium than very preterm neonates – the in utero microbial colonization hypothesis

et al. 2020

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“…The establishment of Bifidobacterium spp. seeding in the neonatal gut is largely influenced by vertical transmission from mother to infant during vaginal delivery [25,26]. Birth by C-section circumvents early bifidobacterial colonization and, compared to vaginally born babies, C-section babies have decreased Bifidobacterium spp.…”

Section: Introductionmentioning

confidence: 99%

Enduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouse

et al. 2020

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“…In addition, some scholars have found that the rst colonization ora of humans originates from maternal microorganisms [20]. In our previous study, the bacteria that E. coli, Shigella and Clostridium existed in endometritis sows were also the main dominant bacteria in the intestines of a group of diarrhea piglets [21].…”

Section: Effect Of Sow Birth Canals and Gastrointestinal Ora On Endommentioning

confidence: 87%

Effect of intestinal flora on the formation of endometritis of sow

Zhang¹,

Wang²,

Dai³

et al. 2020

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Background Aberration of birth canal microbiota is one of the most important factors in the etiology of sow endomentritis. Nevertheless, reports about the structure and composition of birth canal microbiota in endomentritis sow and their relationship with intestinal microbes is limited. Therefore, understanding the relationship between birth canal microbiota and intestinal microbiota of the host has become exceedingly crucial. Results In this study, 4 healthy and 4 endomentritis sows were selected basing on whether the sow had endometritis or not in a farm of China. The microflora of their birth canal secretions and fresh feces were analyzed via sequencing the V3 + V4 region of bacterial 16S rDNA gene. The results showed that the significant difference between endometritis and healthy sows birth canal flora in the composition and abundance. Sow endomentritis was associated with increasing in the relative abundance of Porphyromonas, Clostridium_sensu_stricto_1, Streptococcus, Ezakiella, Fusobacterium, Actinobacillus, Bacteroides, and Prevotella as well as Anaerococcus. On the contrary, the majority of beneficial bacteria that belonging to Firmicutes phylum (e.g., Lactobacillus and Enterococcus ) declined in endomentritis sow. The increased relative abundance of Porphyromonas in the vaginal secretions might correlate with the decrease of Lactobacillusin the feces of endometritis sows. Moreover, the experimental result also found that some intestinal bacteria (such as Escherichia-Shigella and Bacteroides) may be bound up with the onset of sow endometritis. Conclusion Sow endometritis is closely related to the microbiota of birth canal, and that some intestinal bacteria may promote the onset of endometritis. The above results can supply a theoretical basis to research the pathogenesis of endometritis and the microbiota of sow's birth canal and gut.

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Maternal Vertical Transmission Affecting Early-life Microbiota Development

Cited by 136 publications

References 116 publications

Extremely preterm neonates have more Lactobacillus in meconium than very preterm neonates – the in utero microbial colonization hypothesis

Extremely preterm neonates have more Lactobacillus in meconium than very preterm neonates – the in utero microbial colonization hypothesis

Enduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouse

Effect of intestinal flora on the formation of endometritis of sow

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